A5002251157- Fluoride Effects and Removal
- Cancer Immunotherapy and Biomarkers
- Peroxisome Proliferator-Activated Receptors
- Inflammatory Biomarkers in Disease Prognosis
- Organ Transplantation Techniques and Outcomes
- Osteomyelitis and Bone Disorders Research
- Eicosanoids and Hypertension Pharmacology
- Adenosine and Purinergic Signaling
- Renal Transplantation Outcomes and Treatments
- Vitamin C and Antioxidants Research
- Immune cells in cancer
- Dental materials and restorations
- Antioxidant Activity and Oxidative Stress
- Mercury impact and mitigation studies
- Heavy Metal Exposure and Toxicity
- Exercise and Physiological Responses
- Inflammatory Bowel Disease
- Dermatological and Skeletal Disorders
- Gastrointestinal Tumor Research and Treatment
- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Alzheimer's disease research and treatments
- Systemic Sclerosis and Related Diseases
- Bone and Dental Protein Studies
- Cardiac Ischemia and Reperfusion
Pomeranian Medical University
2011-2022
Centrum Onkologii
2022
Medical University of Białystok
2015-2020
Greater Poland Cancer Center
2020
Film Independent
2019
University of Siedlce
2015
Medical University of Lublin
2012
Colorectal cancer is the third most common malignancy worldwide. Therefore, it critically important to identify new useful markers that can be easily obtained in routine practice. Inflammation a crucial issue pathogenesis and development of cancer.
Abstract Tumour necrosis factor alpha (TNF‐α) is implicated in post‐ischemic myocardial dysfunction. Two distinct TNF‐α receptors are shed from cell membranes and circulate plasma as soluble sTNFR1 sTNFR2 proteins. The aim of the study was to establish factors associated with concentrations its patients coronary artery disease (CAD). Since adenosine inhibits expression TNF‐α, two functional polymorphisms genes encoding enzymes participating metabolism, i.e. AMP deaminase‐1 ( AMPD1 , C34T)...
Maximal physical exertion is accompanied by increased degradation of purine nucleotides in muscles with the products catabolism accumulating plasma. Thanks to membrane transporters, these remain an equilibrium between plasma and red blood cells where they may serve as substrates salvage reactions, contributing increase concentrations nucleotides. In this study, we measured adenine (ATP, ADP, AMP), inosine (IMP), guanine (GTP, GDP, GMP), also pyridine (NAD, NADP) immediately after...
BACKGROUND The aim of this study was to evaluate the elution BisGMA, UDMA, TEGDMA, and HEMA monomers from flowable bulk fill composite resins with different resin matrix compositions, polymerized in 4-mm-thick layers, into 3 media. MATERIAL AND METHODS Three bulk-fill (SDR® (SDR), X-tra base (XB) BEAUTIFIL-Bulk Flowable (BF)) resin-composites were tested. Cylindrical samples immersed 100% ethanol, 75% distilled water. concentrations measured using HLPC method (Agilent Technologies 1200...
<i>Background/Aims:</i> The common G22A polymorphism in the adenosine deaminase (ADA) gene leads to substitution Asp8Asn. lower activity of enzyme encoded by A22 (ADA*2) allele may increase tissue concentrations adenosine, a potent cardioprotective agent. In case-control study, we investigated association between ADA and coronary artery disease (CAD). <i>Methods:</i> A hundred seventy-one CAD patients from north-western part Poland 200 consecutive newborns same...
Arachidonic acid's (AA) metabolites, eicosanoids, exert a tremendous influence on circulatory and vascular homeostasis, in humans are generated by many organs cell types. In this study we wanted to verify whether platelets AA metabolism play significant role pathogenesis of essential hypertension (EH). Participants were divided into the (EH) control group. Plasma urine concentrations isoprostanes (8-iPF2α-III) thromboxane B2 (TxB2) determined using ELISA method. The levels 5-...
Inflammation plays a major role in the development and progression of atherosclerosis coronary artery disease (CAD). markers, including white blood cell (WBC) count, C-reactive protein (CRP) interleukin-6 (IL-6), are widely used for cardiovascular risk prediction. The aim study was to establish factors associated with WBC, CRP IL-6 patients CAD. Two functional polymorphisms genes encoding enzymes participating adenosine metabolism were analyzed (C34T AMPD1, G22A ADA).Plasma concentrations...
Patients were fully informed as to the study objectives and benefits, provided written consent prior enrolment. The protocol was approved by Committee on Human Research at Pomeranian Medical University, Szczecin, Poland. An intensification of free-radical reactions may contribute accelerated atherosclerosis in kidney graft recipients. We examined effect a Mediterranean-type diet (MD) oxidative status plasma erythrocytes Two patient groups formed: group consuming MD control with low-fat diet....
