A5032316718- Fluoride Effects and Removal
- Musculoskeletal pain and rehabilitation
- Neurotransmitter Receptor Influence on Behavior
- Mercury impact and mitigation studies
- Cannabis and Cannabinoid Research
- Pain Mechanisms and Treatments
- Pain Management and Opioid Use
- Geology and Environmental Impact Studies
- Nutrition and Health Studies
- Drug-Induced Hepatotoxicity and Protection
- Opioid Use Disorder Treatment
- Prenatal Substance Exposure Effects
- Bone and Dental Protein Studies
- Psychedelics and Drug Studies
- Poisoning and overdose treatments
- Spine and Intervertebral Disc Pathology
- Metabolomics and Mass Spectrometry Studies
- Psoriasis: Treatment and Pathogenesis
- Inflammatory mediators and NSAID effects
- Bone health and treatments
- Myofascial pain diagnosis and treatment
- Dental Radiography and Imaging
- Sustainable Development and Environmental Management
- Anesthesia and Pain Management
- Alkaline Phosphatase Research Studies
Pomeranian Medical University
2016-2025
New York Academy of Medicine
2001-2006
Szczecin Academy of Arts
2002
University of Szczecin
1995
Instytut Farmaceutyczny
1990
Total hip and knee replacements are the most common orthopedic procedures performed due to osteoarthritis. Pain is an intrinsic symptom accompanying osteoarthritis, persisting long before surgery, continuing during preoperative postoperative periods. Appropriate pain management after surgery determines comfort, duration, cost of hospitalization, as well effectiveness rehabilitation. Individual differences in perception tolerance patients remain important research topic. Therefore, aim this...
This study was aimed at the evaluation of relationship between genetic polymorphisms catechol-O-methyltransferase (COMT) (rs4680:A > G-Val158Met, rs6269:A G, rs4633:C T, rs4818:C G) and pain sensitivity after lumbar discectomy.All patients had one-level symptomatic disc herniation from L3 to S1. The primary data recorded included visual analogue scales assessing back leg pain, Oswestry Disability Questionnaire quality life intensity, received/filled pre- postoperatively. Each subject...
Cytokines are small and membrane-bound protein-based cell signaling molecules that aid cell-to-cell communication in physiological pathological processes. TNF-α is a pleiotropic cytokine, it regarded as principal cytokine the acute chronic phases of immune inflammatory response. has been demonstrated to play role neuroplasticity myelination, well excitotoxicity, neuroinflammation, damage blood-brain barrier. The involvement etiology Parkinson’s disease, both its early late stages,...
Background/Objectives: This study aimed to evaluate the degradation of omeprazole suspension under various pH conditions and propose recommendations for preparing compounded suspensions. Given clinical need alternative dosage forms pediatric geriatric patients those with dysphagia, research focused on assessing whether modifications in formulation composition—specifically inclusion sodium bicarbonate—could improve stability, thus enhancing its bioavailability. Methods: Three formulations...
Background: Diclofenac is a phenylacetic acid derivative classified as non-selective COX inhibitor. Similar to other NSAIDs, it characterized by anti-inflammatory, antipyretic, and analgesic effects. Long-term therapy with diclofenac might also lead severe gastrointestinal, renal, or cardiovascular systems disorders. Aim of the study was compare own formulation prepared from pharmaceutical raw materials ready-to-use product. Methods: In in vitro permeation experiments, human skin excised...
Recent studies have revealed the pivotal role of Th17 cells and interleukin-17 (IL-17) in plaque psoriasis development treatment outcome. The IL-17 family consists 6 structurally related cytokines (IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, IL-17F), which IL-17A IL-17F mediate similar biological effects.The aim this study was to evaluate an association between IL17A (-197G>A; rs2275913) IL17F (rs763780: T>C; rs11465553: G>A; rs2397084: T>C) polymorphisms with susceptibility as well response...
Pain is one of the most interdisciplinary clinical symptoms a disease. The aim study was to evaluate association COMT gene polymorphism with pain perception in patients after total hip replacement (THR). included 195 qualified for surgical treatment (THR) due osteoarthritis. Patients previously undergoing subsequently underwent multimodal management therapy, accordance recommendations treating postoperative pain. intensity measured three times at pre-defined time intervals: 1.5, 6 and 12...
