A5113660053- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- Urinary Bladder and Prostate Research
- Health Systems, Economic Evaluations, Quality of Life
- Surgical Simulation and Training
- Pelvic floor disorders treatments
- Urological Disorders and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Clinical practice guidelines implementation
- Colorectal Cancer Surgical Treatments
- Genital Health and Disease
- Pediatric Urology and Nephrology Studies
- Global Cancer Incidence and Screening
- Kidney Stones and Urolithiasis Treatments
- Cancer, Lipids, and Metabolism
- Renal and Vascular Pathologies
- Advanced Radiotherapy Techniques
- Genomics and Phylogenetic Studies
- Bioinformatics and Genomic Networks
- Cancer survivorship and care
- Evolution and Genetic Dynamics
- Genomics and Chromatin Dynamics
Royal Marsden NHS Foundation Trust
2016-2025
Royal Marsden Hospital
2016-2025
Max Super Speciality Hospital
2024
Cancer Research UK Cambridge Center
2022
Guy's Hospital
2006-2020
Guy's and St Thomas' NHS Foundation Trust
2006-2016
Royal Ottawa Mental Health Centre
2016
KU Leuven
2016
The Prostate Centre
2016
St Thomas' Hospital
2003-2016
No AccessJournal of UrologyAdult Urology1 Oct 2019Salvage Radical Prostatectomy for Recurrent Prostate Cancer: Morbidity and Functional Outcomes from a Large Multicenter Series Open versus Robotic Approaches Paolo Gontero, Giancarlo Marra, Alessio, Claudia Filippini, Marco Oderda, Fernando Munoz, Estefania Linares, Rafael Sanchez-Salas, Ben Challacombe, Prokar Dasgupta, Sanchia Goonewardene, Rick Popert, Declan Cahill, David Gillatt, Raj Persad, Juan Palou, Steven Joniau, Thierry Piechaud,...
With our extensive experience of transperitoneal laparoscopic prostatectomy, we evaluated the advantages and disadvantages extraperitoneal approach by comparing 2 consecutive series each procedure.We reviewed 200 procedures performed surgeons. A total 100 (designated group 1) were compared to first cases 2).Mean operating time was 173 minutes in 1 shorter at 163 (p = 0.003). Mean blood loss (360 ml 1,375 2) transfusion rates (4% 1, 3% equivalent. There no major complications. Minor...
To describe a protocol for transperineal sector biopsies (TPSB) of the prostate and present clinical experience this technique in UK population.A retrospective review single-centre TPSB approach was undertaken that preferentially, but not exclusively, targeted peripheral zone with 24-38 cores using 'sector plan'. Procedures were carried out under general anaesthetic most patients. Between January 2007 August 2011, 634 consecutive patients underwent following indications: prior negative...
We compared standard robot-assisted radical prostatectomy and Retzius-sparing in a multicenter study using prospective patient reported outcome measures of functional recovery quality life plus pentafecta outcomes.Patient physician data on 483 patients who underwent from August 2017 to April 2020 by 3 experienced surgeons had been prospectively collected. Perioperative outcomes were analyzed SPSS software. Patient for urinary function, erectile function at baseline 7 days 1, 3, 6, 9 12...
To test the reproducibility of other series laparoscopic radical prostatectomy (LRP) for safety, efficacy and early oncological functional results.One hundred consenting patients with clinically localized adenocarcinoma prostate a Gleason sum < or = 8 opting surgery underwent LRP undertaken by one surgeon. Their mean (range) age was 62.2 (52-72) years, weight 78.8 (65-100) kg, specific antigen (PSA) level 8.0 (2-32) ng/mL, 6.0 (4-8). A five-port antegrade transperitoneal technique used in...
Objective To test the hypothesis that laparoscopic dismembered pyeloplasty offers same good results as open pyeloplasty, but without disadvantages of loin incision (which is painful, prolongs hospitalization and prevents a return to normal activities for several weeks) in treatment pelvi‐ureteric junction (PUJ) obstruction. Patients methods Fifty consecutive consenting patients presenting with PUJ obstruction underwent carried out by one surgeon using an extraperitoneal approach. Results Two...
