A5076325081- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Dialysis and Renal Disease Management
- Genetic and Kidney Cyst Diseases
- Renal Diseases and Glomerulopathies
- Organ Donation and Transplantation
- Biomedical Research and Pathophysiology
- Genetic Syndromes and Imprinting
- Pharmacological Effects and Toxicity Studies
- Transplantation: Methods and Outcomes
- Electrolyte and hormonal disorders
- Metabolism and Genetic Disorders
- Parathyroid Disorders and Treatments
- Liver Disease and Transplantation
- Renal function and acid-base balance
- Chronic Kidney Disease and Diabetes
- Advanced Glycation End Products research
- Muscle and Compartmental Disorders
- Renal and Vascular Pathologies
- Pregnancy and Medication Impact
- Diabetes and associated disorders
- Neurological Complications and Syndromes
- Diet and metabolism studies
- Cardiac Ischemia and Reperfusion
- Drug-Induced Hepatotoxicity and Protection
Pomeranian Medical University
2016-2025
AstraZeneca (Sweden)
2021
University of Szczecin
2004-2013
Tripoli Central Hospital
2006
Medical University of Silesia
2005-2006
University of Applied Science and Technology
2006
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2006
Heinrich Heine University Düsseldorf
2006
Düsseldorf University Hospital
2006
Maastricht University Medical Centre
2006
This Phase III randomized trial examined efficacy and safety of a novel once-daily extended-release tacrolimus formulation (LCP-Tacro [LCPT]) versus twice-daily in de novo kidney transplantation. Primary end point was proportion patients with treatment failure (death, graft failure, biopsy-proven acute rejection or lost to follow-up) within 12 months. Starting doses were, LCPT: 0.17 mg/kg/day twice-daily: 0.1 mg/kg/day; 543 were randomized, n = 268; 275. At months 18.3% 19.6%; the upper 95%...
Sarcopenia is a condition of multifaceted etiology arising in many elderly people. In patients with chronic kidney, the loss muscle mass much more intensive and first signs sarcopenia are observed younger than it expected. It associated whole-body protein-energy deficiency called wasting (PEW). seems to be one major factors limiting patient's autonomy as well decreasing quality life. If cannot treated simple methods requiring some knowledge devotion, we will fail save who die due...
Phase III noninferiority trial examining efficacy and safety of converting stable renal transplant recipients from twice-daily tacrolimus to a novel extended-release once-daily formulation (LCPT) with controlled agglomeration technology. Controls maintained twice daily. The primary endpoint was proportion patients failures (death, graft failure, locally read biopsy-proven acute rejection [BPAR], or loss follow-up) within 12 months. Starting LCPT dose 30% lower (15% for blacks) than...
Background1-year data from this trial showed the noninferiority of a novel once-daily extended-release tacrolimus (LCPT; Envarsus XR) to immediate-release (IR-Tac) twice daily after kidney transplantation.Study DesignFinal 24-month analysis 2-armed, parallel-group, randomized, double-blind, double-dummy, multicenter, phase 3 trial.Setting & Participants543 de novo recipients randomly assigned LCPT (n = 268) or IR-Tac 275); 507 (93.4%) completed study.InterventionLCPT tablets once at 0.17...
Overactivation of Src has been linked to the pathogenesis autosomal dominant polycystic kidney disease (ADPKD). This phase 2, multisite study assessed efficacy and safety bosutinib, an oral dual Src/Bcr-Abl tyrosine kinase inhibitor, in patients with ADPKD. Patients ADPKD, eGFR≥60 ml/min per 1.73 m 2 , total volume ≥750 ml were randomized 1:1:1 bosutinib 200 mg/d, 400 or placebo for ≤24 months. The primary endpoint was annualized rate enlargement treated ≥2 weeks who had at least one...
Renal replacement therapy is associated with reduced physical activity. The aim of the study was to assess relationship between regular activity performed use virtual reality and occurrence symptoms anxiety depression in hemodialysis patients. involved 85 patients from dialysis station at Department Nephrology, Transplantology Internal Medicine PUM. examined were randomly divided into group control group. consisted undergoing renal by hemodialysis, whose task perform VR exercises using...
The problem of reduced physical activity in patients with stage 5 Chronic Kidney Disease (CKD) is becoming more and interesting the medical community. One innovative solutions that can significantly increase patients' motivation to exercise integration training virtual reality (VR) technology during hemodialysis. aim this study was comprehensively assess impact regular using on concentration plasma PCSK9 protein TNF-α CKD treated A prototype NefroVR system used research project. group...
This is the first report on epidemiology of biopsy-proven kidney diseases in Poland.The Polish Registry Renal Biopsies has collected information all (n = 9394) native renal biopsies performed Poland from 2009 to 2014. Patients' clinical data at time biopsy, and histopathological diagnoses were used for epidemiological clinicopathologic analysis.There was a gradual increase number per million people (PMP) year 2009-14, starting 36 PMP 44 A considerable variability between provinces mean...
AbstractCase Report: Intentional intoxication with natural hallucinogenic substances such as mushrooms continues to be a major problem in the US and Europe, particularly harbor complex of northwest Poland (Pomerania). A case is described Psilocybe an 18-year-old man resulting Wolff-Parkinson-White syndrome, arrhythmia, myocardial infarction. The indole concentrations may predict risk for adverse central nervous system cardiac toxicity.
Introduction: Physical activity during pregnancy is established to derive clinically meaningful improvements in pregnancy, childbirth, and postpartum health outcomes. Evidence-based pre-screening tools have been developed support the implementation of physical programmes, enhance communication between care providers, exercise professionals pregnant women. The Get Active Questionnaire for Pregnancy (GAQ-P) Health Care Provider Consultation Form Prenatal Activity (HCPCF) empower women identify...
Renal ischemia-reperfusion (I-R) injury (IRI) is an inseparable feature of organ transplantation and may have a negative impact on the graft, its function survival. Acute tubular necrosis, which reversible thanks to regenerative capacity renal epithelial cells, main cause acute failure secondary IRI. MMP-2 MMP-9 are proteolytic enzymes involved in digesting proteins that components extracellular matrix (ECM) basement membrane nephrons. This way post-reperfusion MMP activation allows...
Arachidonic acid's (AA) metabolites, eicosanoids, exert a tremendous influence on circulatory and vascular homeostasis, in humans are generated by many organs cell types. In this study we wanted to verify whether platelets AA metabolism play significant role pathogenesis of essential hypertension (EH). Participants were divided into the (EH) control group. Plasma urine concentrations isoprostanes (8-iPF2α-III) thromboxane B2 (TxB2) determined using ELISA method. The levels 5-...
The outcome of kidney allograft transplantation is associated with numerous donor-dependent and recipient-dependent immunological non-immunological factors. Studies on genetic factors affecting the aspects, like ageing patient are still lacking. aim this study was analysis relative telomere length (RTL; T/S ratio) in biopsy specimens transplanted its correlation delayed graft function (DGF), acute rejection (AR) chronic dysfunction (CAD). enrolled 119 Caucasian recipients (64 M/55 F, mean...