Yong‐Jie Lu
A5063866219- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Genetic Associations and Epidemiology
- Cancer-related molecular mechanisms research
- Prostate Cancer Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Genomic variations and chromosomal abnormalities
- RNA modifications and cancer
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
- Molecular Biology Techniques and Applications
- Sarcoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Testicular diseases and treatments
- Amino Acid Enzymes and Metabolism
- Chromosomal and Genetic Variations
- RNA Research and Splicing
- Bioinformatics and Genomic Networks
- Nutrition, Genetics, and Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
Wuhan National Laboratory for Optoelectronics
2025
Huazhong University of Science and Technology
2017-2025
Center for Excellence in Brain Science and Intelligence Technology
2025
Chinese Academy of Sciences
2025
Kunming Institute of Zoology
2025
Southern Medical University
2007-2025
Queen Mary University of London
2015-2024
First Affiliated Hospital of Zhengzhou University
2019-2024
Sichuan University
2017-2024
Shijiazhuang Tiedao University
2023-2024
Abstract Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following vivo exposure to ionizing have not been documented. Here, we searched for 12 radiation-associated second malignancies different tumour types. Two somatic mutation characterize irrespective type. Compared with 319 radiation-naive tumours, tumours carry median extra 201 deletions genome-wide, sized 1–100 base pairs often microhomology at the...
Abstract It remains elusive whether some of the associations identified in genome-wide association studies prostate cancer (PrCa) may be due to regulatory effects genetic variants on CpG sites, which further influence expression PrCa target genes. To search for sites associated with risk, here we establish models predict methylation (N = 1,595) and conduct analyses risk (79,194 cases 61,112 controls). We identify 759 showing an association, including 15 located at novel loci. Among those 42...
Isolation of circulating tumor cells (CTCs) from peripheral blood has the potential to provide a far easier "liquid biopsy" than tissue biopsies, monitor cell populations during disease progression and in response therapies. Many CTC isolation technologies have been developed. We optimized Parsortix system, an epitope independent, size compressibility-based platform for CTCs isolation, making it possible harvest at speed sample volume comparable standard CellSearch system. captured more half...
Prostate cancer is significantly more common in Western men than Asian men, but the basis for this difference remains unknown. Because genomic studies of prostate are very limited, we used a genome-wide approach to reveal alterations Chinese cancers. We found significant reduction frequency certain somatic changes that commonly cancers, including 21q22.2-22.3 deletion, which involves TMPRSS2:ERG fusion gene, and 10q causes PTEN inactivation. Array results were confirmed by PCR-based...
Abstract Although genome-wide association studies (GWAS) for prostate cancer (PrCa) have identified more than 100 risk regions, most of the genes at these regions remain largely unknown. Here we integrate largest PrCa GWAS ( N = 142,392) with gene expression measured in 45 tissues 4458), including normal and tumor prostate, to perform a multi-tissue transcriptome-wide study (TWAS) PrCa. We identify 217 84 independent 1 Mb associated risk, 9 which are no significant SNP within 2 Mb. 23 TWAS...
Targeted therapies have yet to significant impact on the survival of patients with bladder cancer. In this study, we focused urea cycle enzyme argininosuccinate synthetase 1 (ASS1) as a therapeutic target in cancer, based our discovery prognostic and functional import ASS1 setting. expression status tumors from 183 Caucasian 295 Asian was analyzed, along its hypothesized association clinicopathologic features, including tumor size invasion. Furthermore, genetics, biology, implications loss...
Abstract Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS 1 ) is associated with age at prostate diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS 2 , adapted OncoArray) a multi-ethnic dataset 80,491 men (49,916 cases, 30,575 controls). any aggressive (Gleason ≥ 7, stage T3-T4, PSA 10 ng/mL, or nodal/distant metastasis)...
Castration-resistant prostate cancer (CRPC) is the major cause of death from cancer. Biomarkers to improve early detection and prediction CRPC especially using non-invasive liquid biopsies could outcomes. Therefore, we investigated plasma exosomal miRNAs associated with their potential for development into biomarkers resistance treatment. RNA-sequencing, which generated approximately five million reads per patient, was performed identify differentially expressed in 24 treatment-naive...
In this report, we summarize the first NTIRE challenge on light field (LF) image super-resolution (SR), which aims at super-resolving LF images under standard bicubic degradation with a magnification factor of 4. This develops new dataset called NTIRE-2023 for validation and test, provides toolbox BasicLFSR to facilitate model development. Compared single SR, major SR lies in how exploit complementary angular information from plenty views varying disparities. total, 148 participants have...