A5095092067- Cardiac Arrest and Resuscitation
- Diet and metabolism studies
- Mechanical Circulatory Support Devices
- Metabolism and Genetic Disorders
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Respiratory Support and Mechanisms
- Heart Rate Variability and Autonomic Control
- Pneumothorax, Barotrauma, Emphysema
Aarhus University
2024-2025
Aarhus University Hospital
2024-2025
Background Cardiogenic shock (CS) presents a medical challenge with limited treatment options. Positive end-expiratory pressure (PEEP) during mechanical ventilation has been linked clinical benefits in patients CS. This study investigated whether increasing PEEP levels could unload the left ventricle (LV) CS large animal model of LV-CS. Methods Left cardiogenic was induced 26 female pigs (60 kg) by microsphere injections into main coronary artery. In one study, protocol increased (5, 10, and...
Abstract Aim To describe the use of invasive mechanical ventilation core strategies, adjuvant treatments and occurrence barotrauma prolonged in ICU patients with COVID‐19 Denmark, retrospectively. Methods All ICUs admitting Denmark from 10 March 2020 to 2 April 2021 were invited participate. who received included data was retrospectively collected electronic patient records. Results A total 774 invasively ventilated during first two waves included; 70% males median age 69 years. 340 (51.5%)...
Cardiogenic shock (CS) is characterized by reduced cardiac output (CO), end-organ perfusion, and high mortality. Medical therapies have failed to improve survival. The ketone body 3-hydroxybutyrate (3-OHB) enhances function in heart failure CS. We aimed elucidate the cardiovascular cardiometabolic effects of 3-OHB treatment during In a randomized, assessor-blinded crossover design, we studied 16 female pigs (60 kg, 5 months age). CS was induced left main coronary artery microsphere...
Abstract Funding Acknowledgements Type of funding sources: Foundation. Main source(s): Novo Nordisk Foundation Independent Research Fund DK. Background Cardiogenic shock (CS) is a life-threatening disease with limited evidence-based treatment options. Treatment the ketone body 3-hydroxybutyrate (3-OHB) induces favorable hemodynamic effects in patients heart failure and CS. It increases cardiac output (CO) left ventricular (LV) ejection fraction (LVEF) while reducing filling pressures. Yet,...
Targeted mild hypercapnia is a potential neuroprotective therapy after cardiac arrest. In this exploratory observational study, we aimed to explore the effects of targeted on cerebral microvascular resistance assessed by middle artery pulsatility index (MCA PI) and intracranial pressure estimated optic nerve sheath diameter (ONSD) in resuscitated out-of-hospital arrest (OHCA) patients. Comatose adults from OHCA were randomly allocated (PaCO2 50–55 mmHg) or normocapnia 35–45 for 24 h TAME...