A5086449617- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Glaucoma and retinal disorders
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Health and Mental Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Retinal Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Atherosclerosis and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Corneal surgery and disorders
- Cancer, Lipids, and Metabolism
- Ocular Surface and Contact Lens
- Heart Failure Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Coronary Interventions and Diagnostics
- Pharmaceutical Economics and Policy
- Thyroid Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Intraocular Surgery and Lenses
- Cardiac electrophysiology and arrhythmias
- Retinal and Optic Conditions
- Corneal Surgery and Treatments
University of Bern
2012-2025
University of Lausanne
2010-2025
University of Geneva
2016-2025
Hôpital Beau-Séjour
2017-2024
University Hospital of Geneva
2015-2024
Harvard University
2019-2024
Geneva College
2013-2024
Thrombolysis in Myocardial Infarction Study Group
2019-2024
Brigham and Women's Hospital
2019-2024
Vanderbilt University Medical Center
2024
ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation : The Task Force (ACS) European Society Cardiology (ESC).
The aim was to study the prognostic value of plasma ceramides (Cer) as cardiovascular death (CV death) markers in three independent coronary artery disease (CAD) cohorts.Corogene is a prospective Finnish cohort including stable CAD patients (n = 160). Multiple lipid biomarkers and C-reactive protein were measured addition Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:0), Cer(d18:1/24:1). Subsequently, association between high-risk CV mortality investigated Special Program University...
Background— American College of Cardiology/American Heart Association guidelines for the diagnosis and management heart failure recommend investigating exacerbating conditions such as thyroid dysfunction, but without specifying impact different thyroid-stimulation hormone (TSH) levels. Limited prospective data exist on association between subclinical dysfunction events. Methods Results— We performed a pooled analysis individual participant using all available cohorts with function tests...
Working Group on ThrombosisOświadczenie: Wytyczne ESC reprezentują stanowisko tego towarzystwa i powstały po dokładnym uwzględnieniu wiedzy naukowej medycznej oraz dowodów dostępnych w
Systemic levels of trimethylamine N-oxide (TMAO), a pro-atherogenic and pro-thrombotic metabolite produced from gut microbiota metabolism dietary (TMA)-containing nutrients such as choline or carnitine, predict incident cardiovascular event risks in stable primary secondary prevention subjects. However, the prognostic value TMAO setting acute coronary syndromes (ACS) remains unknown.We investigated relationship with among sequential patients presenting ACS two independent cohorts. In...
Lipoprotein(a) is a presumed risk factor for atherosclerotic cardiovascular disease. Olpasiran small interfering RNA that reduces lipoprotein(a) synthesis in the liver.
Direct oral anticoagulants (DOACs) are preferred over warfarin for stroke prevention in atrial fibrillation. Meta-analyses using individual patient data offer substantial advantages study-level data.We used from the COMBINE AF (A Collaboration Between Multiple Institutions to Better Investigate Non-Vitamin K Antagonist Oral Anticoagulant Use Atrial Fibrillation) database, which includes all patients randomized 4 pivotal trials of DOACs versus fibrillation (RE-LY [Randomized Evaluation...
Atherosclerotic cardiovascular disease (ASCVD) underlies the thrombotic events intimately associated with myocardial infarction, a significant proportion of ischaemic strokes, as well critical limb ischaemia. Such confer substantial mortality, physical and/or mental disability, and cost for individual society.1 Indeed, no finite value can be attributed to individual, although survival subsequent quality life are factors, especially in young individuals ASCVD.2 Although advent precision...
We aimed to assess the prevalence and management of clinical familial hypercholesterolaemia (FH) among patients with acute coronary syndrome (ACS). studied 4778 ACS from a multi-centre cohort study in Switzerland. Based on personal history premature cardiovascular disease LDL-cholesterol levels, two validated algorithms for diagnosis FH were used: Dutch Lipid Clinic Network algorithm possible (score 3–5 points) or probable/definite (>5 points), Simon Broome Register FH. At time...
Proprotein convertase subtilisin kexin 9 (PCSK9) is an emerging target for the treatment of hypercholesterolaemia, but clinical utility PCSK9 levels to guide unknown. We aimed prospectively assess prognostic value plasma in patients with acute coronary syndromes (ACS). Plasma were measured 2030 ACS undergoing angiography a Swiss prospective cohort. At 1 year, association between tertiles and all-cause death was assessed adjusting Global Registry Acute Coronary Events (GRACE) variables, as...
Background: Chest pain can be caused by various conditions, with life-threatening cardiac disease being of greatest concern. Prediction scores to rule out coronary artery have been developed for use in emergency settings. We and validated a simple prediction primary care. Methods: conducted cross-sectional diagnostic study 74 care practices Germany. Primary physicians recruited all consecutive patients who presented chest ( n = 1249) recorded symptoms findings each patient (derivation...
Patients with heterozygous familial hypercholesterolemia (FH) and coronary heart disease have high mortality rates. However, in an era of high-dose statin prescription after acute syndrome (ACS), the risk recurrent cardiovascular events associated FH might be mitigated. We compared event rates between patients without ACS.We studied 4534 ACS enrolled a multicenter, prospective cohort study Switzerland 2009 2013 who were individually screened for on basis clinical criteria according to 3...
<h3>Importance</h3> Atrial fibrillation (AF) is the most common heart rhythm disturbance, continues to increase in incidence, and results significant morbidity mortality. The marine omega-3 fatty acids, eicosapentaenoic acid (EPA) docosahexaenoic (DHA), vitamin D have been reported both benefits risks with respect incident AF, but large-scale, long-term randomized trial data are lacking. <h3>Objective</h3> To test effects of administration acids on AF. <h3>Design, Setting, Participants</h3>...