A5049319583- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Lymphoma Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
University College London
2021-2022
Abstract Gains and losses of DNA are prevalent in cancer emerge as a consequence inter-related processes replication stress, mitotic errors, spindle multipolarity breakage–fusion–bridge cycles, among others, which may lead to chromosomal instability aneuploidy 1,2 . These copy number alterations contribute initiation, progression therapeutic resistance 3–5 Here we present conceptual framework examine the patterns human that is widely applicable diverse data types, including whole-genome...
Central conventional chondrosarcoma (CS) is the most common subtype of primary malignant bone tumour in adults. Treatment options are usually limited to surgery, and prognosis challenging. These tumours characterised by presence absence IDH1 IDH2 mutations, recently, TERT promoter alterations have been reported around 20% cases. The effect these mutations on clinical outcome remains unclear. purpose this study was determine if prognostic accuracy can be improved addition genomic data,...
ABSTRACT The gains and losses of DNA that emerge as a consequence mitotic errors chromosomal instability are prevalent in cancer. These copy number alterations contribute to cancer initiaition, progression therapeutic resistance. Here, we present conceptual framework for examining the patterns human using whole-genome sequencing, whole-exome SNP6 microarray data making it widely applicable diverse datasets. Deploying this 9,873 cancers representing 33 types from TCGA project revealed set 19...
The treatment options for central chondrosarcoma are limited, and prognoses generally unreliable. presence absence of mutations in IDH1 , IDH2 defining events, TERT have been recently associated with poor outcome. Despite this, molecular biomarkers lacking. Here, analysing data from 356 patients, comprising results whole genome sequencing (n=68), digital droplet PCR (n=346), methylation arrays (n=57), we present a comprehensive genetic analysis suggest its clinical utility. Methylation...