A5084162980- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Cardiac tumors and thrombi
- Soft tissue tumor case studies
- Bone Tumor Diagnosis and Treatments
- Urologic and reproductive health conditions
- Oral and Maxillofacial Pathology
- Soft tissue tumors and treatment
- Neurofibromatosis and Schwannoma Cases
- Cancer Genomics and Diagnostics
- Ovarian cancer diagnosis and treatment
- Testicular diseases and treatments
- Tumors and Oncological Cases
- Gastrointestinal Tumor Research and Treatment
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Lymphoma Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Histiocytic Disorders and Treatments
- Cancer Diagnosis and Treatment
- Cancer and Skin Lesions
- Neuroblastoma Research and Treatments
- Renal and related cancers
- Prostate Cancer Diagnosis and Treatment
University Hospitals Birmingham NHS Foundation Trust
2019-2024
Institute of Cancer Research
2005-2024
Royal Marsden Hospital
2012-2023
Royal Marsden NHS Foundation Trust
2013-2023
Cancer Research UK Cambridge Center
2022
Royal Orthopaedic Hospital
2010-2021
University of Birmingham
2010-2021
Great Ormond Street Hospital for Children NHS Foundation Trust
2020
National Health Service
2000-2018
Memorial Sloan Kettering Cancer Center
2018
Human herpesvirus 8 (HHV-8, also called KSHV) is linked to the etiopathogenesis of Kaposi’s sarcoma (KS), multicentric Castleman’s disease (MCD), and primary effusion lymphoma (PEL). The universal presence HHV-8 in early KS has not yet been shown. We used a mAb (LN53) against latent nuclear antigen-1 (LNA-1) encoded by ORF73 study distribution cell types latently infected patch, plaque, nodular KS, MCD, PEL. In present <10% cells forming walls ectatic vessels. surrounding slit-like...
To investigate and describe the anatomic distribution, imaging features, pattern of metastatic spread malignant gastrointestinal stromal tumors (GISTs).The medical records all patients at our institution with a histologic diagnosis GIST were reviewed. Two radiologists knowledge reviewed radiologic findings by means consensus. Sixty-seven underwent computed tomography, scans primary tumor available in 38 patients.One hundred sixteen GISTs identified (76 men 40 women; mean age, 54.6 years +/-...
Adipocytic tumors are the most common type of soft tissue neoplasms. Distinguishing atypical lipomatous tumor-well-differentiated liposarcoma (WDL) from benign adipocytic neoplasms and dedifferentiated (DDL) pleomorphic or myxoid (LPS) can be difficult. WDL DDL characteristically harbor amplifications MDM2 CDK4 cell cycle oncogenes with protein overexpression also overexpress regulator p16. We assessed utility immunohistochemistry for CDK4, MDM2, p16 in routine histopathologic diagnosis...
PURPOSE: Synovial sarcoma (SS) is a common soft tissue (STS) with propensity for young adults and notable sensitivity to chemotherapy (CT). This study provides current clinicopathologic, staging, prognostic assessment SS. The problems the American Joint Committee Cancer (AJCC) Staging System in relation SS are discussed. METHODS: Review of prospective database supplemented by retrospective data. RESULTS: One hundred fifty patients were assessed; median age was 30 years follow-up 52 months....
Aggressive angiomyxoma of pelvic soft parts is a rare lesion with high risk recurrence. We report 10 cases angiomyofibroblastoma, hitherto uncharacterized benign tumor the vulva histologically mimicking aggressive angiomyxoma. All patients had vulval mass, often clinically diagnosed as Bartholin's cyst. There was no recurrence after excision. The tumors were well circumscribed, measuring 0.5–12 cm in maximum dimension. They characterised by alternating hypercellular and hypocellular...
Deep fibromatoses (desmoid tumors) are clonal myofibroblastic proliferations that prone to aggressive local recurrences but do not metastasize. They must be distinguished from a host of fibroblastic and lesions as well smooth muscle neoplasms. Virtually all deep have somatic beta-catenin or adenomatous polyposis coli (APC) gene mutations leading intranuclear accumulation beta-catenin. Since low-grade sarcomas in general lack since reactive would expected it, we predicted nuclear expression...
Low-grade fibromyxoid sarcoma (LGFMS) is an indolent, late-metastasizing malignant soft-tissue tumor that often mistaken for either more benign or types. Cytogenetic analyses have identified a recurrent balanced translocation t(7;16) (q32-34;p11), later shown by molecular genetic approaches to result in FUS/CREB3L2 fusion gene. Whereas preliminary studies suggest this gene rearrangement specific LGFMS, its incidence type and the possible existence of variant genes not yet been addressed. For...
An immunohistochemical study to determine the pattern of immunoreactivity for bcl-2 oncoprotein was performed in 380 spindle cell tumors soft tissue, skin, serosal surfaces, and gastrointestinal tract. The cases studied included examples benign, reactive proliferations benign malignant neoplasms, including nodular fasciitis (10), fibromatosis (5), dermatofibroma dermatofibrosarcoma protuberans (18), Kaposi's sarcoma (15), lipomatous (24), smooth muscle (35), neural/peripheral nerve sheath...