Recent evidence has shown elevated levels of cell-free plasma DNA in cancer patients. The aim the present study was to quantify and compare patients with prostate cancer, prostatic intraepithelial neoplasia (PIN), benign hypertrophy (BPH) examine if it offered a useful diagnostic test. Blood samples were obtained from 37 attending clinic for biopsies. Samples taken prior biopsy, within 1 hour then 2 weeks later. extracted using QIAamp blood kit (Qiagen) measured, genome...
317 Background: Early intervention is potentially lifesaving in prostate cancer and a major limitation of outcomes with ethnicity deprivation being determinants inequalities that impact outcomes. The Man Van designed to address health barriers accessing healthcare affect novel community-based targeting high-risk groups using mobile clinical unit. These are particularly relevant for men from ethnic minorities lower socio-economic groups. Methods: A bespoke nurse-led unit was moved locations...
ABSTRACT Background Prostate specific antigen density (PSAd) is one of the strongest predictors clinically‐significant prostate cancer (csPCa) in risk calculators. There little evidence on effect volume diagnostic performance PSAd. Our aim was to define accuracy PSAd for predicting csPCa across volumes. Methods 548 patients who underwent magnetic resonance imaging (MRI) and biopsy were included this retrospective study. Patients grouped by volume; small (≤ 30 mL), medium (> < 50 large...
Abstract Background The risk of rupture large abdominal aortic aneurysms (AAAs) remains uncertain. This study aimed to provide data help decide whether or not operate on high-risk patients. Methods Clinicians were asked refer all patients with an AAA, even if unfit elderly. One hundred and ninety-two intact AAA 5 cm greater in diameter seen 9 years; 59 had no elective operation follow-up available for 57 at a minimum 2 years. Initial diameters 5·0–5·9 (n = 25) 6·0 more 32). Survival curves...
To report on the short-term functional and oncological results, from one institution, of high-intensity focused ultrasound (HIFU) for treating localized prostate cancer.Over a 3-year period, 43 patients with cancer were scheduled HIFU in primary (31) salvage (12) settings using second-generation Ablatherm device (EDAP, Lyon, France). Oncological failure was defined by several criteria, including biochemical (assessed both Phoenix definition nadir + 2 ng/mL) current Food Drug Administration...
To investigate causes of death in a UK cohort patients with prostate cancer.We examined 50,066 men cancer diagnosed between 1997 and 2006 reported to the Thames Cancer Registry (TCR) followed-up end 2007. The underlying cause was taken from certificate. Uptake PSA screening low during period studied. We relationship patient characteristics at diagnosis including age, stage, treatment (≤6 months diagnosis).In all, 20,181 deaths occurred period; 49.8% recorded as being due cancer, 17·8%...
There remains equipoise with regard to whether laparoscopic radical prostatectomy (LRP) or robot-assisted (RARP) has any benefit over the other. Despite this, there is a trend for increasing adoption of RARP at great cost health services across world. The aim was critically analyze learning curve and outcomes LRP two experience- volume-matched surgeons who have completed RARP.Two were compared respect their LRP. 531 550 LRPs analyzed from April 2003 until January 2012 relatively high-volume...
Most patients are stented after ureteroscopy for stone extraction. This practice necessitates a second procedure to remove the stent, with its inherent morbidity. The aim of our study was determine whether routine stenting ureter is really necessary ureteroscopy.This prospective evaluated 26 men and 18 women admitted elective distal ureteral fragmentation. stones ranged in size from 6 mm 1 cm. Of series, 16 (10 men) had been prior ureteroscopy. A 9F semirigid ureteroscope used 31 cases, 7.5F...
Overtreatment of localised prostate cancer is substantial despite increased use active surveillance. No randomised trials help define how to monitor patients or when initiate treatment with curative intent. A randomised, multicentre, intervention trial designed evaluate the safety an MRI-based surveillance protocol, standardised triggers for repeated biopsies and radical treatment. The aim reduce overtreatment cancer. 2000 men will be randomly allocated either according current practice at...
To determine current radical prostatectomy (RP) practice in the UK and compare surgical outcomes between techniques.All RPs performed 1 January 2011 31 December with data entered into British Association of Urological Surgeons (BAUS) database, were identified for analysis. Overall assessed subgroup analyses these outcomes, based on operative technique [open RP (ORP), laparoscopic (LRP) robot-assisted (RALP)], made. Continuous variables compared using Mann-Whitney U-test categorical Pearson...