A5026987359- Peroxisome Proliferator-Activated Receptors
- Fluoride Effects and Removal
- Cardiovascular Disease and Adiposity
- Cardiac Imaging and Diagnostics
- Lipoproteins and Cardiovascular Health
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Cardiovascular Function and Risk Factors
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Mercury impact and mitigation studies
- Cancer, Lipids, and Metabolism
- Vascular Malformations Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Bone and Dental Protein Studies
- RNA modifications and cancer
- Diabetes and associated disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Vitamin C and Antioxidants Research
- Adipose Tissue and Metabolism
- Angiogenesis and VEGF in Cancer
- Fatty Acid Research and Health
- Computational Drug Discovery Methods
- Cardiac Ischemia and Reperfusion
- Physiological and biochemical adaptations
Pomeranian Medical University
2013-2024
University of Szczecin
2007
CD36 is a transmembrane glycoprotein of the class B scavenger receptor family. The gene located on chromosome 7 q11.2 and encoded by 15 exons. Defective likely candidate for impaired fatty acid metabolism, glucose intolerance, atherosclerosis, arterial hypertension, diabetes, cardiomyopathy, Alzheimer disease, modification clinical course malaria. Contradictory data concerning effects antiatherosclerotic drugs expression indicate that further investigation role in development atherosclerosis...
Background: The pathogenesis of atherosclerosis is multifactorial and diverse. Pro-inflammatory cytokines are involved in these processes. It suggested that inflammation may represent a novel modifiable risk factor for cardiovascular disease. Therefore, this study aimed to gain insight into the relationship between plasma concentrations TNF, VEGF, IL-6, radiological parameters progression patients with early-onset coronary artery disease (CAD). Methods: Seventy clinically stable were...
Introduction: Childhood obesity has been associated with the development of insulin resistance, potentially leading to several metabolic disorders. Osteocalcin reported contribute regulation glucose tolerance and sensitivity. The purpose this study was examine relationship between serum osteocalcin risk factors in obese children adolescents. Material methods: Age, gender, pubertal stage, adiposity markers (standard deviation score body mass index: BMI-SDS, percentage fat, waist...
Arachidonic acid's (AA) metabolites, eicosanoids, exert a tremendous influence on circulatory and vascular homeostasis, in humans are generated by many organs cell types. In this study we wanted to verify whether platelets AA metabolism play significant role pathogenesis of essential hypertension (EH). Participants were divided into the (EH) control group. Plasma urine concentrations isoprostanes (8-iPF2α-III) thromboxane B2 (TxB2) determined using ELISA method. The levels 5-...
Introduction: Tumor necrosis factor (TNF), a pro-inflammatory cytokine, can be produced by cardiomyocytes, leading to metabolic disorders in the myocardium. The objective of this study was assess relationship between plasma levels TNF cytokine and presence known biochemical clinical risk factors for cardiovascular disease, along with parameters cardiac morphology patients diagnosed coronary artery disease (CAD) at young age. Materials Methods: group included 75 men aged up 50 years 25 women...
Flow-diverting stents can help treat complex and wide-necked cerebral aneurysms. The aim of the study was to evaluate initial experiences related safety effectiveness eight aneurysms treated with a new dual layer coverage designed flow-diverter device. In 2012 Fred devices were used 8 unruptured wide neck (dome-neck ratio ≤ 1.5) sidewall in 6 patients. All located anterior circulation on internal carotid artery (ICA). 4 larger (> 10 mm) one 3D coil association reduce potential incidence...
This is the first study to investigate relationship between plasma concentration of soluble CD36 (sCD36) and gene polymorphisms as well clinical echocardiographic parameters in patients with early onset coronary artery disease (CAD).sCD36 concentrations were measured by ELISA kits. sequence alterations detected DHPLC technique comprised single nucleotide substitutions: rs3173798, rs3211892, rs5956 rs141680676.There significant negative correlations sCD36 red blood cell count, hemoglobin,...
This study investigates potential associations between CD36 gene variants and the presence of risk factors in Caucasians with coronary artery disease (CAD) manifested at a young age. The group consisted 90 patients; men were ≤ 50 years old women 55 old. Amplicons exons 4 5 including fragments introns analyzed by DHPLC. Two polymorphisms found: IVS3-6 T/C (rs3173798) IVS4-10 G/A (rs3211892). C allele polymorphism was associated higher prevalence obesity diabetes, hsCRP, lower Lp(a) serum...
Over the last two decades, many studies have investigated association between interleukin 6 (IL-6) and pathogenesis progression of coronary artery disease (CAD). Patients with CAD manifested at a young age are particularly interesting group. They differ from older patients, not only in terms severity atherosclerosis, but also risk factor profiles, short- long-term prognosis after myocardial infarction (MI). The role IL-6 younger patients is less well-known. Therefore, our study aimed to...
The aim of the study was to determine role alcoholic drinks as a potential source dietary fluoride by means measuring levels in selected available on Polish market that are also diverse terms percentage content ethanol. conducted 48 types with low, medium, and high alcohol offered various manufacturers, both foreign. Fluoride concentrations individual samples were measured potentiometric method ion-selective electrode. highest determined lowest (less than 10 % v/v ethanol), observed (above...
Acute coronary syndrome occurs when the heart muscle does not receive adequate oxygen and nutrients in a timely manner. syndromes are primarily due to atherosclerosis of arteries, i.e., disease. Nitric oxide (NO) is synthesised from L-arginine endothelial cells by constitutive calcium-calmodulin-dependent enzyme, nitric synthase (NOS), which mediates endothelium-dependent vasodilatation. Endothelial (eNOS) predominantly expressed cells. Three NOS isoforms have been detected different tissue:...
The imbalanced network of adipokines may contribute to the development systemic low-grade inflammation, metabolic diseases and coronary artery disease (CAD). In last decade, three classic adipokines-adiponectin, leptin resistin-have been particular interest in studies patients with CAD due their numerous properties relation cardiovascular system. This has directed our attention association cardiac structure function heart failure (HF), a common end effect CAD. Thus, purpose this study was...
Denaturing high-performance liquid chromatography (DHPLC) has been employed as a prescreening tool to reduce the amount of DNA sequencing. It could be simple and cost-effective screening method for mutations polymorphisms in exons 4, 5, 6 CD36 gene, which encode protein region responsible removal oxidized low-density lipoprotein. Genomic was isolated from 306 Caucasian infants Polish origin. Six single-nucleotide substitutions were detected by DHPLC confirmed direct The A591T, G550A, C572T...
I In nt tr ro od du uc ct ti io on n: : CD36 plays an important role in long-chain fatty acid homeostasis skeletal muscle and the myocardium.CD36 deficiency may lead to reduced myocardial uptake of acid.Therefore, different mutations gene contribute clinical heterogeneity cardiac hypertrophy.M Ma at te er ri ia al l a nd d m me et th ho ds s: The objective study was investigate whether there is association between sequence changes echocardiographic electrocardiographic parameters Caucasian...