A5000799925- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Diet, Metabolism, and Disease
- Advanced MRI Techniques and Applications
- Hepatitis C virus research
- Pediatric Hepatobiliary Diseases and Treatments
- Diet and metabolism studies
- MRI in cancer diagnosis
- Endoplasmic Reticulum Stress and Disease
- Pancreatitis Pathology and Treatment
- Metabolism and Genetic Disorders
- Systemic Sclerosis and Related Diseases
- Pancreatic and Hepatic Oncology Research
- AI in cancer detection
- Cardiovascular Function and Risk Factors
- Hepatitis Viruses Studies and Epidemiology
- Alcohol Consumption and Health Effects
- Metabolomics and Mass Spectrometry Studies
- Folate and B Vitamins Research
- Hepatitis B Virus Studies
- Radiomics and Machine Learning in Medical Imaging
- Lipid metabolism and disorders
Oxford BioMedica (United Kingdom)
2016-2025
University of Oxford
2016-2025
Oxford University Hospitals NHS Trust
2015-2024
John Radcliffe Hospital
2013-2023
National Health Service
2021-2023
National Institute for Health Research
2020-2023
Université d'Angers
2023
Amsterdam University Medical Centers
2023
University of Warwick
2023
University of Leicester
2023
BackgroundThe medium-term effects of Coronavirus disease (COVID-19) on organ health, exercise capacity, cognition, quality life and mental health are poorly understood.MethodsFifty-eight COVID-19 patients post-hospital discharge 30 age, sex, body mass index comorbidity-matched controls were enrolled for multiorgan (brain, lungs, heart, liver kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary test (CPET), life, cognitive assessments.FindingsAt 2–3...
With the increasing prevalence of liver disease worldwide, there is an urgent clinical need for reliable methods to diagnose and stage pathology. Liver biopsy, current gold standard, invasive limited by sampling observer dependent variability. In this study, we aimed assess diagnostic accuracy a novel magnetic resonance protocol tissue characterisation.We conducted prospective study comparing our technique against biopsy. The individual components scanning were T1 mapping, proton...
Type 2 diabetes (T2D) and obesity are associated with nonalcoholic fatty liver disease, cardiomyopathy, cardiovascular mortality. Both show stronger links between ectopic visceral fat deposition, an increased cardiometabolic risk compared subcutaneous fat.
<h3>Background & Aims</h3> Multiparametric magnetic resonance (MR) imaging has been demonstrated to quantify hepatic fibrosis, iron, and steatosis. The aim of this study was determine if MR can be used predict negative clinical outcomes in liver disease patients. <h3>Methods</h3> Patients with chronic (n=112) were recruited for data on the development related events collected by medical records review. median follow-up 27months. analysed blinded Liver Inflammation Fibrosis score (LIF; <1,...
Abstract Background & Aims The diagnosis of non‐alcoholic steatohepatitis and fibrosis staging are central to fatty liver disease assessment. We evaluated multiparametric magnetic resonance in the assessment using histology as standard disease. Methods Seventy‐one patients with suspected were recruited within 1 month biopsy. Magnetic data used define inflammation score ( LIF 0‐4). Biopsies assessed for steatosis, lobular inflammation, ballooning classified or simple mild significant...
ABSTRACT Background and Aims The performance of non‐invasive liver tests (NITs) is known to vary across settings subgroups. We systematically evaluated whether the three NITs in detecting advanced fibrosis patients with metabolic dysfunction‐associated steatotic disease (MASLD) varies age, sex, body mass index (BMI), type 2 diabetes mellitus (T2DM) status or enzymes. Methods Data from 586 adult LITMUS Metacohort participants histologically characterised MASLD were included. diagnostic...
In most populations a greater proportion of men have hepatic steatosis than women. Sex-specific differences in dietary fatty acid (FA) metabolism not been well characterized. We compared fasting and postprandial FA synthesis (de novo lipogenesis [DNL]) oxidation women.Fasting was studied 22 healthy (n = 11) women with similar age, body mass index, liver fat content using metabolic substrates labeled stable-isotope tracers ((2)H2O [U(13)C]palmitate). Dietary assessed by appearance (13)C into...
Abstract Background The medium-term effects of Coronavirus disease (COVID-19) on multiple organ health, exercise capacity, cognition, quality life and mental health are poorly understood. Methods Fifty-eight COVID-19 patients post-hospital discharge 30 comorbidity-matched controls were prospectively enrolled for multiorgan (brain, lungs, heart, liver kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary test (CPET), life, cognitive assessments. Findings...
Introduction Late stage clinical trials in non-alcoholic steatohepatitis (NASH) are currently required by the FDA to use liver biopsy as a primary endpoint. The well-reported limitations with biopsy, such associated risks and sampling error, coupled patient preference, driving investigation into non-invasive alternatives. MRI-derived biomarkers proton density fat fraction (PDFF) iron-corrected T1 mapping (cT1) gaining traction emerging alternatives for NASH. Our aim was explore correlations...
Abstract Background and Aims Elevated serum ferritin is common in NAFLD , associated with more advanced disease increased mortality. Hyperferritinaemia often attributed to inflammation, while other conditions closely reflects body iron stores. The aim of this study was clarify the underlying cause hyperferritinaemia . Methods Ferritin levels were examined markers status, inflammation liver injury across clinical spectrum using blood, tissue magnetic resonance ( MR ) imaging. A separate...
Purpose To propose a simple multicompartment model of the liver and use Bloch-McConnell simulations to demonstrate effects iron fibrosis on shortened-MOLLI (shMOLLI) T1 measurements. Liver values have shown sensitivity inflammation fibrosis, but are also affected by hepatic content. Modified Look-Locker inversion recovery (MOLLI) measurements biased lower T2 associated with high iron. Materials Methods A tissue was generated consisting cells extracellular fluid (ECF), iron-dependent...
Purpose To characterize the effect of fat on modified Look–Locker inversion recovery (MOLLI) T 1 maps liver. The balanced steady‐state free precession (bSSFP) sequence causes water and signals to have opposite phase when repetition time (TR) = 2.3 msec at 3T. In voxels that contain both water, MOLLI measurement is influenced by choice TR. Materials Methods measurements liver were simulated using Bloch equations while varying hepatic lipid content (HLC). Phantom scans performed margarine...