A5028401124- Adenosine and Purinergic Signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Cardiac Imaging and Diagnostics
- Vagus Nerve Stimulation Research
- Pregnancy and Medication Impact
- Biomarkers in Disease Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Cardiac Ischemia and Reperfusion
- Renal Transplantation Outcomes and Treatments
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Neurological Complications and Syndromes
- Pharmacogenetics and Drug Metabolism
- Renal Diseases and Glomerulopathies
- Cardiac Arrest and Resuscitation
- Prenatal Substance Exposure Effects
- Inflammatory mediators and NSAID effects
- Diabetes and associated disorders
- Acute Myocardial Infarction Research
- Blood properties and coagulation
- Peroxisome Proliferator-Activated Receptors
- Cardiac Arrhythmias and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Psychedelics and Drug Studies
Pomeranian Medical University
2014-2021
Over the last two decades, many studies have investigated association between interleukin 6 (IL-6) and pathogenesis progression of coronary artery disease (CAD). Patients with CAD manifested at a young age are particularly interesting group. They differ from older patients, not only in terms severity atherosclerosis, but also risk factor profiles, short- long-term prognosis after myocardial infarction (MI). The role IL-6 younger patients is less well-known. Therefore, our study aimed to...
A new approach to improve the effectiveness of acute myeloid leukemia (AML) treatment is use properties purinergic signaling molecules secreted into bone marrow milieu in response leukemic cell growth. Therefore, our study aimed evaluate effects extracellular adenine nucleotides and adenosine on growth death parameters THP-1 line. Cells were exposed ATP, ADP, AMP, nonhydrolyzable analogues ATP ADP (ATPγS ADPβS) a 1–1000 μM broad concentration range. The basal mRNA expression P1 P2 receptors...
The imbalanced network of adipokines may contribute to the development systemic low-grade inflammation, metabolic diseases and coronary artery disease (CAD). In last decade, three classic adipokines-adiponectin, leptin resistin-have been particular interest in studies patients with CAD due their numerous properties relation cardiovascular system. This has directed our attention association cardiac structure function heart failure (HF), a common end effect CAD. Thus, purpose this study was...
Tom 74
Abstract For many years, researchers have studied the cardioprotective properties of adenosine and attempted to use compound in treatment myocardial infarction. Adenosine exhibits other effects, as well, which can be helpful treating complications Over last decade, results over a dozen studies conducted on animal models evaluating possibility using receptor agonists antagonists prevention chronic heart failure arrhythmias after infarction been published. This is particularly important view...
Abstract Adenosine is an endogenous compound with cardioprotective properties that acts via A 1 , 2A 2B and 3 plasma membrane receptors. Over the last several decades, mechanisms underlying adenosine’s protective effects in ischemic myocardium were investigated. They are basis for preconditioning postconditioning procedures protect heart from ischemia/reperfusion injury. The promising results of animal model studies have encouraged a large group researchers to conduct clinical trials...