A5046164327- Stress Responses and Cortisol
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Pituitary Gland Disorders and Treatments
- Neuroendocrine regulation and behavior
- Growth Hormone and Insulin-like Growth Factors
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Obesity, Physical Activity, Diet
- Estrogen and related hormone effects
- Tryptophan and brain disorders
- Adrenal and Paraganglionic Tumors
- Circadian rhythm and melatonin
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Sexual Differentiation and Disorders
- Hormonal and reproductive studies
- Ovarian function and disorders
- Eating Disorders and Behaviors
- Sleep and related disorders
- Child and Adolescent Psychosocial and Emotional Development
- Sleep and Wakefulness Research
- Nutritional Studies and Diet
- Reproductive System and Pregnancy
National and Kapodistrian University of Athens
2016-2025
Children's Hospital Agia Sophia
2016-2025
Agricultural University of Athens
2023-2025
Academy of Athens
2015-2024
Biomedical Research Foundation of the Academy of Athens
2015-2024
Walter de Gruyter (Germany)
2014-2024
Center for Children
2018-2024
University Hospital Leipzig
2014-2024
Turku University of Applied Sciences
2018-2024
National Research Center for Maternal and Child Health
2022-2024
<h3>Objective.</h3> —This article defines stress and related concepts reviews their historical development. The notion of a system as the effector syndrome is suggested, its physiologic pathophysiologic manifestations are described. A new perspective on human disease states associated with dysregulation provided. <h3>Data Sources.</h3> —Published original articles from animal studies selected reviews. Literature was surveyed utilizing MEDLINE the<i>Index Medicus</i>. <h3>Study...
<h3>Objective.</h3> —This article defines stress and related concepts reviews their historical development. The notion of a system as the effector syndrome is suggested, its physiologic pathophysiologic manifestations are described. A new perspective on human disease states associated with dysregulation provided. <h3>Data Sources.</h3> —Published original articles from animal studies selected reviews. Literature was surveyed utilizing MEDLINE the<i>Index Medicus</i>. <h3>Study...
The availability of nutrients influences cellular growth and survival by affecting gene transcription. Glucocorticoids also influence transcription have diverse activities on cell growth, energy expenditure, survival. We found that the arrest-specific 5 (Gas5) noncoding RNA, which is abundant in cells whose has been arrested because lack or factors, sensitized to apoptosis suppressing glucocorticoid-mediated induction several responsive genes, including one encoding inhibitor 2. Gas5 bound...
Abstract Sleep apnea and associated daytime sleepiness fatigue are common manifestations of mainly obese middle-aged men. The onset sleep peaks in middle age, its morbid mortal sequelae include complications from accidents cardiovascular events. pathophysiology remains obscure. purpose this study was to test three separate, albeit closely related, hypotheses. 1) Does contribute the previously reported changes plasma cytokine (tumor necrosis factor-α interleukin-6) leptin levels independently...
Total sleep restriction in humans is associated with increased daytime sleepiness, decreased performance, and hormonal/metabolic disturbances. The effects of mild chronic that mimic real life are not known. To assess the modest from 8 to 6 h/night for 1 wk, 25 young, healthy, normal sleepers (12 men 13 women) were studied 12 consecutive nights laboratory. After wk restriction, although subjects' nighttime was deeper, subjects significantly sleepier (multiple latency test) performed worse...
Excessive daytime sleepiness (EDS) and fatigue are frequent symptoms in the general population chief complaint of majority patients at Sleep Disorders Centers. There is evidence that inflammatory cytokines tumor necrosis factor-alpha (TNF alpha), interleukin-1beta (IL-1beta), IL-6 involved physiological sleep regulation their administration to humans associated with fatigue. To explore whether plasma levels TNF alpha, IL-1beta, elevated EDS, we measured morning 12 apneics, 11 narcoleptics, 8...
To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients.A multidisciplinary, multispecialty task force experts critical care medicine was convened from membership Society Critical Care Medicine European Intensive Medicine. In addition, international endocrinology were invited to participate.The members reviewed published literature provided expert opinion which derived. The developed using a modified Delphi...
Measurement of adrenocorticotropin levels in plasma from the inferior petrosal sinuses patients with Cushing's syndrome can distinguish adrenocorticotropin-secreting pituitary tumors (Cushing's disease) other causes syndrome, principally ectopic secretion an occult tumor. However, it is unknown whether such measurement consistently identifies disease and testing corticotropin-releasing hormone (CRH) enhances value procedure.
Although insomnia is, by far, the most commonly encountered sleep disorder in medical practice, our knowledge regard to its neurobiology and significance is limited. Activation of hypothalamic-pituitary-adrenal axis leads arousal sleeplessness animals humans; however, there a paucity data regarding activity insomniacs. We hypothesized that chronic associated with increased plasma levels ACTH cortisol. Eleven young insomniacs (6 men 5 women) 13 healthy controls (9 4 without disturbances,...
Primary depression can be associated with substantial hypercortisolism, thus prompting some researchers to suggest that shares pathophysiologic features Cushing's disease. Clinically, difficult or impossible distinguish from mild early disease is depressive features. The purpose of this study was evaluate whether the pituitary-adrenal responses ovine corticotropin-releasing hormone could help clarify mechanism hypercortisolism in and assist differential diagnosis these disorders. As compared...
Chronic fatigue syndrome is characterized by persistent or relapsing debilitating for at least 6 months in the absence of a medical diagnosis that would explain clinical presentation. Because primary glucocorticoid deficiency states and affective disorders putatively associated with arousal-producing neuropeptide CRH can be similar symptoms, we report here study functional integrity various components hypothalamic-pituitary-adrenal axis patients meeting research case criteria chronic...
Inbred Lewis (LEW/N) female rats develop an arthritis in response to group A streptococcal cell wall peptidoglycan polysaccharide (SCW), which mimics human rheumatoid arthritis. Histocompatible Fischer (F344/N) do not the same SCW stimulus. To evaluate this difference inflammatory reactivity, we examined function of hypothalamic-pituitary-adrenal (HPA) axis and its ability modulate development LEW/N F344/N rats. We have found that, contrast rats, had markedly impaired plasma corticotropin...
To examine the joint effect of insomnia and objective short sleep duration on hypertension risk. Representative cross-sectional study. Sleep laboratory. 1,741 men women randomly selected from central Pennsylvania. None. Insomniawas defined by a complaint with ≥ 1 year, while poor sleepwas as difficulty falling asleep, staying or early final awakening. Polysomnographic was classified into 3 categories: 6 h (top 50% sample); 5-6 (approximately third quartile ≤ 5 bottom sample). Hypertension...