Najib M. Rahman
A5059272486- Pleural and Pulmonary Diseases
- Ultrasound in Clinical Applications
- Lung Cancer Diagnosis and Treatment
- Occupational and environmental lung diseases
- Trauma Management and Diagnosis
- Pneumothorax, Barotrauma, Emphysema
- Medical Imaging and Pathology Studies
- Respiratory Support and Mechanisms
- Amoebic Infections and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Long-Term Effects of COVID-19
- Radiology practices and education
- Case Reports on Hematomas
- Congenital Diaphragmatic Hernia Studies
- Soft tissue tumor case studies
- Airway Management and Intubation Techniques
- COVID-19 Clinical Research Studies
- Radiation Dose and Imaging
- Pericarditis and Cardiac Tamponade
- Radiomics and Machine Learning in Medical Imaging
- Atomic and Subatomic Physics Research
- Intensive Care Unit Cognitive Disorders
- RNA modifications and cancer
- Tracheal and airway disorders
- RNA and protein synthesis mechanisms
University of Oxford
2016-2025
Churchill Hospital
2016-2025
Oxford BioMedica (United Kingdom)
2016-2025
Oxford University Hospitals NHS Trust
2016-2025
National Institute for Health Research
2016-2025
Science Oxford
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Oxford Biomedical Research
2011-2024
Oxford Centre for Diabetes, Endocrinology and Metabolism
2013-2024
Respiratory Clinical Trials
2020-2024
### Monitoring, precautions and complications ### Hypoxaemia ### Cardiac arrhythmias ### Bleeding complications
More than 30% of patients with pleural infection either die or require surgery. Drainage infected fluid is key to successful treatment, but intrapleural fibrinolytic therapy did not improve outcomes in an earlier, large, randomized trial.We conducted a blinded, 2-by-2 factorial trial which 210 were randomly assigned receive one four study treatments for 3 days: double placebo, tissue plasminogen activator (t-PA) and DNase, t-PA DNase placebo. The primary outcome was the change opacity,...
<h3>Context</h3>Malignant pleural effusion causes disabling dyspnea in patients with a short life expectancy. Palliation is achieved by fluid drainage, but the most effective first-line method has not been determined.<h3>Objective</h3>To determine whether indwelling catheters (IPCs) are more than chest tube and talc slurry pleurodesis (talc) at relieving dyspnea.<h3>Design</h3>Unblinded randomized controlled trial (Second Therapeutic Intervention Malignant Effusion Trial [TIME2]) comparing...
BackgroundThe medium-term effects of Coronavirus disease (COVID-19) on organ health, exercise capacity, cognition, quality life and mental health are poorly understood.MethodsFifty-eight COVID-19 patients post-hospital discharge 30 age, sex, body mass index comorbidity-matched controls were enrolled for multiorgan (brain, lungs, heart, liver kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary test (CPET), life, cognitive assessments.FindingsAt 2–3...
The impact of COVID-19 on physical and mental health employment after hospitalisation with acute disease is not well understood. aim this study was to determine the effects COVID-19-related employment, identify factors associated recovery, describe recovery phenotypes. Post-hospitalisation (PHOSP-COVID) a multicentre, long-term follow-up adults (aged ≥18 years) discharged from hospital in UK clinical diagnosis COVID-19, involving an assessment between 2 7 months discharge, including detailed...
Thoracoscopy under local anaesthetic and intravenous sedation, also known as thoracoscopy, medical thoracoscopy or pleuroscopy, is increasingly being performed by chest physicians in the UK. In 1999, 11 centres across UK offered a service, increasing to 17 May 20041 37 2009 (Dr N Downer, personal communication). This document, which will use term ‘local thoracoscopy’, aims consider following issues make appropriate recommendations on basis of evidence where available: Creation this...
No effective pharmacological or non-pharmacological interventions exist for patients with long COVID. We aimed to describe recovery 1 year after hospital discharge COVID-19, identify factors associated patient-perceived recovery, and potential therapeutic targets by describing the underlying inflammatory profiles of previously described clusters at 5 months discharge.
Malignant pleural effusion affects more than 750,000 persons each year across Europe and the United States. Pleurodesis with administration of talc in hospitalized patients is most common treatment, but indwelling catheters placed for drainage offer an ambulatory alternative. We examined whether administered through catheter was effective at inducing pleurodesis use alone.Over a period 4 years, we recruited malignant 18 centers Kingdom. After insertion catheter, underwent regularly on...
Section 3: Clinical features which predict the presence of mesothelioma Recommendations 4: Staging systems Recommendation 5: Imaging modalities for diagnosing and staging 6: Pathological diagnosis
<h3>Importance</h3> For treatment of malignant pleural effusion, nonsteroidal anti-inflammatory drugs (NSAIDs) are avoided because they may reduce pleurodesis efficacy. Smaller chest tubes be less painful than larger tubes, but efficacy in has not been proven. <h3>Objective</h3> To assess the effect tube size and analgesia (NSAIDs vs opiates) on pain clinical related to patients with effusion. <h3>Design, Setting, Participants</h3> A 2×2 factorial phase 3 randomized trial among 320 requiring...
### Spontaneous pneumothorax #### Acute management for spontaneous ##### Recommendations Good practice points Optimal after the resolution of a first episode and ongoing air leak point
Abstract Malignant pleural effusion (MPE) is a common complication of thoracic and extrathoracic malignancies associated with high mortality elevated costs to healthcare systems. Over the last decades understanding pathophysiology mechanisms, diagnostic techniques optimal treatment intervention in MPE have been greatly advanced by recent high-quality research, leading an ever less invasive approach more personalized management. Despite number management options, including talc pleurodesis,...
Abstract Viral clearance, antibody response and the mutagenic effect of molnupiravir has not been elucidated in at-risk populations. Non-hospitalised participants within 5 days SARS-CoV-2 symptoms randomised to receive (n = 253) or Usual Care 324) were recruited study viral dynamics on whole genome sequence from 1437 genomes. Molnupiravir accelerates load decline, but virus is detectable by Day most cases. At 14 (9 post-treatment), associated with significantly higher persistence lower...
Background The optimal management for spontaneous pneumothorax (SP) remains contentious, with various proposed approaches. This joint clinical practice guideline from the ERS, EACTS and ESTS societies provides evidence-based recommendations of SP. Methods multidisciplinary Task Force addressed 12 key questions on pneumothorax, using ERS methodology development. Systematic searches were performed in MEDLINE Embase. Evidence was synthesised by conducting meta-analyses, if possible, or...
<h3>Background:</h3> Malignant pleural effusion (MPE) is a common clinical problem with described investigation pathways. While thoracic ultrasound (TUS) has been shown to be accurate in fluid detection, its use the diagnosis of malignant disease not assessed. A study was undertaken assess diagnostic accuracy TUS differentiating and benign disease. <h3>Methods:</h3> 52 consecutive patients suspected MPE underwent contrast-enhanced CT (CECT). used surfaces using previously published imaging...
Background Pleural infection is common, and has a >30% major morbidity mortality—particularly when caused by Gram-negative, Staphylococcus aureus or mixed aerobic pathogens. Standard pleural fluid culture negative in ∼40% of cases. Culturing blood bottles may increase microbial yield, cheap easy to perform. Objectives To determine whether inoculating into increases the positivity over standard laboratory culture, assess optimum volume inoculum introduce. Methods 62 patients with were...