A5017529464- Mechanical Circulatory Support Devices
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Acute Ischemic Stroke Management
- Cardiac pacing and defibrillation studies
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrhythmias and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Sepsis Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Venous Thromboembolism Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Stress Responses and Cortisol
- Diabetes Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Transplantation: Methods and Outcomes
- Potassium and Related Disorders
- Medication Adherence and Compliance
- Metabolism and Genetic Disorders
- Circadian rhythm and melatonin
- Blood Pressure and Hypertension Studies
Medical University of South Carolina
2022-2025
Clinical Research Institute
2019-2024
Duke Medical Center
2021-2024
Duke University
2019-2024
Brigham and Women's Hospital
2016-2024
Harvard University
2017-2024
Thrombolysis in Myocardial Infarction Study Group
2017-2024
International Society for Heart and Lung Transplantation
2024
IFC Research (United Kingdom)
2024
Yale University
2024
Direct oral anticoagulants (DOACs) are preferred over warfarin for stroke prevention in atrial fibrillation. Meta-analyses using individual patient data offer substantial advantages study-level data.We used from the COMBINE AF (A Collaboration Between Multiple Institutions to Better Investigate Non-Vitamin K Antagonist Oral Anticoagulant Use Atrial Fibrillation) database, which includes all patients randomized 4 pivotal trials of DOACs versus fibrillation (RE-LY [Randomized Evaluation...
ABSTRACT The accessibility of individual participant‐level data (IPD) enhances the evaluation moderation effects patient covariates. It facilitates provision accurate estimation intervention and confidence intervals by incorporating covariate correlations across multiple clinical trials. With a time‐to‐event outcome, Cox regression can be applied for network meta‐analysis (NMA) using IPD. However, there lacks comprehensive reviews comparisons specifications assumptions these models their...
The use of non-vitamin K antagonist oral anticoagulants (NOACs) instead vitamin antagonists (VKAs) in patients with atrial fibrillation (AF) and coexisting valvular heart disease (VHD) is substantial interest. This study explored outcomes AF without VHD the ENGAGE AF–TIMI 48 (Effective Anticoagulation factor Xa Next Generation Atrial Fibrillation-Thrombolysis In Myocardial Infarction 48) trial, comparing edoxaban warfarin. Valvular was defined as history or baseline echocardiography evidence...
<h3>Importance</h3> The new United Network for Organ Sharing (UNOS) donor heart allocation system gives priority to patients supported with nondischargeable mechanical circulatory support (MCS) devices while awaiting transplant. Whether there has been a change in temporary MCS use cardiac intensive care units (CICUs) since the implementation of this policy is unknown. <h3>Objectives</h3> To examine whether UNOS revision October 2018 was associated changes CICUs and differed between US...
Background The optimal anticoagulation strategy for patients with atrial fibrillation (AF) and bioprosthetic valve (BPV) replacement or native repair remains uncertain. Hypothesis We evaluated the safety efficacy of apixaban vs warfarin in AF a history BPV repair. Methods Using data from Apixaban Reduction Stroke Other Thromboembolic Events Atrial Fibrillation (ARISTOTLE) (n = 18 201), randomized trial comparing AF, we analyzed subgroup 251) prior surgery. contacted sites by telephone to...
Temporary mechanical circulatory support (MCS) devices provide hemodynamic assistance for shock refractory to pharmacological treatment. Most registries have focused on single or specific etiologies of shock, limiting data regarding overall practice patterns with temporary MCS in cardiac intensive care units.The CCCTN (Critical Care Cardiology Trials Network) is a multicenter network tertiary CICUs North America. Between September 2017 and 2018, each center (n=16) contributed 2-month...
Cardiogenic shock presents with variable severity. Categorizing cardiogenic into clinical stages may improve risk stratification and patient selection for therapies. We sought to determine whether a structured implementation of the 2019 Society Cardiovascular Angiography Interventions staging criteria that is ascertainable in registries discriminates mortality contemporary population or at-risk shock.We developed pragmatic application criteria-A (at-risk), B (beginning), C (classic shock), D...
The prognosis of patients with atrial fibrillation (AF) and ischemic stroke while taking oral anticoagulation is poorly understood. This study aimed to characterize the outcomes following a event on anticoagulation.
The efficacy and safety of non-vitamin-K antagonist oral anticoagulants (NOACs) across the spectrum body mass index (BMI) weight (BW) remain uncertain.
Background Evidence‐based therapies are generally underused for cardiovascular risk reduction; however, less is known about contemporary patients with type 2 diabetes mellitus and atherosclerotic disease. Methods Results Pharmacy medical claims data from within Anthem were queried established disease mellitus. Using an index date of April 18, 2018, we evaluated the proportion a prescription claim any 3 evidence‐based on, or covering, ±30 days: high‐intensity statin, angiotensin‐converting...
Abstract While novel oral anticoagulants are increasingly used to reduce risk of stroke in patients with atrial fibrillation, vitamin K antagonists such as warfarin continue be extensively for prevention across the world. effective reducing strokes, complex pharmacodynamics make it difficult use clinically, many experiencing under- and/or over- anticoagulation. In this study we employed a implementation deep reinforcement learning provide clinical decision support optimize time therapeutic...
Cardiogenic shock (CS) can be complicated by severe valvular heart disease (VHD). We analyzed cardiac intensive care unit (CICU) admissions VHD status. The Critical Care Cardiology Trials Network is a multicenter network of tertiary CICUs. Centers contributed data from consecutive during 2-month annual snapshots 2017 to 2023. CS were classified as having attributed VHD, with non-causative or without VHD. Demographics and therapies compared. Unadjusted adjusted odds ratios for in-hospital...
Background Several studies have shown improved outcomes in closed compared with open medical and surgical intensive care units. However, very little is known about the ideal organizational structure modern cardiac unit (CICU). Methods Results We retrospectively reviewed consecutive unique admissions (n=3996) to our tertiary CICU from September 2013 October 2017. The aim of study was assess for differences clinical between an a CICU. used multivariable logistic regression adjusting...