In the treatment of pain, especially chronic rule multimodal therapy applies, based on various painkillers mechanisms action. The aim conducted study was to evaluate in vitro penetration ketoprofen (KET) and lidocaine hydrochloride (LH) through human skin from a vehicle with transdermal properties. results obtained use Franz chamber showed statistically significantly higher KET as compared commercial preparations. It also shown that addition LH did not change amount permeated. by adding...
Limited studies indicate a possible association of 5′-UTR thymidylate synthase enhancer region polymorphism and treatment outcome in patients medicated with 5-fluorouracil (5-FU). The study was designed to verify the relationship colorectal cancer (CRC), Polish population that received 5-FU-based adjuvant chemotherapy. analyzed 145 Astler-Coller B2 C CRC patients. Genotyping for variable number tandem repeats G single-nucleotide (TS) gene carried out. TS genotypes were classified into high...
Lumbar intervertebral disk herniation (LDH) is considered one of the major risk factors for lower back pain, mainly caused by irritation a spinal nerve or its root. One genes related to pain perception SCN9A, which encodes voltage gated sodium channel NaV1.7, key molecule involved in peripheral processing. It had been presented before that common polymorphism within SCN9A (rs6746030: G > A, R1150W) might influence nociception general population. Hence, present study was aimed at...
The COL1A1 and COL5A1 variants have been associated with the risk of musculoskeletal injuries. Therefore, main aim study was to investigate association between three polymorphisms within two genes (rs1800012 in COL1A1, as well rs12722 rs13946 COL5A1) reported, yet rarely described literature, injuries joint muscle area a physically active Caucasian population. Polish students (n = 114) were recruited divided into following groups: 53) without 61) injures. Genotyping carried out using...
In recent years, increasing attention has been paid to the contribution of genetic factors variability in patient pain threshold and efficacy management. One genes implicated pathology treatment response is interleukin 6 (IL6). The aim present study was evaluate association between IL6 (rs1800795: –174G>C) opioid requirements patients after total hip replacement (THR). A 196 eligible for (126 women, 70 men) were subjected THR. THR procedure performed using spinal anaesthesia implementing...
Each year approximately 1 million total hip replacements are performed worldwide. The most common indications to choose this procedure rest pain and after activity as well functional limitations influencing daily activities. Experimental is highly variable by individuals, which partly due genetics. aim of the study was investigate a possible association catechol-O-methyltransferase (COMT) μ-opioid receptor (OPRM1) genotypes with perception in patients undergoing replacement knee taking into...
The etiology of drug addiction, a central nervous system (CNS) disease, is not fully known. This complex problem believed to be connected with concurrently affecting genetic, psychological and environmental factors. development addiction CNS reinforcement dopaminergic neurotransmission. Molecular processes are postulated universal character allow presume similar mechanism dependence for both ethanol other substances. Therefore, elements transmission become excellent candidates the...
The aim of the present in vitro study was to investigate effects 10% and 40% citric acid (CA) on color calcium silicate–based cements (CSCs) comparison common root canal irrigants. Samples six CSCs (n = 6)—ProRoot MTA (Dentsply, Tulsa, OK, USA), Biodentine (Septodont, Saint-Maur-des-Fossés, France), Plus (Avalon Biomed Inc, by Prevest Denpro Limited, Jammu, India), Repair HP (Angelus, Londrina, PR, Brazil), Ortho (BioMTA, Seoul, Korea), Retro Korea)—were immersed CA as well 15% EDTA, 2%...
The purpose of this study was to investigate whether regular physical activity can alter the pressure pain threshold, tolerance, and subjective perception in individuals who have experienced a cardiovascular event. involved 85 aged 37 84 years (M = 65.36) qualified for outpatient cardiac rehabilitation, which consisted 24 training sessions. patients were all tested twice: on first last day rehabilitation program. Assessments threshold tolerance performed with an algometer. To assess coping...