A5070236122- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Cancer therapeutics and mechanisms
- COVID-19 Clinical Research Studies
- Calcium signaling and nucleotide metabolism
- Phagocytosis and Immune Regulation
- Immune Response and Inflammation
- Peptidase Inhibition and Analysis
- Extracellular vesicles in disease
- Adenosine and Purinergic Signaling
- Gastroesophageal reflux and treatments
- Liver Diseases and Immunity
- Neuroinflammation and Neurodegeneration Mechanisms
- Pediatric Hepatobiliary Diseases and Treatments
- Receptor Mechanisms and Signaling
- Cancer Mechanisms and Therapy
- Pregnancy and Medication Impact
- Drug Transport and Resistance Mechanisms
Universidad Autónoma de Madrid
2023-2024
Centro de Investigación Biomédica en Red
2023-2024
Instituto de Investigaciones Biomédicas Sols-Morreale
2023-2024
Centro de Investigación en Red en Enfermedades Cardiovasculares
2023-2024
Consejo Superior de Investigaciones Científicas
2023-2024
Universitat de Barcelona
2023
In recent years, the central role of cell bioenergetics in regulating immune function and fate has been recognized, giving rise to interest immunometabolism, an area research focused on interaction between metabolic regulation function. Thus, early changes associated with polarization macrophages into pro-inflammatory or pro-resolving cells under different stimuli have characterized. Tumor-associated are among most abundant tumor microenvironment; however, it exists unmet need study effect...
Macrophages are essential components of the innate immune system that play both homeostatic roles in healthy organs, and host defence functions against pathogens after tissue injury. To accomplish their physiological role, macrophages display different profiles gene expression, function, metabolic phenotypes allow these cells to participate steps inflammatory reaction, from initiation resolution phase. In addition, significant differences exist phenotype depending on which they present...
Abstract Autophagy inducers can prevent cardiovascular aging and age-associated diseases including atherosclerosis. Therefore, we hypothesized that autophagy-inducing compounds act on atherosclerosis-relevant cells might have a protective role in the development of Here identified 3,4-dimethoxychalcone (3,4-DC) as an inducer autophagy several cell lines from endothelial, myocardial myeloid/macrophagic origin, demonstrated by aggregation autophagosome marker GFP-LC3 cytoplasm cells, well...
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main source(s): MICIN/Agencia Estatal de Investigación (DOI: 10.13039/50110001103) (NextGeneration, EU/PRTR) Background and Purpose Ferroptosis is a new regulated programmed cell death pathway, driven by iron-dependent phospholipid peroxidation, that plays an important role in the development cardiovascular diseases. The aryl hydrocarbon receptor (AhR) ligand-activated transcription factor basic...
Abstract Background and Aims Cyclooxygenase‐2 (COX‐2) is involved in different liver diseases, but little known about the significance of COX‐2 cholestatic injury. This study was designed to elucidate role expression hepatocytes during pathogenesis obstructive cholestasis. Methods We used genetically modified mice constitutively expressing human hepatocytes. Transgenic ( hCOX‐2‐Tg ) their wild‐type Wt littermates were either subjected a mid‐abdominal laparotomy or common bile duct ligation...
Abstract The cytokine storm associated with SARS‐CoV‐2 infection is one of the most distinctive pathological signatures in COVID‐19 patients. Macrophages respond to this pro‐inflammatory challenge by reprogramming their functional and metabolic phenotypes. Interestingly, human macrophages fail express inducible form NO synthase (NOS2) response activation and, therefore, not synthesized these cells. contribution exogenously added NO, via a chemical NO‐donor, on immunometabolic changes...
Abstract In recent years, the central role of cell bioenergetics in regulating immune function and fate has been recognized, giving rise to interest immunometabolism, an area research focused on interaction between metabolic regulation function. Thus, early changes associated with polarization macrophages into pro-inflammatory or pro-resolving cells under different stimuli have characterized. Tumor-associated are among most abundant tumor microenvironment; however, it exists unmet need study...