A5019415821- Sarcoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Genomic variations and chromosomal abnormalities
- Gastrointestinal disorders and treatments
- Lipoproteins and Cardiovascular Health
- Genetic factors in colorectal cancer
- Ovarian cancer diagnosis and treatment
- Gastric Cancer Management and Outcomes
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Prenatal Screening and Diagnostics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Chromosomal and Genetic Variations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- Tumors and Oncological Cases
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Renal and related cancers
- Genetic Syndromes and Imprinting
- DNA and Nucleic Acid Chemistry
- Mast cells and histamine
- Mitochondrial Function and Pathology
Gdańsk Medical University
2014-2024
Polish Academy of Sciences
2018-2019
University Clinical Centre
2017
Washington Center
2015
University of Washington
2015
Pediatrics and Genetics
1994-2014
Medical University of Lublin
2013
University of Gdańsk
2005-2013
Jagiellonian University
2006-2009
KU Leuven
2006-2009
A translocation that involves chromosome X (band p11.2) and 18 q11.2) was observed in short-term vitro cultures of cells from five synovial sarcomas one malignant fibrous histiocytoma. In four these tumors, the t(X;18)(p11.2;q11.2) reciprocal. The two other tumors had complex translocations: t(X;18;21)(p11.2;q11.2;p13) t(X;15;18)(p11.2;q23;q11.2). between chromosomes not detected histological types soft tissue sarcoma. X;18 rearrangement appears to characterize sarcoma is first description a...
Abstract Purpose: Although the mutational status in gastrointestinal stromal tumors (GIST) can predict response to treatment with tyrosine kinase inhibitors, role of tumor genotype as a prognostic factor remains controversial. The ConticaGIST study sought determine pathologic and molecular factors associated disease-free survival (DFS) patients operable, imatinib-naive GIST. Experimental Design: Clinicopathologic data from 1,056 localized GIST who underwent surgery curative intention (R0/R1)...
Abstract Cytogenetic analysis after short‐term culture in vitro of primary tumor samples was attempted 82 patients with prostatic cancer. Tumor material obtained by radical prostatectomy or transurethral resection. Successful cytogenetic studies were performed on 57 tumors which five well, 30 moderately, and 22 poorly differentiated adenocarcinomas. Only normal karyotypes found 24 tumors. Structural nonclonal aberrations detected 18 clonal karyotypic abnormalities 15 The most common...
Synovial sarcoma (SS) is a mesenchymal neoplasm that typically shows epithelial differentiation. SS commonly metastasizes to lung and pleura, has also been reported as the primary in these locations. The histologic distinction of from mesothelioma may be difficult because combination epithelioid spindle cells, potentially shared locations, antigenic expression. In this study authors examined 103 well-documented SSs including 41 biphasic, 44 monophasic, 18 poorly differentiated comparison...
Abstract Clear cell sarcoma (CCS) is a rare malignant soft tissue tumor particularly associated with tendons and aponeuroses. The cytogenetic hallmark the translocation t(12;22)(q13;q12) resulting in chimeric EWS/ATF1 gene which 3′‐terminal part of EWS at 22q replaced by ATF1 12q. To date, only 13 cases CCS have been analyzed for fusion genes transcription level, there no information about breakpoints genomic level. In present study, we describe molecular genetic characteristics from 10...
Numerical chromosome aberrations are common in several types of malignant tumors. Recently, trisomy 7 and loss the Y were described cultures from nonneoplastic tissue, making significance these as cancer-associated changes doubtful. We herein report mosaic occurrence four consecutive short-term initiated normal kidney tissue. Smaller clones with 10 present three cases, only culture established a male also showed chromosome.
We have analyzed several cases of Beckwith–Wiedemann syndrome (BWS) with Wilms' tumor in a familial setting, which give insight into the complex controls imprinting and gene expression chromosome 11p15 region. describe 2.2-kbp microdeletion H19 /insulin-like growth factor 2 ( IGF2 )-imprinting center eliminating three target sites chromatin insulator protein CTCF that we believe here is necessary, but not sufficient, to cause BWS tumor. Maternal inheritance deletion associated loss...
Abstract Gastrointestinal stromal tumors (GISTs) comprise a biologically diverse group of neoplasms with respect to activating mutations in either KIT or PDGFRA , histology, anatomical site origin, and clinical aggressiveness. In this study, we applied the high resolution array‐based comparative genomic hybridization (array‐CGH) technology 66 primary GISTs (40 gastric 26 nongastric, 48 18 mutations) for identification novel high‐level alterations characterization genotype‐related changes....
We investigated the status of estrogen receptor alpha (ERα), progesterone (PR), and epidermal growth factor 2 (HER2) in primary tumor corresponding brain metastases a consecutive series breast cancer patients. Additionally, we studied factors potentially influencing conversion evaluated its association with survival.The study group included 120 ERα, PR, HER2 tumors matched was determined centrally by immunohistochemistry and/or fluorescence situ hybridization.Using Allred score ≥ 3 as...
Abstract Synovial sarcoma is an aggressive soft‐tissue tumor that accounts for up to 10% of sarcomas. Cytogenetically, synovial characterized by the t(X;18)(p11;q11), found in more than 95% tumors. This translocation results rearrangements SYT gene 18q11 and one SSX1, SSX2, or SSX4 genes Xp11, creating a SYT/SSX1, SYT/SSX2, SYT/SSX4 chimeric gene. It has been shown patients with SYT/SSX1 fusion have shorter metastasis‐free survival do SYT/SSX2 . Previous studies also suggested clonal...
Abstract Various growth media and procedures for tissue disaggregation culturing were tested with regard to cell attachment, the type of cells grow out, emergence cytogenetically abnormal clones in cultures 20 primary breast carcinomas. Clonal chromosome abnormalities detected 16 cases (80%). Our findings allow us suggest a series modifications existing preparation techniques cancer cytogenetic analysis. The improvements include: (1) combined mechanical enzymatic tumor samples, (2)...
Currently available data on the relationship between prevalence of isolated congenital malformations and parental age are inconsistent frequently divergent. We utilised from Polish Registry Congenital Malformations (PRCM) to accurately assess interplay maternal paternal in risk non-syndromic malformations. Out 902 452 livebirths we studied 8683 children aged 0-2 years registered PRCM. Logistic regression was used simultaneously adjust estimates for age. Our indicated that were independently...
Gastrointestinal stromal tumors (GIST) mutational status is recognized factor related to the results of tyrosine kinase inhibitors therapy such as imatinib (IM) or sunitinib (SU). Arterial hypertension (AH) common adverse event SU, reported predictive in renal cell carcinoma. The aim study was analyze outcomes and factors predicting SU inoperable/metastatic CD117(+) GIST patients after IM failure. We identified 137 consecutive with advanced treated one center (2nd line treatment). Median...
Abstract Clonal chromosome aberrations were detected in 8 short‐term cultured malignant peripheral nerve sheath tumors (MPNST). Seven had a near‐triploid number and I was the hyperhaploid‐hypodiploid range. No recurrent structural rearrangements found; bands most frequently involved (3 tumors) 7p11, 12p13 14q11. The common numerical changes loss of sex (all at least 1 copy chromosomes 8, 16 22 (4 tumors). Pooling our data with those on 20 previously published MPNST abnormal karyotypes, we...