A5056206844- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- GDF15 and Related Biomarkers
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- S100 Proteins and Annexins
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Acute Ischemic Stroke Management
- Viral gastroenteritis research and epidemiology
- Cardiac Arrest and Resuscitation
- Cardiovascular Health and Disease Prevention
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Effects of Exercise
- Chronic Kidney Disease and Diabetes
- Cardiac Health and Mental Health
- Cardiac, Anesthesia and Surgical Outcomes
Uppsala University
2016-2025
University of Helsinki
2024
Uppsala University Hospital
2003-2023
University Medical Center
2016
Boston University
2016
Population Health Research Institute
2016
Clinical Research Institute
2016
Boston Medical Center
2016
Mora lasarett
2014
Örebro University Hospital
2004-2009
Recent reports have indicated that there may be an increased risk of late stent thrombosis with the use drug-eluting stents, as compared bare-metal stents.We evaluated 6033 patients treated stents and 13,738 in 2003 2004, using data from Swedish Coronary Angiography Angioplasty Registry. The outcome analysis covering a period up to 3 years was based on 1424 deaths 2463 myocardial infarctions adjusted for differences baseline characteristics.The two study groups did not differ significantly...
Atrial fibrillation (AF) is associated with an increased risk of stroke, which currently estimated by clinical characteristics. The cardiac biomarkers N-terminal fragment B-type natriuretic peptide (NT-proBNP) and troponin high-sensitivity (cTn-hs) are independently stroke in AF. Our objective was to develop validate a new biomarker-based score improve prognostication patients AF.A developed internally validated 14 701 AF levels determined at baseline, median follow-up 1.9 years. Biomarkers...
<h3>Objective:</h3> The aim of the study was to compare time-trends in mortality rates and treatment patterns between patients with without diabetes based on Swedish register coronary care (Register Information Knowledge about Heart Intensive Care Admission [RIKS-HIA]). <h3>Methods:</h3> Post myocardial infarction rate is high diabetic patients, who seem receive less evidence-based treatment. Mortality 1995–1998 1999–2002 were studied 70 882 (age <80 years), 14 873 whom had (the first...
Whether the superior results of percutaneous coronary intervention (PCI) reported in clinical trials which patients with ST-segment elevation myocardial infarction (STEMI) received reperfusion treatment can be replicated daily practice has been questioned, especially whether it is to prehospital thrombolysis (PHT).To evaluate outcome different strategies consecutive STEMI patients.A prospective observational cohort study 26 205 Register Information and Knowledge about Swedish Heart Intensive...
It is unknown whether patients with non-ST-elevation myocardial infarction derive a similar benefit from an early invasive therapy at different levels of renal function.A total 23 262 consecutive <or=80 years old were included in nationwide coronary care unit register between 2003 and 2006. Glomerular filtration rate (eGFR) was estimated the Modification Diet Renal Disease Study formula. Patients divided into medically or invasively treated groups if revascularized within 14 days admission....
The long-term safety and efficacy of drug-eluting coronary stents have been questioned.We evaluated 47,967 patients in Sweden who received a stent were entered into the Swedish Coronary Angiography Angioplasty Registry between 2003 2006 for whom complete follow-up data available 1 to 5 years (mean, 2.7). In primary analysis, we compared one (10,294 patients) with those bare-metal (18,659), after adjustment differences clinical characteristics vessels lesions.Analyses outcome based on 2380...
To examine clinical characteristics, presenting symptoms, use of therapy and in-hospital complications in relation to renal function patients with myocardial infarction (MI).Observational study.Nationwide coronary care unit registry between 2003-2006 Sweden.Consecutive MI available creatinine (n = 57,477).Glomerular filtration rate was estimated the Modification Diet Renal Disease Study formula. With declining were older, had more co-morbidities often used cardio-protective medication on...
Aims There are sparse data on the impact of pre-hospital thrombolysis (PHT) in real-life patients. We therefore evaluated treatment delays and outcome a large cohort ambulance-transported patients with ST-elevation myocardial infarction (STEMI) according to PHT delivered by paramedics or in-hospital thrombolysis. Methods results Prospective study used from Swedish Register Cardiac intensive care admitted coronary units 75 hospitals 2001–2004. Ambulance-transported thrombolytic-treated...
