A5065262675- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Genomic variations and chromosomal abnormalities
- Cancer Genomics and Diagnostics
- Tumors and Oncological Cases
- Genomics and Chromatin Dynamics
- Oral and Maxillofacial Pathology
- Soft tissue tumor case studies
- Neurofibromatosis and Schwannoma Cases
- Vascular Tumors and Angiosarcomas
- Musculoskeletal synovial abnormalities and treatments
- Lymphoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Cancer-related molecular mechanisms research
- Neuroblastoma Research and Treatments
- Histiocytic Disorders and Treatments
- Cancer and Skin Lesions
- Acute Myeloid Leukemia Research
- Medical Imaging and Pathology Studies
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Protein Degradation and Inhibitors
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- RNA modifications and cancer
Lund University
2015-2024
Scandinavian Sarcoma Group (Sweden)
2024
Skåne University Hospital
2012-2023
John Wiley & Sons (United States)
2019
The University of Texas MD Anderson Cancer Center
2018
Lund Science (Sweden)
2018
Duke Medical Center
2014
University of Oslo
2003-2014
Oslo University Hospital
2010-2014
Istituto Ortopedico Rizzoli
2011-2014
Malignant cells, like all actively growing must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been discovered. In particular, mutations of the binding proteins alpha thalassemia/mental retardation syndrome X-linked ( ATRX ) or death-domain associated protein DAXX shown to underlie a mechanism not involving telomerase (alternative lengthening telomeres), and point promoter reverse transcriptase TERT gene increase expression...
BACKGROUND: Malignant cells must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been discovered. In particular, mutations of the binding proteins alpha thalassemia/mental retardation syndrome X-linked (ATRX) or death-domain associated protein (DAXX) shown to underlie a mechanism not involving telomerase (alternative lengthening telomeres), and point promoter reverse transcriptase (TERT) gene increase expression occur...
It has long been known that rearrangements of chromosomes through breakage-fusion-bridge (BFB) cycles may cause variability phenotypic and genetic traits within a cell population. Because intercellular heterogeneity is often found in neoplastic tissues, we investigated the occurrence BFB events human solid tumors. Evidence frequent was malignancies showed unspecific chromosome aberrations, including ring chromosomes, dicentric telomeric associations, as well extensive intratumor pattern...
High-grade osteosarcoma is a malignant primary bone tumor with peak incidence in adolescence. Overall survival (OS) of patients resectable metastatic disease approximately 20%. The exact mechanisms development metastases remain unclear. Most studies focus on cells, but it increasingly evident that stroma plays an important role tumorigenesis and metastasis. We investigated the metastasis by studying cells their stromal context.To identify gene signatures playing metastasis, we carried out...
Although mechanisms for chromosomal instability in tumors have been described animal and vitro models, little is known about these processes man. To explore cytogenetic evolution human tumors, breakpoint profiles were constructed 102 pancreatic carcinomas 140 osteosarcomas, two tumor types characterized by extensive genomic instability. Cases with few alterations showed a preferential clustering of breakpoints to the terminal bands, whereas many changes primarily interstitial centromeric...
Low-grade fibromyxoid sarcoma (LGFMS) is a distinctive fibroblastic neoplasm that characterized by alternating collagenous and myxoid areas, deceptively bland spindle cell morphology, whorling architecture, t(7;16) translocation involving FUS CREB3L2. Owing to variable morphology lack of discriminatory markers, LGFMS can be difficult distinguish from benign mesenchymal tumors other low-grade sarcomas. Gene expression profiling has identified differential upregulation the mucin 4 (MUC4) gene...
Cancer gene fusions that encode a chimeric protein are often characterized by an intragenic discontinuity in the RNA\expression levels of exons 5' or 3' to fusion point one both partners due differences activation their respective promoters. Based on this, we developed unbiased, genome-wide bioinformatic screen for using Affymetrix Exon array expression data. Using training set 46 samples with different known fusions, data analysis pipeline, "Fusion Score (FS) model", score and rank genes...
Abstract Gains and losses of DNA are prevalent in cancer emerge as a consequence inter-related processes replication stress, mitotic errors, spindle multipolarity breakage–fusion–bridge cycles, among others, which may lead to chromosomal instability aneuploidy 1,2 . These copy number alterations contribute initiation, progression therapeutic resistance 3–5 Here we present conceptual framework examine the patterns human that is widely applicable diverse data types, including whole-genome...
Solitary fibrous tumor (SFT) is a mesenchymal neoplasm displaying variable morphologic and clinical features. To identify pathogenetically important genetic rearrangements, 44 SFTs were analyzed using variety of techniques. Chromosome banding fluorescence in situ hybridization (FISH) showed recurrent breakpoints 12q13, clustering near the NAB2 STAT6 genes, single nucleotide polymorphism array analysis disclosed frequent deletions affecting . Quantitative real‐time PCR revealed high...
Sclerosing epithelioid fibrosarcoma (SEF) is a rare aggressive fibroblastic neoplasm composed of cords cells embedded in dense collagenous stroma. The reported immunophenotype SEF nonspecific. Some cases show morphologic and molecular overlap with low-grade fibromyxoid sarcoma (LGFMS), suggesting relationship between these tumor types. MUC4 has recently been identified as sensitive specific marker for LGFMS; expression was also observed 2 tumors hybrid features LGFMS. We investigated other...
Low-grade fibromyxoid sarcoma (LGFMS) is an indolent, late-metastasizing malignant soft-tissue tumor that often mistaken for either more benign or types. Cytogenetic analyses have identified a recurrent balanced translocation t(7;16) (q32-34;p11), later shown by molecular genetic approaches to result in FUS/CREB3L2 fusion gene. Whereas preliminary studies suggest this gene rearrangement specific LGFMS, its incidence type and the possible existence of variant genes not yet been addressed. For...