A5037572716- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Clinical Nutrition and Gastroenterology
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Organ and Tissue Transplantation Research
- Liver Disease Diagnosis and Treatment
- Abdominal Surgery and Complications
- Hepatocellular Carcinoma Treatment and Prognosis
- Neurological Complications and Syndromes
- Pediatric Hepatobiliary Diseases and Treatments
- Intestinal Malrotation and Obstruction Disorders
- Hepatitis C virus research
- Cytomegalovirus and herpesvirus research
- Metabolism and Genetic Disorders
- Enhanced Recovery After Surgery
- Gallbladder and Bile Duct Disorders
- Congenital Anomalies and Fetal Surgery
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Infant Nutrition and Health
- Liver Diseases and Immunity
- Viral-associated cancers and disorders
- Renal and Vascular Pathologies
- Nutrition and Health in Aging
Duke University
2015-2025
Duke University Hospital
2010-2025
Duke Medical Center
2015-2024
Yahoo (United Kingdom)
2024
Miami Transplant Institute
2023
University of Miami
2023
Jackson Memorial Hospital
2023
University of Pittsburgh Medical Center
2021-2022
Columbia University
2022
University of Michigan–Ann Arbor
2021
A report from a high-volume single center indicated survival benefit of receiving kidney transplant an HLA-incompatible live donor as compared with remaining on the waiting list, whether or not deceased was received. The generalizability that finding is unclear.
In a prospective, multicenter, open-label study, de novo liver transplant patients were randomized at day 30±5 to (i) everolimus initiation with tacrolimus elimination (TAC Elimination) (ii) reduced-exposure (EVR+Reduced TAC) or (iii) standard-exposure Control). Randomization TAC Elimination was terminated prematurely due higher rate of treated biopsy-proven acute rejection (tBPAR). EVR+Reduced noninferior Control for the primary efficacy endpoint (tBPAR, graft loss death 12 months...
This document was developed through the collaborative efforts of Society Critical Care Medicine, American College Chest Physicians, and Association Organ Procurement Organizations. Under auspices these societies, a multidisciplinary, multi-institutional task force convened, incorporating expertise in critical care medicine, organ donor management, transplantation. Members were divided into 13 subcommittees, each focused on one following general or organ-specific areas: death determination...
To compare conventional low-temperature storage of transplant donor livers [static cold (SCS)] with the organs at physiological body temperature [normothermic machine perfusion (NMP)].
Myofibroblastic hepatic stellate cells (MF-HSC) are derived from quiescent (Q-HSC). Q-HSC express certain epithelial cell markers and have been reported to form junctional complexes similar cells. We shown that Hedgehog (Hh) signaling plays a key role in HSC growth. Because Hh ligands regulate epithelial-to-mesenchymal transition (EMT), we determined whether EMT then assessed these change as into MF-HSC the process is modulated by signaling. were isolated healthy livers cultured promote...
In Brief Objective: Review the clinical results of 24 years intestinal lengthening procedures at one institution. Methods: Retrospective review a single center experience comparing outcome 2 (Bianchi and serial transverse enteroplasty [STEP]) in terms survival, total parenteral nutrition (TPN) weaning, complications. Results: Sixty-four patients, including 14 adults, underwent 43 Bianchi 34 STEP between 1982 2007. Three patients had prior isolated liver transplants. The median (range)...
To evaluate the efficacy of a low-dose chemotherapy regimen in children with Epstein-Barr virus (EBV) -positive, post-transplantation lymphoproliferative disease (PTLD) after organ transplantation who have experienced failure front-line therapy for PTLD.Eligible patients received cyclophosphamide (600 mg/m2 intravenous 1 day) and prednisone (2 mg/kg orally 5 days) every 3 weeks six cycles.Thirty-six treated on study were assessable analyses. Front-line therapies PTLD before entry included...
Incompatible live donor kidney transplantation (ILDKT) offers a survival advantage over dialysis to patients with anti-HLA donor-specific antibody (DSA). Program-specific reports (PSRs) fail account for ILDKT, placing this practice at regulatory risk. We collected DSA data, categorized as positive Luminex, negative flow crossmatch (PLNF) (n = 185), flow, cytotoxic (PFNC) 536) or (PCC) 304), from 22 centers. tested associations between DSA, graft loss and mortality after adjusting PSR model...
