A5000714600- Clinical Nutrition and Gastroenterology
- Organ and Tissue Transplantation Research
- Immune Cell Function and Interaction
- Nutrition and Health in Aging
- Intestinal and Peritoneal Adhesions
- IL-33, ST2, and ILC Pathways
- Inflammatory Bowel Disease
- Organ Transplantation Techniques and Outcomes
- Abdominal Surgery and Complications
- Dialysis and Renal Disease Management
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- Immunotherapy and Immune Responses
- Dysphagia Assessment and Management
- Biomedical Ethics and Regulation
- Transplantation: Methods and Outcomes
- Central Venous Catheters and Hemodialysis
- Intestinal Malrotation and Obstruction Disorders
- Helicobacter pylori-related gastroenterology studies
- Intraperitoneal and Appendiceal Malignancies
- Reproductive System and Pregnancy
- Intensive Care Unit Cognitive Disorders
- Pregnancy and Medication Impact
- Organ Donation and Transplantation
- Gastric Cancer Management and Outcomes
Oxford University Hospitals NHS Trust
2016-2024
Waikato Hospital
2024
University of Oxford
2013-2023
Churchill Hospital
2016-2023
John Radcliffe Hospital
2011-2022
Oxford BioMedica (United Kingdom)
2019-2021
National Institute for Health Research
2020
Oxford Biomedical Research
2019
Rockingham General Hospital
2017
Salford Royal NHS Foundation Trust
2014-2017
Tissue-resident memory T (TRM) cells provide key adaptive immune responses in infection, cancer, and autoimmunity. However, transcriptional heterogeneity of human intestinal TRM remains undefined. Here, we investigate functional through study donor-derived from transplant recipients. Single-cell profiling identifies two states CD8+ cells, delineated by ITGAE ITGB2 expression. We define a signature discriminating these populations, including differential expression cytotoxicity-...
Immune responses at the intestinal mucosa must allow for host protection whilst simultaneously avoiding inappropriate inflammation. Although much work has focused on innate immune functionality of hematopoietic cells, non-hematopoietic cell populations - including epithelial and stromal cells are now recognized as playing a key role in defense this site. In study we examined capacity primary human (iSCs). CD90(+) iSCs isolated from colonic expressed wide array receptors functionally...
Background: The safety of percutaneous endoscopic gastrostomy (PEG) insertion in amyotrophic lateral sclerosis (ALS) patients with significant respiratory compromise has been questioned. Objectives: To review the characteristics an ALS clinic patient cohort undergoing PEG, and introduction a risk stratification tool procedural adaptations for higher-risk individuals. Methods: Patients PEG were analysed (n = 107). Cases stratified as underwent semi-recumbent position, minimising sedation,...
Autophagy is important in immune cells as a means of disposing pathogens and connecting with the antigen presentation machinery to facilitate priming initiation correctly targeted adaptive response. While Toll-like receptors (TLRs) are known regulate autophagy this context, extent which other pattern recognition (PRRs) involved has been unclear. NOD2 an intracellular PRR Nod-like receptor (NLR) family that notable variants ligand domain associated Crohn disease (CD). Our recent study shows...
To report our experience with the combination of radical surgical excision and intestinal transplantation in patients recurrent pseudomyxoma peritonei (PMP) not amenable to further cytoreductive surgery (CRS).CRS heated intraoperative peritoneal chemotherapy are effective treatments for many PMP. In extensive small bowel involvement or nonresectable recurrence, disease progression results obstruction, nutritional failure, fistulation, resulting abdominal wall failure.Between 2013 2022, PMP...
Abstract Purpose of Review This article aims to review published outcomes associated with full-thickness vascularized abdominal wall transplantation, particular emphasis on advances in the field last 3 years. Recent Findings Forty-six transplants have been performed 44 patients worldwide. Approximately 35% transplant recipients will experience at least one episode acute rejection first year after transplant, compared rates 87.8% and 72.7% for hand face respectively. evidence suggests that...
This survey of centers caring for patients receiving home parenteral nutrition (HPN) was conducted to assess the impact coronavirus disease 2019 (COVID-19) crisis on management these regarding provision care, monitoring, regular follow-up, and any changes service infrastructure.A devised publically published Research Electronic Data Capture database system, with individual responding a public link.A total 78 adult pediatric worldwide contributed survey, representing ≥3500 patients'...
The direct effect of the coronavirus disease 2019 (COVID-19) pandemic on patients with intestinal failure (IF) has not been described.We conducted a nationwide study UK IF centers to evaluate infection rates, presentations, and outcomes in types 2 3 IF.A total 45 contracted COVID-19 between March August 2020; this included 26 2191 (1.2%) home parenteral nutrition (HPN)-dependent adults 19 298 (6.4%) hospitalized type IF. proportion receiving nursing care for HPN administration was higher...