A5046931469- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Acute Myocardial Infarction Research
- Advanced X-ray and CT Imaging
- Cardiovascular Disease and Adiposity
- Heart Rate Variability and Autonomic Control
- Advanced MRI Techniques and Applications
- Hemodynamic Monitoring and Therapy
- Cerebrovascular and Carotid Artery Diseases
- Infective Endocarditis Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Radiation Dose and Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Lipoproteins and Cardiovascular Health
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Non-Invasive Vital Sign Monitoring
- Cardiovascular and exercise physiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
Monash University
2015-2024
Monash Health
2015-2024
Austin Health
2024
The University of Melbourne
2006-2024
Adaptix (United Kingdom)
2023
University of Oxford
2023
Monash Medical Centre
2013-2022
Rush University Medical Center
2015-2022
George Mason University
2021-2022
Michigan State University
2022
Using a noninvasive technique we have investigated the effect of 4 wk exercise training on total systemic arterial compliance (SAC) in 13 previously sedentary young males. SAC is assessed from simultaneous measurements ascending aortic blood velocity using Doppler velocimetry and surrogate estimates root pressure obtained by applanation tonometry right carotid artery. Subsequent calibration waveform linear interpolation against brachial pressures measured sphygmomanometrically. Exercise...
Abstract —Aerobic exercise training increases arterial compliance and reduces systolic blood pressure, but the effects of muscular strength on mechanical properties are unknown. We compared whole body compliance, aortic impedance, stiffness (measured by β-index carotid pulse pressure divided normalized expansion [Ep]), wave velocity, left ventricular parameters in 19 strength–trained athletes (mean±SD age, 26±4 years) sedentary controls (26±5 years). Subjects were healthy, non-steroid-using,...
1. Repeatability of measurements arterial compliance and flow-mediated dilation the brachial artery has been infrequently reported, despite increasing use in interventional risk-factor modification studies. Furthermore, little is known about interrelationships various indices. The purposes this study were to determine repeatability a range 2. Fifty healthy volunteers, 20 men 30 women, aged 20–70 (mean 46.5) years, studied on two occasions, using an identical protocol, at mean interval 2.5...
Exercise training elevates arterial compliance at rest, but the effects of acute exercise in this regard are unknown. This study investigated a single, 30-min bout cycling 65% maximal oxygen consumption on indexes compliance. Whole body determined noninvasively from simultaneous measurements aortic flow and carotid pressure was elevated (66 ± 26%) 0.5 h postexercise ( P = 0.04), followed by decline to baseline 1 after exercise. Aortic pulse-wave velocity, which is inversely related...
The possibility that the heightened cardiovascular risk associated with menopause can be reduced by increasing dietary isoflavone intake was tested in 17 women measuring arterial compliance, an index of elasticity large arteries such as thoracic aorta. Compliance diminishes age and menopause. An initial 3- to 4-week run-in period a 5-week placebo were followed two periods active treatment 40 mg then 80 isoflavones derived from red clover containing genistein, daidzein, biochanin,...
Background Large artery mechanical properties are a major determinant of pulse pressure and cardiovascular outcome. Sex differences in these may underlie the variation risk profile between men women, relation to age. Objective To investigate sex age-related stiffening large arteries. Design Cross-sectional. Methods One hundred twenty healthy women were recruited divided equally into tertiles by age: young (mean ± SD, 23 5 years), middle-age (47 3 years) older (62 7 years). Lipids, mean...
Adenosine stress computed tomography myocardial perfusion imaging (CTP) is an emerging non-invasive method for detecting ischaemia. Its value when compared with fractional flow reserve (FFR), a highly accurate index of ischaemia, unknown. Our aim was to determine the diagnostic accuracy CTP and its incremental used coronary angiography (CTA) ischaemia FFR. Forty-two patients (126 vessel territories), who had at least one ≥50% angiographic stenosis on invasive considered non-urgent...
Central arterial waveforms and related indices of large artery properties can be determined with relative ease. This would make them an attractive adjunct in the risk stratification for cardiovascular disease. Although they have been associated some classical factors presence coronary disease, their prospective value predicting outcomes is unknown. The present study predictive disease-free survival as compared noninvasive brachial blood pressure alone a population elderly female hypertensive...
The effects of large changes in hemoglobin concentration were studied rainbow trout fresh water between 8 and 14 C. Anemia was produced by injecting phenylhydrazine hydrochloride or replacing blood with either saline plasma.No significant observed the rate oxygen consumption, arterial venous tensions, ventilation volume, inspired expired dorsal aortic pressure. primary compensatory mechanism invoked an increase cardiac output, which accomplished almost entirely increases stroke volume....
BackgroundPrimary spontaneous pneumothorax occurs in otherwise healthy young patients. Optimal management is not defined and often results prolonged hospitalisation. Data on efficacy of ambulatory options are poor. We aimed to describe the duration hospitalisation safety compared with standard care.MethodsIn this open-label, randomised controlled trial, adults (aged 16–55 years) symptomatic primary were recruited from 24 UK hospitals during a period 3 years. Patients randomly assigned (1:1)...
Significance Statement In patients with CKD, higher serum phosphate levels are associated increased fibroblast growth factor 23 (FGF23) levels, arterial calcification, and cardiovascular mortality. Limited trials assessing phosphate-lowering therapy have reported modest efficacy in lowering FGF23 during short-term follow-up CKD; the effect of these agents on markers remains uncertain. This randomized trial involving 278 participants stage 3b or 4 CKD (mean age 63 years) found no significant...
Background: Little is known about clinical characteristics, hospital course, and longitudinal outcomes of patients with cardiogenic shock (CS) related to heart failure (HF-CS) compared acute myocardial infarction (AMI; CS AMI [AMI-CS]). Methods: We examined in-hospital 1-year 520 (219 AMI-CS, 301 HF-CS) consecutive (January 3, 2017–December 31, 2019) in a single-center registry. Results: Mean age was 61.5±13.5 years, 71% were male, 22% Black patients, 63% had chronic kidney disease. The...
The mechanisms relating pulse pressure to cardiovascular outcome may include surrogacy for coronary disease severity. Although is typically measured at the brachial artery, central and its principal determinant, large-artery stiffness, relate more closely This study aimed determine relationships between stiffness carotid blood pressures artery One hundred fourteen male patients with (age 60+/-8 years, mean+/-SD) 57 age-matched healthy controls 59+/-9 years) were recruited. Patients...