Germline mutations in the DNA mismatch repair genes MSH2 and MLH1 account for a significant proportion of hereditary non‐polyposis colorectal cancer (HNPCC) families. One approach by which development an efficient DNA‐testing procedure can be implemented is to describe nature frequency common particular ethnic groups. Two hundred twenty‐six patients from families matching Amsterdam II diagnostic criteria or suspected HNPCC were screened germline mutations. Fifty different pathogenic found,...
This study aimed at evaluating the concentration of erythrocyte purine nucleotides (ATP, ADP, AMP, IMP) in trained and sedentary subjects before after maximal physical exercise together with measuring activity metabolism enzymes as well (hypoxanthine, xanthine, uric acid) pyrimidine (uridine) degradation products blood. The included 15 male elite rowers [mean age 24.3 ± 2.56 years; oxygen uptake (VO2max) 52.8 4.54 mL/kg/min; endurance strength training 8.2 0.33 h per week for 6.4 2.52 years]...
This is the first study to investigate relationship between plasma concentration of soluble CD36 (sCD36) and gene polymorphisms as well clinical echocardiographic parameters in patients with early onset coronary artery disease (CAD).sCD36 concentrations were measured by ELISA kits. sequence alterations detected DHPLC technique comprised single nucleotide substitutions: rs3173798, rs3211892, rs5956 rs141680676.There significant negative correlations sCD36 red blood cell count, hemoglobin,...
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in females reproductive age. In women with PCOS, metabolic disorders such as insulin resistance (IR), hyperinsulinemia, obesity, diabetes mellitus, and other elements are likely to occur. Studies have shown an increase concentration activity oxidative stress (OS) markers patients compared that unaffected women. The aim this study was evaluate parameters OS PCOS their relation without menstrual a normal body weight....
Polycystic ovarian syndrome (PCOS) is one of the most common endocrinopathies in females reproductive age and may affect 5-14% women. In women with PCO syndrome, metabolic disorders such as insulin resistance, hyperinsulinemia, obesity, diabetes mellitus, other elements occur. Patients PCOS often have overweight especially abdominal which risk factors for developing atherosclerosis. The atherogenicity indicators AIP (atherogenic index plasma) Castelli's are used to assess Studies shown an...
Abstract Background Peptidyl-prolyl isomerase, NIMA-interacting 1 (PIN1) plays a significant role in the brain and is implicated numerous cellular processes related to Alzheimer's disease (AD) other neurodegenerative conditions. There are confounding results concerning PIN1 activity AD brains. Also genetic variation was inconsistently associated with risk. Methods We performed analysis of coding promoter regions early- late-onset frontotemporal dementia (FTD) patients comparison healthy...
This study investigates potential associations between CD36 gene variants and the presence of risk factors in Caucasians with coronary artery disease (CAD) manifested at a young age. The group consisted 90 patients; men were ≤ 50 years old women 55 old. Amplicons exons 4 5 including fragments introns analyzed by DHPLC. Two polymorphisms found: IVS3-6 T/C (rs3173798) IVS4-10 G/A (rs3211892). C allele polymorphism was associated higher prevalence obesity diabetes, hsCRP, lower Lp(a) serum...
Colorectal cancer (CRC) is one of the most common malignant cancers worldwide. Patients with CRC are diagnosed based on various predictors, including performance status, clinicopathological factors and TNM classification. The aim present study was to analyze neutrophil lymphocyte counts, as well neutrophil‑to‑lymphocyte ratio (NLR) in pre‑ postoperative blood samples patients correlation specific anatomical variables disease‑ free survival (DFS). count (preNEU postNEU, respectively), NLR...
Histopathological evaluation plays a key role in the diagnosis of colorectal cancer (CRC). Tumor-related local inflammation is regarded as novel prognostic parameter. Neutrophils constitute one main types inflammatory cells. The aim present study was to evaluate value intratumoral tumor-associated neutrophils (intraTANs), stromal TANs (stromaTANs) and necrosis, well their combined parametric formalin-fixed paraffin-embedded tissue sections from patients with CRC. For this purpose,...
Apart from their main role in transporting oxygen and carbon dioxide, erythrocytes play also an important organism antioxidative defence. Direct exposure to reactive species (ROS) results shortening of half-life, even by 50%. The presence glucose, being the substrate pentose phosphate pathway (PPP) cycle, is one factors that can have influence on level oxidative stress. activity PPP increases during Glucose guarantees normal functioning with production reductive equivalents amounts necessary...