A5056768522- Autophagy in Disease and Therapy
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Endoplasmic Reticulum Stress and Disease
- CAR-T cell therapy research
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Adenosine and Purinergic Signaling
- Cancer Research and Treatments
- Immune cells in cancer
- Mitochondrial Function and Pathology
- Cancer-related Molecular Pathways
- Virus-based gene therapy research
- interferon and immune responses
- Calcium signaling and nucleotide metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Cellular transport and secretion
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- RNA regulation and disease
- Microtubule and mitosis dynamics
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
Institut Gustave Roussy
2016-2025
Université Paris-Saclay
2012-2025
Sorbonne Université
2016-2025
Centre de Recherche des Cordeliers
2016-2025
Université Paris Cité
2016-2025
Inserm
2016-2025
Institut Universitaire de France
2020-2025
La Ligue Contre le Cancer
2013-2024
Centre National de la Recherche Scientifique
2013-2022
Université Paris-Sud
2009-2021
Antineoplastic chemotherapies are particularly efficient when they elicit immunogenic cell death, thus provoking an anticancer immune response. Here we demonstrate that autophagy, which is often disabled in cancer, dispensable for chemotherapy-induced death but required its immunogenicity. In response to chemotherapy, autophagy-competent, not autophagy-deficient, cancers attracted dendritic cells and T lymphocytes into the tumor bed. Suppression of autophagy inhibited release adenosine...