A5080410227- Drug Transport and Resistance Mechanisms
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- Clinical Nutrition and Gastroenterology
- Liver Diseases and Immunity
- Amino Acid Enzymes and Metabolism
- Pediatric Hepatobiliary Diseases and Treatments
National University of Rosario
2020-2024
Metronomic chemotherapy refers to the minimum biologically effective doses of a agent given as continuous regimen without extended rest periods. Drug repurposing is defined use an already known drug for new medical indication, different from original one. In oncology combination these two therapeutic approaches called "Metronomics". The aim this work evaluate effect cyclophosphamide in metronomic schedule with repurposed losartan genetically mice models triple negative breast cancer. Our...
Abstract Background and Aims Cyclooxygenase‐2 (COX‐2) is involved in different liver diseases, but little known about the significance of COX‐2 cholestatic injury. This study was designed to elucidate role expression hepatocytes during pathogenesis obstructive cholestasis. Methods We used genetically modified mice constitutively expressing human hepatocytes. Transgenic ( hCOX‐2‐Tg ) their wild‐type Wt littermates were either subjected a mid‐abdominal laparotomy or common bile duct ligation...