A5085797383- Birth, Development, and Health
- Air Quality and Health Impacts
- Musculoskeletal pain and rehabilitation
- Gestational Diabetes Research and Management
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Water Treatment and Disinfection
- Reading and Literacy Development
- Healthcare Systems and Practices
- Health Systems, Economic Evaluations, Quality of Life
- Pregnancy and Medication Impact
- Health, Environment, Cognitive Aging
- Indoor Air Quality and Microbial Exposure
- Obesity, Physical Activity, Diet
- Pregnancy and preeclampsia studies
- Health disparities and outcomes
- Noise Effects and Management
- Heavy Metal Exposure and Toxicity
- Childhood Cancer Survivors' Quality of Life
- Carcinogens and Genotoxicity Assessment
- Occupational Health and Safety Research
- Shoulder Injury and Treatment
- Per- and polyfluoroalkyl substances research
- Cognitive and developmental aspects of mathematical skills
- Fatty Acid Research and Health
Institut de Recherche en Santé, Environnement et Travail
2016-2025
Inserm
2015-2024
Université de Rennes
2015-2024
École des Hautes Études en Santé Publique
2018-2024
Centre Hospitalier Universitaire de Rennes
2015-2024
Laboratoire Traitement du Signal et de l'Image
2009-2018
Université Rennes 2
2015-2016
Foie, Métabolisme, Cancer
2015
National Institutes of Health
2014
Bicêtre Hospital
1998-2005
Background: Trihalomethanes (THMs) are widespread disinfection by-products (DBPs) in drinking water, and long-term exposure has been consistently associated with increased bladder cancer risk. Objective: We assessed THM levels water the European Union as a marker of DBP estimated attributable burden cancer. Methods: collected recent annual mean municipal 28 countries (EU28) from routine monitoring records. linear exposure–response function for average residential by pooling data studies...
Gestational weight gain differs according to pre-pregnancy body mass index and is related the risks of adverse maternal child health outcomes. charts for women in different groups enable identification offspring at risk We aimed construct gestational reference underweight, normal weight, overweight, grades 1, 2 3 obese compare these with those obtained uncomplicated term pregnancies. used individual participant data from 218,216 pregnant participating 33 cohorts Europe, North America,...
Attrition in cohort studies challenges causal inference. Although inverse probability weighting (IPW) has been proposed to handle attrition association analyses, its relevance little studied this context. We aimed investigate ability correct for selection bias exposure-outcome estimation by addressing an important methodological issue: the specification of response model.A simulation study compared IPW method with complete-case analysis (CCA) nine response-mechanism scenarios (3 missing at...
Although prenatal exposure to water disinfection by-products does not appear affect the duration of gestation, its impact on fetal growth remains an open question. The authors studied associations between and restriction (FGR) preterm birth in PELAGIE cohort, a French cohort comprising 3,421 pregnant women recruited 2002 2006. Exposure was assessed by estimating levels trihalomethanes (THMs) tap during pregnancy maternal use measuring urinary trichloroacetic acid (TCAA) early nested...
Persistent organic pollutants have not been conclusively associated with length of gestation or preterm birth. Chlordecone is an organochlorine pesticide that has extensively used to control the banana root borer population in French West Indies. Data from Timoun Mother–Child Cohort Study conducted Guadeloupe between 2004 and 2007 were examine associations chlordecone concentrations maternal plasma rate birth 818 pregnant women. analyzed using multivariate linear regression for a Cox model...
Abstract Background Recent studies suggest that a M editerranean dietary pattern during pregnancy may influence outcomes. The aim of this study was to evaluate the effect adherence diet ( MD ) on fetal growth restriction FGR and preterm delivery PTD in F rench C aribbean island where population is largely A frican descent presents patterns similar . Methods Using data from TIMOUN Mother–Child Cohort Study conducted G uadeloupe W est I ndies) between 2004 2007, we analysed for 728 pregnant...
Sub-Sahara Africa (SSA) children are at high-risk neurodevelopmentally due to the prevalence of infectious disease, nutritional deficiencies and compromised caregiving. However, few mental health screening measures readily available for general use. The Strengths Difficulties Questionnaire (SDQ) has been used as a measure in SSA, but its psychometric properties not well understood. Five hundred sixty-six mothers completed SDQ their 6-year-old rural Benin north Cotonou. These were who had...
This study aims to validate a conceptual model for shoulder pain risk factors in two independent samples of male industrial workers: the Cosali cohort (n = 334) and one pharmaceutical company 487). Direct indirect relationships between work organization (automatic speed machine or movement product pace dependent on customers' demand), psychosocial (Job strain model), biomechanical (working with abducted arms, working arms at above level, perceived physical exertion), stress, were explored...
Over the last decades, prevalence of childhood respiratory conditions has dramatically increased worldwide. Considering time spent in enclosed spaces, indoor air pollutants are major interest to explain part this increase. This study aimed measure concentrations known or suspected affect health that present dwellings order assess children's exposure. Measurements were taken 150 homes with at least one child, Brittany (western France), 18 volatile organic compounds (among which four aldehydes...
We examined the association between exposure during pregnancy to trihalomethanes, most common water disinfection by-products, and birth outcomes in a European cohort study (Health Impacts of Long-Term Exposure Disinfection By-Products Drinking Water). took into account through different uses, measures toxicity, genetic susceptibility.We enrolled 14,005 mothers (2002-2010) their children from France, Greece, Lithuania, Spain, UK. Information on lifestyle- water-related activities was...
Are persistent organic pollutants (POPs) associated with a diminished ovarian reserve (DOR) in women of reproductive age?Amongst 17 POPs detected over 20% serum samples, only p,p'-DDE was significantly an increased risk DOR, and β-hexachlorocyclohexane (β-HCH) decreased DOR whilst mixture analyses yielded non-significant associations did not detect any interactions between POPs.Animal studies have shown that several can alter folliculogenesis increase follicle depletion. However, few been...
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Prostate segmentation in 3-D transrectal ultrasound images is an important step the definition of intra-operative planning high intensity focused (HIFU) therapy. This paper presents two main approaches for semi-automatic methods based on discrete dynamic contour and optimal surface detection. They operate require a minimal user interaction. are considered both alone or sequentially combined, with without postregularization, applied anisotropic isotropic volumes. Their performance, using...