A5036199110- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Cardiac Ischemia and Reperfusion
- Cardiac electrophysiology and arrhythmias
- Sepsis Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Cancer Treatment and Pharmacology
- Respiratory Support and Mechanisms
- Migraine and Headache Studies
- Acute Kidney Injury Research
- Cardiovascular Effects of Exercise
- ECG Monitoring and Analysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Hallucinations in medical conditions
- Botulinum Toxin and Related Neurological Disorders
- Congenital Heart Disease Studies
- Neurological Complications and Syndromes
- Clinical Reasoning and Diagnostic Skills
- Ophthalmology and Eye Disorders
- Diet and metabolism studies
- Electroconvulsive Therapy Studies
- Cardiac Health and Mental Health
Odense University Hospital
2017-2025
Aarhus University Hospital
2014-2025
Aarhus University
2015-2025
Aalborg University Hospital
2024-2025
Lillebaelt Hospital
2023
Vejle Sygehus
2023
University of Southern Denmark
2018-2021
Regional Hospital Randers
2020
Rigshospitalet
2017
Background Cardiogenic shock (CS) is a heterogeneous syndrome with varied presentations and outcomes. We used machine learning approach to test the hypothesis that patients CS have distinct phenotypes at presentation, which are associated unique clinical profiles in‐hospital mortality. Methods Results analyzed data from 1959 2 international cohorts: CSWG (Cardiogenic Shock Working Group Registry) (myocardial infarction [CSWG‐MI; n=410] acute‐on‐chronic heart failure [CSWG‐HF; n=480]) DRR...
Cardiogenic shock (CS) is associated with high mortality and medical therapies have failed to improve survival. Treatment lactate improved cardiac function which may benefit this condition. Comprehensive hemodynamic assessment of administration in CS lacking, the mechanisms underlying cardiovascular effects not yet been elucidated. In study we aimed cardiometabolic treatment experimental ischemic CS. a randomized, blinded design, 20 female pigs (60 kg) were studied. Left main coronary artery...
Objectives To describe the contemporary trends in use of mechanical circulatory support (MCS) patients with acute myocardial infarction and cardiogenic shock (AMICS). evaluate survival benefit early application intra-aortic balloon pump (IABP) or Impella CP. Methods A cohort study all consecutive AMICS undergoing percutaneous coronary intervention (PCI) <24 hours symptom onset (early PCI) southeastern Denmark from 2010 to 2017. matched case–control comparing 30-day mortality between...
Abstract Background Acute myocardial infarction complicated by cardiogenic shock (AMICS) is frequently preceded out-of-hospital cardiac arrest (OHCA), with risk of anoxic brain injury. Neuron-specific enolase (NSE) central to neuroprognostication; however, concomitant hemolysis can increase NSE independent neuronal injury due the presence in erythrocytes. This consideration critical AMICS patients treated a microaxial flow pump (Impella, Abiomed), where frequent. Methods and results We...
Background: The incidence of cardiogenic shock (CS) in patients with ST-segment elevation myocardial infarction (STEMI) is as high 10%. majority are thought to develop CS after admission (late CS), but the a contemporary STEMI cohort admitted for primary percutaneous intervention remains unknown. Aim: aim this study was assess and time onset suspected two high-volume tertiary heart centres variables associated development late CS. Methods: We included consecutive acute coronary angiography...
Short-term mechanical circulatory support is increasingly used in the management of cardiogenic shock, but data from controlled studies are sparse. Thus, real-life on complication rates and predictors adverse outcome important.The objective this study was to analyse experience with Impella devices profound shock.A retrospective 109 consecutive patients severe shock after myocardial infarction, acute heart failure, or cardiac surgery. Possible device-related complications were registered...
Cardiogenic shock (CS) is known to induce an inflammatory response. The prognostic utility of this remains unclear. To investigate the association between C-reactive protein (CRP) levels and leucocyte count mortality in patients with acute myocardial infarction complicated by CS (AMICS).Consecutive (N = 1716) admitted 2010 2017 individually validated diagnosis AMICS were included. analysis was restricted alive at 48 h after first medical contact a valid CRP measurement ± 12 from contact. A...
The diagnosis of cardiogenic shock depends on clinical signs poor perfusion and low blood pressure. Lactate concentration will increase with tissue perfusion, it has prognostic value in patients. We sought to assess the lactate subjects admitted suspected ST-elevation myocardial infarction (STEMI).In 2,094 (93%) out 2,247 consecutive STEMI-subjects, was measured admission. 30-day mortality assessed addition peripheral hypoperfusion, systolic pressure (sBP), left ventricular ejection fraction...
The aim of this study was to evaluate the Impella CP over veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and their impact on left ventricular unloading end-organ perfusion.Cardiogenic shock (CS) induced by injecting microspheres into coronary artery in fourteen adult female swine. or VA-ECMO initiated presence CS evaluated after 60 minutes. Left pressure-volume area (PVA, total mechanical work) obtained from a conductance catheter. Results are presented as mean (95% confidence...
Abstract Background Concomitant vasoactive drugs are often required to maintain adequate perfusion pressure in patients with acute myocardial infarction (AMI) and cardiogenic shock (CS) receiving hemodynamic support an axial flow pump (Impella CP). Objective To compare the effect of equipotent dosages epinephrine, dopamine, norepinephrine, phenylephrine on cardiac work end-organ a porcine model profound ischemic CS supported Impella CP. Methods was induced 10 pigs by stepwise intracoronary...
