A5089537011- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Cerebrovascular and Carotid Artery Diseases
- Advanced X-ray and CT Imaging
- Atrial Fibrillation Management and Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Memory Processes and Influences
- Venous Thromboembolism Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Coronary Artery Anomalies
- Cardiac Arrest and Resuscitation
- Misinformation and Its Impacts
- Neural and Behavioral Psychology Studies
- Intelligent Tutoring Systems and Adaptive Learning
- Cardiac Health and Mental Health
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Issues in Pregnancy
- Electrolyte and hormonal disorders
- Medical History and Research
- Non-Invasive Vital Sign Monitoring
- Drug-Induced Adverse Reactions
University Hospital of Bern
2017-2025
University of Bern
2015-2025
Turku University Hospital
2023-2025
University of Turku
2023-2025
Turku PET Centre
2023-2025
Copenhagen University Hospital
2024
Rigshospitalet
2024
Medical University of Vienna
2021
University of Zurich
2020
Klinikum Mutterhaus der Borromäerinnen
2013
Coronary plaques that are prone to rupture and cause adverse cardiac events characterized by large plaque burden, lipid content, thin fibrous caps. Statins can halt the progression of coronary atherosclerosis; however, effect proprotein convertase subtilisin kexin type 9 inhibitor alirocumab added statin therapy on burden composition remains largely unknown.To determine effects atherosclerosis using serial multimodality intracoronary imaging in patients with acute myocardial infarction.The...
Aims: The Academic Research Consortium for High Bleeding Risk (ARC-HBR) defined consensus-based criteria patients at high bleeding risk (HBR) undergoing percutaneous coronary intervention (PCI). We aimed to validate the ARC-HBR outcomes using a large cohort of PCI. Methods and results: Between 2009 2016, PCI were prospectively included in Bern Registry. Patients considered be HBR if least one major criterion or two minor met. primary endpoint was (BARC) 3 5 year; ischaemic assessed...
The authors examined the hypothesis that judgments of learning (JOL), if governed by processing fluency during encoding, should be insensitive to anticipated retention interval. Indeed, neither item-by-item nor aggregate JOLs exhibited "forgetting" unless participants were asked estimate recall rates for several different intervals, in which case their estimates mimicked closely actual rates. These results and others reported suggest can access knowledge about forgetting but only when...
Background: Accurate bleeding risk stratification after percutaneous coronary intervention (PCI) is important for treatment individualization. However, there still an unmet need a more precise and standardized identification of high patients. We derived validated novel score by augmenting the PRECISE-DAPT with Academic Research Consortium High Bleeding Risk (ARC-HBR) criteria. Methods: The derivation cohort comprised 29,188 patients undergoing PCI, whom 1136 (3.9%) had (BARC) 3 or 5 at 1...
Studies investigating 10-year outcomes according to smoking status at baseline in a largescale population undergoing percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation are scarce. The authors sought assess the association between and after PCI DES implantation. We pooled individual participant data from 5 randomized trials including patients follow-up divided participants into 2 groups as per baseline. main outcome was all-cause death. Secondary included...
The identification of bleeding risk factors in patients undergoing percutaneous coronary intervention (PCI) is essential to inform subsequent management. Whether clinical presentation per se affects after PCI remains unclear.We aimed assess whether predisposes and if the Academic Research Consortium (ARC) High Bleeding Risk (HBR) criteria perform consistently acute (ACS) chronic (CCS) syndrome patients.Consecutive from Bern Registry were stratified by presentation. events at one year...
Abstract Aims To assess the prognostic utility of coronary artery calcium (CAC) scoring and computed tomography angiography (CCTA)-derived quantitative plaque metrics for predicting adverse cardiovascular outcomes. Methods results The study enrolled 2404 patients with suspected disease (CAD) but without a prior history CAD. All participants underwent CAC CCTA, quantified using an artificial intelligence (AI)-based tool (Cleerly, Inc). Percent atheroma volume (PAV) non-calcified percentage...
Abstract Aims Artificial intelligence (AI) has enabled accurate and fast plaque quantification from coronary computed tomography angiography (CCTA). However, AI detects any in up to 97% of patients. To avoid overdiagnosis, a burden safety cut-off for future events is needed. Methods Results Percent atheroma volume (PAV) was quantified with artificial intelligence-guided quantitative (AI-QCT) blinded fashion. Safety derivation performed the Turku CCTA registry, Finland, pre-defined as ≥90%...
Abstract In symptomatic patients undergoing coronary CTA for suspected artery disease (CAD), we assessed if quantification of plaque burden, in addition to luminal narrowing and clinical risk factors, offers incremental value the identification ischemic CAD on a per patient level. We evaluated 2145 who underwent with sequential selective downstream 15 O-water positron emission tomography (PET) myocardial perfusion imaging. Coronary scans were analyzed using Artificial Intelligence-guided...
Background In ST-segment-elevation myocardial infarction, angiography-based complete revascularization is superior to culprit-lesion-only percutaneous coronary intervention. Quantitative flow ratio (QFR) a novel, noninvasive, vasodilator-free method used assess the hemodynamic significance of stenoses. We aimed investigate incremental value QFR over angiography in nonculprit lesions patients with infarction undergoing angiography-guided revascularization. Methods and Results This was...
Treatment with proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on top of statins leads to plaque regression and stabilisation. The effects PCSK9 coronary physiology angiographic diameter stenosis (DS%) are unknown.
The effect of the PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor alirocumab on platelet aggregation among patients with acute myocardial infarction (AMI) remains unknown. We aimed to explore added high-intensity statin therapy P2Y12 reaction unit (PRU) AMI receiving dual antiplatelet (DAPT) a potent (ticagrelor or prasugrel). In addition, we assessed circulating platelet-derived noncoding RNAs (microRNAs and YRNAs).
Abstract Aims Routine revascularization in patients with ST-segment elevation myocardial infarction (STEMI) presenting >48 h after symptom onset is not recommended. Methods and results We compared outcomes of STEMI undergoing percutaneous coronary intervention (PCI) according to total ischaemic time. Patients included the Bern-PCI registry Multicenter Special Program University Medicine ACS (SPUM-ACS) between 2009 2019 were analysed. Based on symptom-to-balloon-time, categorized as...