In a 24-month prospective, randomized, multicenter, open-label study, de novo liver transplant patients were randomized at 30 days to everolimus (EVR) + Reduced tacrolimus (TAC; n = 245), TAC Control (n 243) or Elimination 231). Randomization was stopped prematurely due significantly higher rate of treated biopsy-proven acute rejection (tBPAR). The incidence the primary efficacy endpoint, composite failure tBPAR, graft loss death postrandomization similar with EVR (10.3%) (12.5%) month 24...
Inflammatory bowel disease (IBD) is associated with primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) can recur or develop de novo after orthotopic liver transplantation (OLT). The aim of this study was to investigate the incidence severity IBD perform a multivariate analysis for possible risk factors. In retrospective study, 91 patients transplanted PSC AIH, without prior colectomy, were included. Sixty PSC, 31 AIH. activity before OLT other factors analysed in model....
To evaluate the effect of pretransplant bridging locoregional therapy (LRT) on hepatocellular carcinoma (HCC) recurrence and survival after liver transplantation (LT) in patients meeting Milan criteria (MC).Pre-LT LRT mitigates tumor progression waitlist dropout HCC within MC, but data its impact post-LT remain limited.Recurrence-free were compared among 3601 MC with without utilizing competing risk Cox regression consecutive from 20 US centers (2002-2013).Compared 747 LT recipients not...
Background and Aims The Organ Procurement Transplantation Network recently approved liver transplant (LT) prioritization for patients with hepatocellular carcinoma (HCC) beyond Milan Criteria (MC) who are down‐staged (DS) locoregional therapy (LRT). We evaluated post‐LT outcomes, predictors of down‐staging, the impact LRT in beyond‐MC HCC from U.S. Multicenter Transplant Consortium (20 centers, 2002‐2013). Approach Results Clinicopathologic characteristics, overall survival (OS),...
The aim of the study was to determine rate, predictors, and impact complete pathologic response (cPR) pretransplant locoregional therapy (LRT) in a large, multicenter cohort hepatocellular carcinoma (HCC) patients undergoing liver transplantation (LT).LRT is used mitigate waitlist dropout for with HCC awaiting LT. Degree tumor necrosis found on explant has been associated recurrence overall survival, but not evaluated study.Comparisons were made among receiving pre-LT LRT (n = 802) without...
Parenteral nutrition sustains life in patients with intestinal failure. However, some experience life-threatening complications from parenteral nutrition, and these individuals transplantation may be lifesaving.This is a retrospective review of 28 consecutive isolated small bowel transplants performed eight adults 20 children between December 1993 June 1998 at the University Nebraska Medical Center.The 1-yr patient graft survivals were 93% 71%, respectively. The causes loss hyperacute...
Abstract OBJECTIVE: Parenteral nutrition sustains life in patients with intestinal failure. However, some experience life-threatening complications from parenteral nutrition, and these individuals transplantation may be lifesaving. METHODS: This is a retrospective review of 28 consecutive isolated small bowel transplants performed eight adults 20 children between December 1993 June 1998 at the University Nebraska Medical Center. RESULTS: The 1-yr patient graft survivals were 93% 71%,...
To analyze outcomes in children with intestinal failure treated by our Intestinal Rehabilitation Program (IRP) a 4-year period.A total of 51 parenteral nutrition (PN)-dependent patients (20 male) were enrolled the IRP. Median age was 1.7 years, primary diagnoses being gastroschisis, necrotizing enterocolitis, volvulus, and congenital atresia. small bowel length 35 cm, majority having only jejunum as remaining anatomy. Thirty-six had liver disease characterized cirrhosis, advance bridging...
Background1-year data from this trial showed the noninferiority of a novel once-daily extended-release tacrolimus (LCPT; Envarsus XR) to immediate-release (IR-Tac) twice daily after kidney transplantation.Study DesignFinal 24-month analysis 2-armed, parallel-group, randomized, double-blind, double-dummy, multicenter, phase 3 trial.Setting & Participants543 de novo recipients randomly assigned LCPT (n = 268) or IR-Tac 275); 507 (93.4%) completed study.InterventionLCPT tablets once at 0.17...