A5027046285- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- Acute Myocardial Infarction Research
- Sphingolipid Metabolism and Signaling
- Lipid metabolism and disorders
- Peroxisome Proliferator-Activated Receptors
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Drug Transport and Resistance Mechanisms
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Hormonal and reproductive studies
- Coronary Interventions and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Diet, Metabolism, and Disease
- Atrial Fibrillation Management and Outcomes
- Protease and Inhibitor Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Paraoxonase enzyme and polymorphisms
- Cardiovascular Function and Risk Factors
- Lipid metabolism and biosynthesis
University Hospital of Zurich
2015-2024
University of Zurich
2015-2024
Zentrum für Labormedizin
2015-2024
University of Liverpool
2024
University of Glasgow
2024
Wake Forest University
2023
Group Health Cooperative
2022
University Hospital of Bern
2022
Life Science Zurich
2011-2022
Swiss Integrative Center for Human Health
2012-2021
To critically evaluate the clinical implications of use non-fasting rather than fasting lipid profiles and to provide guidance for laboratory reporting abnormal or profiles.Extensive observational data, in which random have been compared with those determined under conditions, indicate that maximal mean changes at 1-6 h after habitual meals are not clinically significant [+0.3 mmol/L (26 mg/dL) triglycerides; -0.2 (8 total cholesterol; LDL +0.2 calculated remnant non-HDL cholesterol];...
This 2022 European Atherosclerosis Society lipoprotein(a) [Lp(a)] consensus statement updates evidence for the role of Lp(a) in atherosclerotic cardiovascular disease (ASCVD) and aortic valve stenosis, provides clinical guidance testing treating elevated levels, considers its inclusion global risk estimation. Epidemiologic genetic studies involving hundreds thousands individuals strongly support a causal continuous association between concentration outcomes different ethnicities; is factor...
Therapies that raise levels of HDL, which is thought to exert atheroprotective effects via on endothelium, are being examined for the treatment or prevention coronary artery disease (CAD). However, endothelial HDL highly heterogeneous, and impact patients with CAD activation eNOS eNOS-dependent pathways unknown. Here we have demonstrated that, in contrast from healthy subjects, stable an acute syndrome (HDLCAD) does not antiinflammatory stimulate repair because it fails induce NO production....
Background— High-density lipoprotein (HDL)–raising therapies are currently under intense evaluation, but the effects of HDL may be highly heterogeneous. We therefore compared endothelial from healthy subjects and patients with type 2 diabetes mellitus low (meeting criteria for metabolic syndrome), who frequently considered HDL-raising therapies. Moreover, in diabetic patients, we examined impact extended-release (ER) niacin therapy on HDL. Methods Results— was isolated (n=10) (n=33) by...
HSAN1 is an inherited neuropathy found to be associated with several missense mutations in the SPTLC1 subunit of serine palmitoyltransferase (SPT). SPT catalyzes condensation and palmitoyl-CoA, initial step de novo synthesis sphingolipids. Here we show that induce a shift substrate specificity SPT, which leads formation two atypical deoxy-sphingoid bases (DSBs) 1-deoxy-sphinganine 1-deoxymethyl-sphinganine. Both metabolites lack C1 hydroxyl group sphinganine can therefore neither converted...
Coronary plaques that are prone to rupture and cause adverse cardiac events characterized by large plaque burden, lipid content, thin fibrous caps. Statins can halt the progression of coronary atherosclerosis; however, effect proprotein convertase subtilisin kexin type 9 inhibitor alirocumab added statin therapy on burden composition remains largely unknown.To determine effects atherosclerosis using serial multimodality intracoronary imaging in patients with acute myocardial infarction.The...
Background— Endothelial dysfunction and injury are thought to play an important role in the progression of coronary artery disease (CAD). High-density lipoprotein from healthy subjects (HDL Healthy ) has been proposed exert endothelial antiapoptotic effects that may represent antiatherogenic property lipoprotein. The present study therefore aimed compare HDL CAD on activation anti- proapoptotic pathways determine which changes relevant for these processes. Methods Results— was isolated...
Apolipoprotein E (apoE) exerts potent antiinflammatory effects. Here, we investigated the effect of apoE on functional phenotype macrophages.Human receptors very-low-density lipoprotein receptor (VLDL-R) and receptor-2 (apoER2) were stably expressed in RAW264.7 mouse macrophages. In these cells, downregulated markers proinflammatory M1 (inducible nitric oxide synthase, interleukin [IL]-12, macrophage inflammatory protein-1α) but upregulated M2 (arginase I, SOCS3, IL-1 antagonist [IL-1RA])....
The European Atherosclerosis Society-European Federation of Clinical Chemistry and Laboratory Medicine Consensus Panel aims to provide recommendations optimize atherogenic lipoprotein quantification for cardiovascular risk management.We critically examined LDL cholesterol, non-HDL apolipoprotein B (apoB), particle number assays based on key criteria medical application biomarkers. (a) Analytical performance: Discordant cholesterol occurs when is measured or calculated with different assays,...
Air pollution is an important risk factor for global burden of disease. There has been recent interest in its possible role the etiology diabetes mellitus. Experimental evidence suggestive, but epidemiological limited and mixed. We therefore explored association between air prevalent diabetes, a population-based Swiss cohort. did cross-sectional analyses 6392 participants Cohort Study on Pollution Lung Heart Diseases Adults [SAPALDIA], aged 29 73 years. used estimates average individual home...
Low high-density lipoprotein cholesterol (HDL-C) characterizes an atherogenic dyslipidemia that reflects adverse lifestyle choices, impaired metabolism, and increased cardiovascular risk. HDL-C is also associated with risk of inflammatory disorders, malignancy, diabetes, other diseases. This epidemiologic evidence has not translated to raising as a viable therapeutic target, partly because does reflect (HDL) function. Mendelian randomization analyses have found no causal relationship between...
To critically evaluate the clinical implications of use non-fasting rather than fasting lipid profiles and to provide guidance for laboratory reporting abnormal or profiles.Extensive observational data, in which random have been compared with those determined under conditions, indicate that maximal mean changes at 1-6 h after habitual meals are not clinically significant [+0.3 mmol/L (26 mg/dL) triglycerides; -0.2 (8 total cholesterol; LDL +0.2 calculated remnant non-HDL cholesterol];...
Abstract The joint consensus panel of the European Atherosclerosis Society (EAS) and Federation Clinical Chemistry Laboratory Medicine (EFLM) recently addressed present future challenges in laboratory diagnostics atherogenic lipoproteins. Total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDLC), LDL (LDLC), calculated non-HDLC (=total – HDLC) constitute primary lipid for estimating risk atherosclerotic cardiovascular disease (ASCVD) can be measured nonfasting state. LDLC...