Bissan Al‐Lazikani
A5007910628- Computational Drug Discovery Methods
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Bioinformatics and Genomic Networks
- Cancer Genomics and Diagnostics
- Genetics, Bioinformatics, and Biomedical Research
- Eicosanoids and Hypertension Pharmacology
- Prostate Cancer Treatment and Research
- Protein Structure and Dynamics
- Cholesterol and Lipid Metabolism
- Colorectal Cancer Treatments and Studies
- Microbial Natural Products and Biosynthesis
- Protein Degradation and Inhibitors
- Heat shock proteins research
- Cancer, Hypoxia, and Metabolism
- Machine Learning in Bioinformatics
- Pharmacogenetics and Drug Metabolism
- Enzyme Structure and Function
- Gene expression and cancer classification
- Mass Spectrometry Techniques and Applications
- Advanced Proteomics Techniques and Applications
- RNA and protein synthesis mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Click Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
The University of Texas MD Anderson Cancer Center
2022-2024
Institute of Cancer Research
2014-2023
Cancer Research UK
2012-2022
University of Cambridge
1997-2022
Institute of Cancer Research
2020-2022
European Bioinformatics Institute
2005-2011
Wellcome Trust
2005-2010
Biocompatibles (United Kingdom)
2008
Mundipharma (United Kingdom)
2004-2007
Imperial College London
2005
ChEMBL is an Open Data database containing binding, functional and ADMET information for a large number of drug-like bioactive compounds. These data are manually abstracted from the primary published literature on regular basis, then further curated standardized to maximize their quality utility across wide range chemical biology drug-discovery research problems. Currently, contains 5.4 million bioactivity measurements more than 1 compounds 5200 protein targets. Access available through...
Schistosoma mansoni is responsible for the neglected tropical disease schistosomiasis that affects 210 million people in 76 countries. Here we present analysis of 363 megabase nuclear genome blood fluke. It encodes at least 11,809 genes, with an unusual intron size distribution, and new families micro-exon genes undergo frequent alternative splicing. As first sequenced flatworm, a representative Lophotrochozoa, it offers insights into early events evolution animals, including development...
Abstract The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number possible combinations vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large combination dataset, consisting 11,576 experiments from 910 across 85 molecularly characterized cell lines, and results a DREAM Challenge evaluate computational strategies for...
canSAR (http://cansar.icr.ac.uk) is a publicly available, multidisciplinary, cancer-focused knowledgebase developed to support cancer translational research and drug discovery. integrates genomic, protein, pharmacological, chemical data with structural biology, protein networks druggability data. widely used rapidly access information help interpret experimental in discovery context. Here we describe major enhancements including new data, improved search browsing capabilities, disease cell...
canSAR (http://cansar.icr.ac.uk) is a public, freely available, integrative translational research and drug discovery knowlegebase. informs researchers to help solve key bottlenecks in cancer translation discovery. It integrates genomic, protein, pharmacological, chemical data with structural biology, protein networks unique, comprehensive orthogonal 'druggability' assessments. widely used internationally by academia industry. Here we describe major enhancements including new expanded data....
Abstract The Protein Data Bank in Europe-Knowledge Base (PDBe-KB, https://pdbe-kb.org) is a community-driven, collaborative resource for literature-derived, manually curated and computationally predicted structural functional annotations of macromolecular structure data, contained the (PDB). goal PDBe-KB two-fold: (i) to increase visibility reduce fragmentation contributed by specialist data resources, make these more findable, accessible, interoperable reusable (FAIR) (ii) place their...
One approach to identifying cancer-specific vulnerabilities and therapeutic targets is profile genetic dependencies in cancer cell lines. Here, we describe data from a series of siRNA screens that identify the kinase 117 lines ten types. By integrating screen with molecular profiling data, including exome sequencing show how vulnerabilities/genetic are associated mutations specific driver genes can be identified. additional sets into this analysis, protein-protein interaction also...
Abstract Polypharmacology plays an important role in defining response and adverse effects of drugs. For some mechanisms, experimentally mapping polypharmacology is commonplace, although this typically done within the same protein class. Four PARP inhibitors have been approved by FDA as cancer therapeutics, yet a precise mechanistic rationale to guide clinicians on which choose for particular patient lacking. The four drugs largely similar family inhibition profiles, but several differences...
Abstract canSAR (http://cansar.icr.ac.uk) is the largest, public, freely available, integrative translational research and drug discovery knowledgebase for oncology. integrates vast multidisciplinary data from across genomic, protein, pharmacological, chemical with structural biology, protein networks more. It also provides unique data, curation annotation crucially, AI-informed target assessment discovery. widely used internationally by academia industry. Here we describe significant...
The Protein Data Bank in Europe - Knowledge Base (PDBe-KB, https://pdbe-kb.org) is an open collaboration between world-leading specialist data resources contributing functional and biophysical annotations derived from or relevant to the (PDB). goal of PDBe-KB place macromolecular structure their biological context by developing standardised exchange formats integrating partner into a knowledge graph that can provide valuable insights. Since we described 2019, there have been significant...
Abstract We describe the Chemical Probes Portal (https://www.chemicalprobes.org/), an expert review-based public resource to empower chemical probe assessment, selection and use. probes are high-quality small-molecule reagents, often inhibitors, that important for exploring protein function biological mechanisms, validating targets drug discovery. The publication, dissemination use of provide means accelerate functional annotation proteins, study proteins in cell biology, physiology, disease...