Shashank S. Sinha
A5022878011- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Sepsis Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Cardiac pacing and defibrillation studies
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Innovations in Medical Education
- Health and Medical Research Impacts
- Health Systems, Economic Evaluations, Quality of Life
- Transplantation: Methods and Outcomes
- Congenital Heart Disease Studies
- COVID-19 Clinical Research Studies
- Medication Adherence and Compliance
- Primary Care and Health Outcomes
- Ultrasound in Clinical Applications
- Healthcare Policy and Management
- Cardiac Imaging and Diagnostics
- Respiratory Support and Mechanisms
- Trauma and Emergency Care Studies
- COVID-19 and healthcare impacts
- Intensive Care Unit Cognitive Disorders
Inova Fairfax Hospital
2019-2025
Alaska Heart and Vascular Institute
2019-2024
Women & Infants Hospital of Rhode Island
2024
Brown University
2024
Manipal Academy of Higher Education
2024
Tufts Medical Center
2021-2024
Inova Health System
2022-2024
Galgotias University
2024
Tufts University
2024
New York University
2023
Background: Risk stratifying patients with cardiogenic shock (CS) is a major unmet need. The recently proposed Society for Cardiovascular Angiography and Interventions (SCAI) stages as an approach to identify at risk in-hospital mortality remains under investigation. We studied the utility of SCAI further explored impact hemodynamic congestion on clinical outcomes. Methods: CS Working Group registry includes from 8 medical centers enrolled between 2016 2019. Patients were classified by...
Background Cardiogenic shock (CS) is a heterogeneous syndrome with varied presentations and outcomes. We used machine learning approach to test the hypothesis that patients CS have distinct phenotypes at presentation, which are associated unique clinical profiles in‐hospital mortality. Methods Results analyzed data from 1959 2 international cohorts: CSWG (Cardiogenic Shock Working Group Registry) (myocardial infarction [CSWG‐MI; n=410] acute‐on‐chronic heart failure [CSWG‐HF; n=480]) DRR...
Cardiogenic shock continues to carry a high mortality rate despite contemporary care, with no breakthrough therapies shown improve survival over the past few decades. It is time-sensitive condition that commonly results in cardiovascular complications and multisystem organ failure, necessitating multidisciplinary expertise. Managing patients cardiogenic remains challenging even well-resourced settings, an important subgroup of may require cardiac replacement therapy. As result, idea...
This study uses the Medicare Provider Analysis and Review file to examine whether coded severity of illness is associated with reduced rates readmission after implementation Hospital Readmissions Reduction Program.
<h3>Importance</h3> The new United Network for Organ Sharing (UNOS) donor heart allocation system gives priority to patients supported with nondischargeable mechanical circulatory support (MCS) devices while awaiting transplant. Whether there has been a change in temporary MCS use cardiac intensive care units (CICUs) since the implementation of this policy is unknown. <h3>Objectives</h3> To examine whether UNOS revision October 2018 was associated changes CICUs and differed between US...
Early reports suggest the number of cardiac intensive care unit (CICU) patients with primary noncardiac diagnoses is rising in United States, but no national data currently exist. We examined changes among elderly admitted to a CICU during past decade.Using 2003 2013 Medicare data, we grouped CICUs into 2 categories based on principal diagnosis at discharge: (1) and (2) diagnoses. patient demographics, comorbidities, procedure use, risk-adjusted in-hospital mortality. Among 3.4 million...
Temporary mechanical circulatory support (MCS) devices provide hemodynamic assistance for shock refractory to pharmacological treatment. Most registries have focused on single or specific etiologies of shock, limiting data regarding overall practice patterns with temporary MCS in cardiac intensive care units.The CCCTN (Critical Care Cardiology Trials Network) is a multicenter network tertiary CICUs North America. Between September 2017 and 2018, each center (n=16) contributed 2-month...
Cardiogenic shock occurring in the setting of advanced heart failure (HF-CS) is increasingly common. However, recent studies have focused almost exclusively on acute myocardial infarction-related CS. We sought to define clinical, hemodynamic, metabolic, and treatment parameters associated with clinical outcomes among patients HF-CS, using data from Shock Working Group registry.Patients HF-CS were identified multicenter registry divided into 3 outcome categories assessed at hospital...
The efficacy and safety of prophylactic full-dose anticoagulation antiplatelet therapy in critically ill COVID-19 patients remain uncertain.COVID-PACT (Prevention Arteriovenous Thrombotic Events Critically-ill Patients Trial) was a multicenter, 2×2 factorial, open-label, randomized-controlled trial with blinded end point adjudication intensive care unit-level COVID-19. were randomly assigned to strategy or standard-dose anticoagulation. Absent an indication for therapy, additionally either...
Cardiogenic shock presents with variable severity. Categorizing cardiogenic into clinical stages may improve risk stratification and patient selection for therapies. We sought to determine whether a structured implementation of the 2019 Society Cardiovascular Angiography Interventions staging criteria that is ascertainable in registries discriminates mortality contemporary population or at-risk shock.We developed pragmatic application criteria-A (at-risk), B (beginning), C (classic shock), D...
Background: Little is known about clinical characteristics, hospital course, and longitudinal outcomes of patients with cardiogenic shock (CS) related to heart failure (HF-CS) compared acute myocardial infarction (AMI; CS AMI [AMI-CS]). Methods: We examined in-hospital 1-year 520 (219 AMI-CS, 301 HF-CS) consecutive (January 3, 2017–December 31, 2019) in a single-center registry. Results: Mean age was 61.5±13.5 years, 71% were male, 22% Black patients, 63% had chronic kidney disease. The...