A5029575790- Chromosomal and Genetic Variations
- Plant tissue culture and regeneration
- Plant Genetic and Mutation Studies
- Plant Molecular Biology Research
- Legume Nitrogen Fixing Symbiosis
- Botanical Research and Chemistry
- Plant nutrient uptake and metabolism
- Metabolism, Diabetes, and Cancer
- Biomedical Research and Pathophysiology
- Plant Reproductive Biology
- Agriculture, Plant Science, Crop Management
- Peroxisome Proliferator-Activated Receptors
- Marine and coastal plant biology
- Erythrocyte Function and Pathophysiology
- Botany and Plant Ecology Studies
- Garlic and Onion Studies
- Photosynthetic Processes and Mechanisms
- Plant Disease Resistance and Genetics
- Eicosanoids and Hypertension Pharmacology
- Organ Transplantation Techniques and Outcomes
- Metabolism and Genetic Disorders
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Antioxidant Activity and Oxidative Stress
- Algal biology and biofuel production
Pomeranian Medical University
2010-2024
University of Łódź
1992-2017
Czech Academy of Sciences, Institute of Physiology
1991
Université Libre de Bruxelles
1959-1961
Abstract Tumour necrosis factor alpha (TNF‐α) is implicated in post‐ischemic myocardial dysfunction. Two distinct TNF‐α receptors are shed from cell membranes and circulate plasma as soluble sTNFR1 sTNFR2 proteins. The aim of the study was to establish factors associated with concentrations its patients coronary artery disease (CAD). Since adenosine inhibits expression TNF‐α, two functional polymorphisms genes encoding enzymes participating metabolism, i.e. AMP deaminase‐1 ( AMPD1 , C34T)...
Arachidonic acid's (AA) metabolites, eicosanoids, exert a tremendous influence on circulatory and vascular homeostasis, in humans are generated by many organs cell types. In this study we wanted to verify whether platelets AA metabolism play significant role pathogenesis of essential hypertension (EH). Participants were divided into the (EH) control group. Plasma urine concentrations isoprostanes (8-iPF2α-III) thromboxane B2 (TxB2) determined using ELISA method. The levels 5-...
Inflammation plays a major role in the development and progression of atherosclerosis coronary artery disease (CAD). markers, including white blood cell (WBC) count, C-reactive protein (CRP) interleukin-6 (IL-6), are widely used for cardiovascular risk prediction. The aim study was to establish factors associated with WBC, CRP IL-6 patients CAD. Two functional polymorphisms genes encoding enzymes participating adenosine metabolism were analyzed (C34T AMPD1, G22A ADA).Plasma concentrations...
Patients were fully informed as to the study objectives and benefits, provided written consent prior enrolment. The protocol was approved by Committee on Human Research at Pomeranian Medical University, Szczecin, Poland. An intensification of free-radical reactions may contribute accelerated atherosclerosis in kidney graft recipients. We examined effect a Mediterranean-type diet (MD) oxidative status plasma erythrocytes Two patient groups formed: group consuming MD control with low-fat diet....
This study aimed at evaluating the concentration of erythrocyte purine nucleotides (ATP, ADP, AMP, IMP) in trained and sedentary subjects before after maximal physical exercise together with measuring activity metabolism enzymes as well (hypoxanthine, xanthine, uric acid) pyrimidine (uridine) degradation products blood. The included 15 male elite rowers [mean age 24.3 ± 2.56 years; oxygen uptake (VO2max) 52.8 4.54 mL/kg/min; endurance strength training 8.2 0.33 h per week for 6.4 2.52 years]...
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in females reproductive age. In women with PCOS, metabolic disorders such as insulin resistance (IR), hyperinsulinemia, obesity, diabetes mellitus, and other elements are likely to occur. Studies have shown an increase concentration activity oxidative stress (OS) markers patients compared that unaffected women. The aim this study was evaluate parameters OS PCOS their relation without menstrual a normal body weight....
Polycystic ovarian syndrome (PCOS) is one of the most common endocrinopathies in females reproductive age and may affect 5-14% women. In women with PCO syndrome, metabolic disorders such as insulin resistance, hyperinsulinemia, obesity, diabetes mellitus, other elements occur. Patients PCOS often have overweight especially abdominal which risk factors for developing atherosclerosis. The atherogenicity indicators AIP (atherogenic index plasma) Castelli's are used to assess Studies shown an...
Abstract Background Peptidyl-prolyl isomerase, NIMA-interacting 1 (PIN1) plays a significant role in the brain and is implicated numerous cellular processes related to Alzheimer's disease (AD) other neurodegenerative conditions. There are confounding results concerning PIN1 activity AD brains. Also genetic variation was inconsistently associated with risk. Methods We performed analysis of coding promoter regions early- late-onset frontotemporal dementia (FTD) patients comparison healthy...
This study investigates potential associations between CD36 gene variants and the presence of risk factors in Caucasians with coronary artery disease (CAD) manifested at a young age. The group consisted 90 patients; men were ≤ 50 years old women 55 old. Amplicons exons 4 5 including fragments introns analyzed by DHPLC. Two polymorphisms found: IVS3-6 T/C (rs3173798) IVS4-10 G/A (rs3211892). C allele polymorphism was associated higher prevalence obesity diabetes, hsCRP, lower Lp(a) serum...
Apart from their main role in transporting oxygen and carbon dioxide, erythrocytes play also an important organism antioxidative defence. Direct exposure to reactive species (ROS) results shortening of half-life, even by 50%. The presence glucose, being the substrate pentose phosphate pathway (PPP) cycle, is one factors that can have influence on level oxidative stress. activity PPP increases during Glucose guarantees normal functioning with production reductive equivalents amounts necessary...
Lipoxygenases are a family of non-heme enzyme dioxygenases. The role lipoxygenases is synthesis hydroperoxides fatty acids, which perform signaling functions in the body. Studies on conjugated linoleic acids (CLAs) as with potential anti-atherosclerotic function have recently been initiated. aim study was to test effect CLAs and acid 5- 15-lipoxygenase (5-LO, 15-LO-1) activity, their mRNA expression, concentration cells. It also desired determine whether substrates for enzymes. For...
Objective. The common C34T polymorphism in the AMP deaminase‐1 (AMPD1) gene results an inactive enzyme homozygotes for mutated T allele. Some studies have shown association of allele with longer survival heart failure (HF) and/or coronary artery disease (CAD). aim this study was to assess genotype–phenotype correlations such patients, emphasis on components metabolic syndrome. Methods. Ninety‐seven patients CAD without HF (CAD+ HF–) and 104 (HF+) were genotyped by PCR‐RFLP. genetic control...