A5002356390- Ion Transport and Channel Regulation
- Drug Transport and Resistance Mechanisms
- Metabolism and Genetic Disorders
- Cancer, Hypoxia, and Metabolism
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatic function and diabetes
- Cancer Cells and Metastasis
- Immune Response and Inflammation
- Angiogenesis and VEGF in Cancer
- Liver Diseases and Immunity
Institute of Physics Rosario
2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2024
National University of Rosario
2020-2023
We previously reported that, in cultured hepatocytes, mitochondrial aquaporin-8 (AQP8) channels facilitate the conversion of ammonia to urea and that expression human AQP8 (hAQP8) enhances ammonia-derived ureagenesis. In this study, we evaluated whether hepatic gene transfer hAQP8 improves detoxification normal mice as well with impaired hepatocyte metabolism. A recombinant adenoviral (Ad) vector encoding hAQP8, AdhAQP8, or a control Ad was administered via retrograde infusion into bile duct...
Metronomic chemotherapy refers to the minimum biologically effective doses of a agent given as continuous regimen without extended rest periods. Drug repurposing is defined use an already known drug for new medical indication, different from original one. In oncology combination these two therapeutic approaches called "Metronomics". The aim this work evaluate effect cyclophosphamide in metronomic schedule with repurposed losartan genetically mice models triple negative breast cancer. Our...
Abstract Background and Aims Cyclooxygenase‐2 (COX‐2) is involved in different liver diseases, but little known about the significance of COX‐2 cholestatic injury. This study was designed to elucidate role expression hepatocytes during pathogenesis obstructive cholestasis. Methods We used genetically modified mice constitutively expressing human hepatocytes. Transgenic ( hCOX‐2‐Tg ) their wild‐type Wt littermates were either subjected a mid‐abdominal laparotomy or common bile duct ligation...
To characterize, by means of univariate and multivariate approaches, the T helper (Th)-1 Th-2 responses during different phases tumor immunoediting.We used a principal component analysis applied to analyze joint behavior serum concentrations IFN-γ, IL-2, IL-10 IL-4, immunoediting, in CBi/L mice challenged with M-406 mammary adenocarcinoma.Animals equilibrium phase showed widest variations values four cytokines. In this experimental model, role IFN-γ would be related growth progression, while...