Luc Multigner
A5015309391- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Prostate Cancer Treatment and Research
- Pesticide Exposure and Toxicity
- Prostate Cancer Diagnosis and Treatment
- Air Quality and Health Impacts
- Sperm and Testicular Function
- Pancreatitis Pathology and Treatment
- Reproductive Biology and Fertility
- Genetic Associations and Epidemiology
- Birth, Development, and Health
- Hormonal and reproductive studies
- Reproductive Health and Technologies
- Global Cancer Incidence and Screening
- Enzyme Production and Characterization
- Climate Change and Health Impacts
- Estrogen and related hormone effects
- Glutathione Transferases and Polymorphisms
- Heavy Metal Exposure and Toxicity
- Prenatal Substance Exposure Effects
- Healthcare Systems and Practices
- Health Systems, Economic Evaluations, Quality of Life
- Genetic factors in colorectal cancer
- Health, Environment, Cognitive Aging
Institut de Recherche en Santé, Environnement et Travail
2016-2025
Université de Rennes
2015-2024
Inserm
2015-2024
École des Hautes Études en Santé Publique
2013-2024
Centre Hospitalier Universitaire de Rennes
2023
University of Southern California
2022
Hôpital Pontchaillou
2021
Centre Hospitalier Universitaire Pointe-à-Pitre
2011-2020
Université Rennes 2
2016
National Institutes of Health
2014
BACKGROUND: An increasing number of reports suggest that chemical and physical agents in the environment, introduced spread by human activity, may affect male fertility humans. We investigated relationships between exposure to environmental seminal characteristics, concentrations reproductive hormones serum men seeking infertility treatment. METHODS: studied 225 partners from consecutively recruited couples, who had their first consultation 1995 1998, Litoral Sur region Argentina, one most...
Determining whether environmental estrogens are associated with the risk of prostate cancer may have important implications for our general understanding this disease. The estrogenic insecticide chlordecone was used extensively in French West Indies, contaminating population more than 30 years. We analyzed relationship between exposure to and cancer.We investigated 623 men 671 controls. Exposure according case-control status, using either current plasma concentration or a cumulative index...
Chlordecone (Kepone) is an organochlorine insecticide that has been used as and fungicide. In the French West Indies, Guadeloupe Martinique, it was intensively applied to banana fields from 1973 1993 control root borers. This pesticide undergoes no significant biotic or abiotic degradation in environment still present soils where applied. It only 1999 health environmental authorities became aware of extent chlordecone pollution media, including soils, waterways, food chain. Earlier...
Abstract Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS 1 ) is associated with age at prostate diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS 2 , adapted OncoArray) a multi-ethnic dataset 80,491 men (49,916 cases, 30,575 controls). any aggressive (Gleason ≥ 7, stage T3-T4, PSA 10 ng/mL, or nodal/distant metastasis)...
Attrition in cohort studies challenges causal inference. Although inverse probability weighting (IPW) has been proposed to handle attrition association analyses, its relevance little studied this context. We aimed investigate ability correct for selection bias exposure-outcome estimation by addressing an important methodological issue: the specification of response model.A simulation study compared IPW method with complete-case analysis (CCA) nine response-mechanism scenarios (3 missing at...
A rare African ancestry-specific germline deletion variant in HOXB13 (X285K, rs77179853) was recently reported Martinican men with early-onset prostate cancer. Given the role of variation cancer, we investigated association between X285K and cancer risk a large sample 22 361 ancestry men, including 11 688 cases. The allele present only West ancestry, an frequency that ranged from 0.40% Ghana 0.31% Nigeria to 0% Uganda South Africa, range frequencies admixed North America Europe (0-0.26%)....
ABSTRACT To investigate whether a specific isotype of tubulin is involved in flagellar motility, we have developed and screened panel monoclonal antibodies (mAb) generated against sea urchin sperm axonemal proteins. Antibodies were selected for their ability to block the motility permeabilized models. The antitubulin mAb B3 completely inhibited, at low concentrations, models from four species. On immunoblots, recognized predominantly α-tubulin axonemes equally well brain α- β-tubulins....
Persistent organic pollutants have not been conclusively associated with length of gestation or preterm birth. Chlordecone is an organochlorine pesticide that has extensively used to control the banana root borer population in French West Indies. Data from Timoun Mother–Child Cohort Study conducted Guadeloupe between 2004 and 2007 were examine associations chlordecone concentrations maternal plasma rate birth 818 pregnant women. analyzed using multivariate linear regression for a Cox model...
Abstract Background Prostate cancer risk stratification using single-nucleotide polymorphisms (SNPs) demonstrates considerable promise in men of European, Asian, and African genetic ancestries, but there is still need for increased accuracy. We evaluated whether including additional SNPs a prostate polygenic hazard score (PHS) would improve associations with clinically significant multi-ancestry datasets. Methods In total, 299 previously associated were inclusion new PHS, LASSO-regularized...
Abstract Background Recent studies suggest that a M editerranean dietary pattern during pregnancy may influence outcomes. The aim of this study was to evaluate the effect adherence diet ( MD ) on fetal growth restriction FGR and preterm delivery PTD in F rench C aribbean island where population is largely A frican descent presents patterns similar . Methods Using data from TIMOUN Mother–Child Cohort Study conducted G uadeloupe W est I ndies) between 2004 2007, we analysed for 728 pregnant...
Is there evidence at the population level of associations between different male genital disorders, outside Scandinavian countries? At an international scale, is for a number correlations rates four reproductive disorders (hypospadias, cryptorchidism, testicular cancer and low sperm concentration). Some these outcomes have been shown in studies focusing on individuals mainly Nordic European countries. These associations, together with histological dysgenesis pattern tissue specimens,...
Although men of African ancestry have a high risk prostate cancer (PCa), no genes or mutations been identified that contribute to familial clustering PCa in this population. We investigated whether the ancestry–specific variant at 8q24, rs72725854, is enriched with family history 9052 cases, 143 cases from high-risk families, and 8595 controls ancestry. found allele be significantly associated earlier age diagnosis, more aggressive disease, (32% carried vs 23% without 12% controls). For two...
A CaCO3-crystal-growth inhibitor was isolated from human pancreatic stones by using EDTA demineralization, followed DEAE-Trisacryl chromatography. The found to be a phosphoglycoprotein with Mr 14017 and having an unusual chemical composition. It is characterized high (42%) acidic amino acid content, but lacks methionine gamma-carboxyglutamic acid. protein contains 2.65 mol of P/mol protein, as phosphoserine (2 mol) phosphothreonine (0.5 mol). Isoelectric focusing the yields one major band...