Background Cardiogenic shock (CS) presents a medical challenge with limited treatment options. Positive end-expiratory pressure (PEEP) during mechanical ventilation has been linked clinical benefits in patients CS. This study investigated whether increasing PEEP levels could unload the left ventricle (LV) CS large animal model of LV-CS. Methods Left cardiogenic was induced 26 female pigs (60 kg) by microsphere injections into main coronary artery. In one study, protocol increased (5, 10, and...
The Thrombolysis in Myocardial Infarction (TIMI) risk score estimates mortality for patients with ST-elevation myocardial infarction (STEMI). This study aimed to investigate whether biomarkers reflecting the neurohormonal response (pro-atrial natriuretic peptide (proANP), mid-regional pro-adrenomedullin (MR-proADM), and copeptin), inflammation (suppression of tumorigenicity 2 (ST2), C-reactive protein (CRP), leukocytes), troponin add prognostic value TIMI score. sub-study prospective PREDICT...
INTRODUCTION. Large language models have recently gained interest within the medical community. Their clinical impact is currently being investigated, with potential application in pharmaceutical counselling, which has yet to be assessed. METHODS. We performed a retrospective investigation of ChatGPT 3.5 and 4.0 response 49 consecutive inquiries encountered joint counselling service Central North Denmark regions. Answers were rated by comparing them answers generated physicians. RESULTS....
Most studies in acute myocardial infarction complicated by cardiogenic shock (AMICS) include patients presenting with and without out-of-hospital cardiac arrest (OHCA). The aim was to compare OHCA non-OHCA AMICS terms of hemodynamics, management the intensive care unit (ICU) outcome.From a cohort corresponding two thirds Danish population, all admitted from 2010-2017 were individually identified through patient records.A total 1716 which 723 (42%) presented OHCA. A 1532 survived ICU...
Mortality in patients with acute myocardial infarction-related cardiogenic shock (AMICS) is high, but a widely accepted tool for individual risk assessment lacking. A reliable prediction model could assist clinical decision making, patient selection trials, and comparison of AMICS populations. Therefore, the aim this study was to develop externally validate 30-day mortality patients. This retrospective cohort included from 2017 2021(development cohort) 2010-2017 (validation cohort). Patients...
The recent DanGer shock trial found reduced mortality, but increased risk of acute kidney injury (AKI) in patients treated with a microaxial flow pump after an myocardial infarct cardiogenic shock. AKI has previously been associated short-term whereas data on long-term outcomes are sparse. We aimed to describe the frequency and factors as well mortality morbidity. A retrospective observational study comprising admitted infarction Denmark between 2010-2017 function from RETROSHOCK cohort....
Cardiogenic shock (CS) is characterized by reduced cardiac output (CO), end-organ perfusion, and high mortality. Medical therapies have failed to improve survival. The ketone body 3-hydroxybutyrate (3-OHB) enhances function in heart failure CS. We aimed elucidate the cardiovascular cardiometabolic effects of 3-OHB treatment during In a randomized, assessor-blinded crossover design, we studied 16 female pigs (60 kg, 5 months age). CS was induced left main coronary artery microsphere...
Abstract Background Liver injury is a frequent complication in patients with acute myocardial infarction complicated by cardiogenic shock (AMICS). The Model for End-Stage Disease incorporating albumin (MELD-albumin) quantifies liver injury. This study assesses the association between MELD-albumin score and all-cause mortality among AMICS. Methods Results From retrospective cohort of 1716 consecutive AMICS admitted 2010 2017, we included who survived until day 3 had complete laboratory data...
Background Cardiogenic shock is the leading cause of death in patients with acute myocardial infarction, short-term mortality approximately 50%. Whether diabetes mellitus and high blood glucose levels are associated contemporary infarction complicated by cardiogenic inadequately described. Purpose To investigate if admission were 30-day a large, population shock. Methods Patients admitted at two tertiary centres Denmark from 2010 to 2017 individually identified through patient charts,...
Acute myocardial infarction complicated by cardiogenic shock (AMICS) comprises a heterogeneous population with high mortality. Insight in timing and cause of death may improve understanding the condition aid individualization treatment. This was assessed retrospective, multicenter observational cohort study based on 1,716 patients AMICS treated during period 2010 to 2017, whom 904 died before hospital discharge. Patients were identified through national registries review individual charts....
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) with profound left ventricular (LV) failure is associated inadequate LV emptying. To unload the LV, VA-ECMO can be combined Impella CP (ECMELLA). We hypothesized that ECMELLA improves cardiac energetics compared in a porcine model of cardiogenic shock (CS).
Background: Cardiogenic shock complicating ST-elevation myocardial infarction is characterised by progressive left ventricular dysfunction causing inflammation and neurohormonal activation. Often, cardiogenic develops after hospital admission. Whether a activation precede development of clinical unknown. Methods results: In 93% 2247 consecutive patients with suspected admitted at two tertiary heart centres, admission plasma levels pro-atrial natriuretic peptide, copeptin, mid-regional...
Neutrophil gelatinase-associated lipocalin (NGAL) is an inflammatory biomarker related to acute kidney injury (AKI). Including 1892 consecutive patients with ST-elevation myocardial infarction (STEMI), in which NGAL was measured 1624 (86%) on admission and a subgroup at 6-12 h (n = 163) 12-24 222) after admission, this study aimed evaluate the prognostic value of predicting AKI mortality. Patients were stratified based whether their plasma concentration greater than or equal to/less median....