A5062766421- Acute Ischemic Stroke Management
- Barrier Structure and Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac electrophysiology and arrhythmias
- Neurological Disease Mechanisms and Treatments
- Cardiac Arrest and Resuscitation
- Migraine and Headache Studies
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Thermoregulation and physiological responses
- Extracellular vesicles in disease
- Diet and metabolism studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Ion channel regulation and function
- Photoacoustic and Ultrasonic Imaging
- Laser Applications in Dentistry and Medicine
- Nitric Oxide and Endothelin Effects
- Mechanical Circulatory Support Devices
- Diet, Metabolism, and Disease
Aarhus University
2021-2025
Aarhus University Hospital
2024-2025
Regionshospitalet Viborg
2024
Cardiogenic shock (CS) is associated with high mortality and medical therapies have failed to improve survival. Treatment lactate improved cardiac function which may benefit this condition. Comprehensive hemodynamic assessment of administration in CS lacking, the mechanisms underlying cardiovascular effects not yet been elucidated. In study we aimed cardiometabolic treatment experimental ischemic CS. a randomized, blinded design, 20 female pigs (60 kg) were studied. Left main coronary artery...
Background Normal brain function depends on the ability of vasculature to increase blood flow regions with high metabolic demands. Impaired neurovascular coupling, such as local hyperemic response neuronal activity, may contribute poor neurological outcome after stroke despite successful recanalization, that is, futile recanalization. Methods and Results Mice implanted chronic cranial windows were trained for awake head-fixation before experiments. One-hour occlusion anterior middle cerebral...
A variant in the SLC4A3 anion exchanger has been identified as a novel cause of short QT syndrome (SQTS), but clinical importance SQTS or sudden cardiac death remains unknown.
Background Oral treatment with the exogenous ketone body 3‐hydroxybutyrate improves cardiac function in patients heart failure reduced ejection fraction, but ketosis is limited to 3 4 hours. Treatment (R)‐1,3‐butanediol (BD) provides prolonged healthy controls, hemodynamic and metabolic profile unexplored fraction. Methods Results This was a randomized, single‐blind, placebo‐controlled, crossover study. Transthoracic echocardiography venous blood samples were performed at baseline hourly for...
More than half of patients with ischemic stroke experience futile reperfusion, increasing the risk death and disabilities despite a successful recanalization. The reason behind this is debated, we aim to investigate cerebrovascular changes toward broader understanding these conditions. We hypothesize that reperfusion modifies expression profile in microvasculature spatial manner peri-infarct brain edema circulatory failure. investigated early (24-hour) gene parenchymal endothelial cells...
Abstract Background Cardiogenic shock complicating myocardial infarction (AMI-CS) is charactirized by reduced cardiac output (CO), poor end-organ perfusion, and high mortality. Current medical therapies have not significantly improved survival rates. Lactate, though often considered a toxic byproduct of anaerobic metabolism, serves as an oxygen efficient alternative, readily oxidizable substrate for the myocardium. Lactate infusion has been shown to improve CO left ventricular ejection...
Heterozygous mice (α2+/G301R mice) for the migraine-associated mutation (G301R) in Na+,K+-ATPase α2-isoform have decreased expression of cardiovascular α2-isoform. The α2+/G301R exhibit a pro-contractile vascular phenotype associated with left ventricular ejection fraction. However, integrated functional consequences this remain to be addressed vivo. We hypothesized that response α2-isoform-specific inhibition by ouabain is augmented leading reduced cardiac efficiency. Thus, we aimed assess...
Familial hemiplegic migraine type 2 (FHM2) is linked to Na,K-ATPase α isoform mutations, including that of G301R. Mice heterozygous for this mutation ([Formula: see text]) show cerebrovascular hypercontractility associated with amplified Src kinase signaling, and exaggerated neurovascular coupling. This study hypothesized targeting Na,K-ATPase-dependent phosphorylation pNaKtide would normalize cerebral perfusion coupling in [Formula: text] mice. The effect on blood flow was assessed using...
Targeted mild hypercapnia is a potential neuroprotective therapy after cardiac arrest. In this exploratory observational study, we aimed to explore the effects of targeted on cerebral microvascular resistance assessed by middle artery pulsatility index (MCA PI) and intracranial pressure estimated optic nerve sheath diameter (ONSD) in resuscitated out-of-hospital arrest (OHCA) patients. Comatose adults from OHCA were randomly allocated (PaCO2 50–55 mmHg) or normocapnia 35–45 for 24 h TAME...
Background Despite recanalization after ischemic stroke, neurovascular coupling, i.e., the local hyperaemic response to neuronal activity, is impaired in peri-ischemic brain regions. Reduced coupling may contribute neurological deterioration over time. The mechanism underlying dysfunctional following stroke largely unknown. Methods Mice implanted with chronic cranial windows were trained for awake head-fixation prior experiments. One hour occlusion of anterior middle cerebral artery branch...
Background: Despite vessel recanalization, up to 67% of ischemic-stroke patients experience futile reperfusion increasing the risk neurological morbidity and death. Arterial hypercontractility has been suggested underlie no-flow phenomenon, however, this remains be fully elucidated. Parenchymal arteries in area surrounding ischemic core (penumbra) display an elevated vascular tone due increased intracellular Ca 2+ sensitivity. Ischemia-reperfusion (IR) reduces Na + , K -ATPase activity is...