The global COVID-19 pandemic is caused by the SARS-CoV-2 virus entering human cells using angiotensin-converting enzyme 2 (ACE2) as a cell surface receptor. ACE2 shed to circulation, and higher plasma level of soluble (sACE2) might reflect cellular expression ACE2. present study explored associations between sACE2 clinical factors, cardiovascular biomarkers, genetic variability.
In atrial fibrillation (AF), mortality remains high despite effective anticoagulation. A model predicting the risk of death in these patients is currently not available. We developed and validated a score for anticoagulated with AF including both clinical information biomarkers. The new was internally 14 611 randomized to apixaban vs. warfarin median 1.9 years. External validation performed 8548 dabigatran 2.0 Biomarker samples were obtained at study entry. Variables significantly...
Atrial fibrillation is associated with increased but variable risk of stroke. Our aim was to validate the recently developed biomarker-based ABC (age, biomarkers [high-sensitivity troponin and N-terminal fragment B-type natriuretic peptide], clinical history prior stroke/transient ischemic attack)-stroke score compare its performance CHA2DS2VASc ATRIA (Anticoagulation Risk Factors in Fibrillation) scores.The ABC-stroke includes age, (N-terminal peptide high-sensitivity cardiac troponin),...
<h3>Importance</h3> Inflammation promotes cardiovascular disease and anti-inflammatory treatment reduces events in patients with chronic coronary syndrome. Chronic kidney (CKD) is a risk factor for disease. It unclear how inflammation mediated by interleukin 6 (IL-6) CKD linked to <h3>Objective</h3> To investigate associations between IL-6 outcomes syndrome association function. <h3>Design, Setting, Participants</h3> This multicenter cohort study included enrolled at 663 centers 39 countries...
A widespread outbreak of tularemia in Sweden 2000 was investigated a case-control study which 270 reported cases were compared with 438 controls. The affected parts where had hitherto been rare, and these "emergent" areas the disease-endemic areas. Multivariate regression analysis showed mosquito bites to be main risk factor, an odds ratio (OR) 8.8. Other factors owning cat (OR 2.5) farm work 3.2). Farming factor only area. Swollen lymph nodes wound infections more common emergent area,...
The objective was to evaluate the role of risk factors and stent type for thrombosis (ST) using a large real world registry.We evaluated all consecutive coronary implantations in Sweden from May 1, 2005, June 30, 2007. All cases ST, documented Swedish angiography angioplasty registry until September 21, 2008, were analyzed. ST registered 882 73 798 stents. Acute syndromes, insulin-treated diabetes mellitus, smoking, previous intervention, warfarin treatment, small diameter, stenting...
Background Dyslipidemia is a major risk factor for cardiovascular events. The prognostic importance of lipoproteins in patients with atrial fibrillation not well understood. We aimed to explore the association between apolipoprotein A1 (ApoA1) and B (ApoB) events receiving oral anticoagulation. Methods Results Using data from ARISTOTLE (Apixaban Reduction Stroke Other Thromboembolic Events Atrial Fibrillation) trial, ApoA1 ApoB plasma levels were measured at baseline 14 884 patients. Median...
Abstract Aims Biomarkers specifically related to atrial tissue may increase the understanding of pathophysiology fibrillation (AF) and further improve risk prediction in this setting. Bone morphogenetic protein 10 (BMP10) is a expressed myocardium. We evaluated association between BMP10 ischaemic stroke other cardiovascular events large cohorts patients with AF, treated without oral anticoagulation (OAC). Methods results was measured plasma samples collected at randomisation AF OAC ACTIVE A...
Based on clinical and laboratory surveillance data, trends in the incidence rates of genital Chlamydia trachomatis infections Sweden between 1991 1999 were analysed according to age group sex. The influence changes methods reported was assessed. After a decrease rate infection 36% 1994, followed by period stability, 20% increase observed 1997 (from 157 189/100,000). Between female:male ratio decreased from 1.7 1.4. Incidence started 1994 15-19 y for both sexes. Crude positivity increased...