A5081197008- Gut microbiota and health
- Diet and metabolism studies
- Dietary Effects on Health
- Alzheimer's disease research and treatments
- Analytical chemistry methods development
- Advanced Chemical Sensor Technologies
- Metabolomics and Mass Spectrometry Studies
- Effects and risks of endocrine disrupting chemicals
- Drug Transport and Resistance Mechanisms
- Neurological Disease Mechanisms and Treatments
- Analytical Chemistry and Chromatography
- Reproductive System and Pregnancy
- Pharmaceutical and Antibiotic Environmental Impacts
- Nutritional Studies and Diet
- Machine Learning in Healthcare
- Gestational Diabetes Research and Management
- Liver Disease Diagnosis and Treatment
- Vitamin D Research Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Antioxidant Activity and Oxidative Stress
- Liver Diseases and Immunity
- Transplantation: Methods and Outcomes
- Folate and B Vitamins Research
- Respiratory and Cough-Related Research
- Pesticide Residue Analysis and Safety
Instituto de Investigación Sanitaria La Fe
2018-2024
Leitat Technological Center
2018-2022
Hospital Universitari i Politècnic La Fe
2022
Universitat de València
2010-2018
ESPCI Paris
2013
ParisTech
2013
Sorbonne Université
2013
Centre National de la Recherche Scientifique
2013
Bisphenols, particularly bisphenol A (BPA), are the primary monomers used as additives in manufacturing of many consumer products. The exposure to these compounds is related endocrine-disrupting and reproductive effects, among others. For this reason, development analytical methods for their determination biological matrixes needed monitor population compounds. Their quantification at ovarian level (i.e., follicular fluid) interesting assessment content draw conclusions about infertility...
Abstract Background Bile acids have been proposed to promote colon carcinogenesis. However, there are limited prospective data on circulating bile acid levels and cancer risk in humans. Methods Associations between prediagnostic plasma of 17 primary, secondary, tertiary metabolites (conjugated unconjugated) were evaluated a nested case-control study within the European Prospective Investigation into Cancer Nutrition (EPIC) cohort. quantified by tandem mass spectrometry samples from 569...
The gut microbiota has been suggested to play a significant role in the development of overweight and obesity. However, effects calorie restriction on obese adults, especially over longer durations, are largely unexplored.Here, we longitudinally analyzed intermittent (ICR) operationalized as 5:2 diet versus continuous (CCR) fecal 147 or adults 50-week parallel-arm randomized controlled trial, HELENA Trial. primary outcome trial was differential ICR CCR gene expression subcutaneous adipose...
Multidrug-resistant organisms (MDRO) are a major threat to public health. MDRO infections, including those caused by vancomycin-resistant Enterococcus (VRE), frequently begin colonization of the intestinal tract, crucial step that is impaired microbiota. However, specific members microbiota suppress and mechanisms such protection largely unknown. Here, using metagenomics mouse models mimic patients' exposure antibiotics, we identified commensal bacteria associated with against VRE...
Alzheimer’s Disease (AD) is the most common cause of dementia, and its characteristic histopathological hallmarks are neurofibrillary tangles senile plaques. Among involved mechanisms, oxidative stress plays an important role in damaging cell components (e.g., proteins, nucleic acids). In this study, different oxidized products proteins DNA were determined urine samples from mild cognitive impairment due to AD patients (n = 53) healthy controls 27) by means ultra-performance liquid...
Abstract Bile acids (BAs) play different roles in cancer development. Some are carcinogenic and BA signaling is also involved various metabolic, inflammatory immune‐related processes. The liver the primary site of synthesis. Liver dysfunction microbiome compositional changes, such as during hepatocellular carcinoma (HCC) development, may modulate metabolism increasing concentration BAs. Observations from prospective cohorts sparse. We conducted a study (233 HCC case‐control pairs) nested...
Alzheimer Disease (AD) standard biological diagnosis is based on expensive or invasive procedures. Recent research has focused some molecular mechanisms involved since early AD stages, such as lipid peroxidation. Therefore, a non-invasive screening approach new peroxidation compounds determination would be very useful. Well-defined patients and healthy participants were recruited. Lipid determined in urine using validated analytical method liquid chromatography coupled to tandem mass...
Alzheimer disease (AD) is an increasingly common neurodegenerative disease, especially in countries with aging populations. Its diagnosis complex and usually carried out advanced stages of the disease. In addition, lipids oxidative stress have been related to AD since earliest stages. A initial or preclinical could help a more effective action treatments. Isoprostanoid biomarkers were determined plasma samples from participants (n = 12) healthy controls 31) by chromatography mass...
A rapid and sensitive analytical gas chromatography-mass spectrometry (GC-MS) method for perfume analysis to determine the phthalates banned by European Union Regulation on cosmetic samples is presented. This has been tested in commercial alcoholic determination of following seven phthalates: dibutyl phthalate, bis(2-ethylhexyl) bis(2-methoxyethyl) n-pentyl-isopentylphthalate, di-n-pentyl diisopentylphthalate benzyl butyl phthalate. Sample evaporation redissolution ethanol carried out before...
Previous studies showed a relationship between lipid oxidation biomarkers from plasma samples and Alzheimer's Disease (AD), constituting promising diagnostic tool. In this work we analyzed whether these could reflect specific brain in AD. peroxidation compounds were determined cerebrospinal fluid (CSF) AD non-AD (including other neurological pathologies) participants, by means of an analytical method based on liquid chromatography coupled with mass spectrometry. Statistical analysis...
Abstract Background and Aims Cyclooxygenase‐2 (COX‐2) is involved in different liver diseases, but little known about the significance of COX‐2 cholestatic injury. This study was designed to elucidate role expression hepatocytes during pathogenesis obstructive cholestasis. Methods We used genetically modified mice constitutively expressing human hepatocytes. Transgenic ( hCOX‐2‐Tg ) their wild‐type Wt littermates were either subjected a mid‐abdominal laparotomy or common bile duct ligation...