A5005766189- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Biochemical Analysis and Sensing Techniques
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Growth Hormone and Insulin-like Growth Factors
- Nutritional Studies and Diet
- Cancer, Lipids, and Metabolism
- Pharmacology and Obesity Treatment
- Lipid metabolism and disorders
- Cardiovascular Disease and Adiposity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Obesity, Physical Activity, Diet
- Diabetes Management and Research
- Birth, Development, and Health
- Nutrition and Health in Aging
- HIV-related health complications and treatments
- Dietary Effects on Health
- Biomarkers in Disease Mechanisms
Beth Israel Deaconess Medical Center
2016-2025
Harvard University
2016-2025
VA Boston Healthcare System
2016-2025
Brigham and Women's Hospital
2006-2024
Boston Medical Center
2013-2024
Boston University
2013-2024
Translational Research Institute for Metabolism and Diabetes
2024
University of Groningen
2024
University Medical Center Groningen
2024
Beth Israel Deaconess Hospital
1995-2023
There is considerable epidemiological evidence that shift work associated with increased risk for obesity, diabetes, and cardiovascular disease, perhaps the result of physiologic maladaptation to chronically sleeping eating at abnormal circadian times. To begin understand underlying mechanisms, we determined effects such misalignment between behavioral cycles (fasting/feeding sleep/wake cycles) endogenous on metabolic, autonomic, endocrine predictors risk. Ten adults (5 female) underwent a...
Disruptions in hypothalamic-gonadal and other endocrine axes due to energy deficits are associated with low levels of the adipocyte-secreted hormone leptin may result hypothalamic amenorrhea. We hypothesized that exogenous recombinant replacement would improve reproductive neuroendocrine function women amenorrhea.Eight amenorrhea strenuous exercise or weight were studied for one month before receiving human then while treatment up three months. Six control subjects received no a mean (+/-SD)...
Background— Several studies have documented an inverse association between adherence to the Mediterranean diet and risk of coronary heart disease (CHD), but few data are available on relationship stroke. Methods Results— For present study, 74 886 women 38 63 years age in Nurses’ Health Study, a cohort study female nurses, without history cardiovascular diabetes were followed up from 1984 2004. We computed Alternate Diet Score self-reported dietary collected through validated food frequency...
Background. Recent epidemiologic investigations have suggested an association between increased blood levels of insulin-like growth factor 1 (IGF-1) and risk prostate cancer Our goal was to determine whether exists serum IGF-1 one its binding proteins, factorbinding protein 3 (IGFBP-3), risk. Methods: An immunoradiometric assay used quantify IGFBP-3 in samples as part a populationbased, case-control study Sweden. The population comprised 210 patients with newly diagnosed, untreated 224...
To elucidate the role of leptin in regulating neuroendocrine and metabolic function during an acute fast, six to eight healthy, lean men were studied under four separate conditions: a baseline fed state three 72-hour fasting studies with administration either placebo, low-dose recombinant-methionyl human (r-metHuLeptin), or replacement-dose r-metHuLeptin designed maintain serum at levels similar those state. Replacement-dose administered prevents starvation-induced changes...
Resistin is a novel adipocyte-secreted hormone proposed to link obesity with diabetes. Studies in mice have revealed conflicting data however, and the physiological role of circulating resistin humans remains unknown. We conducted cross-sectional studies 123 middle-aged women 120 healthy young subjects found that serum levels did not correlate markers adiposity, including body mass index, waist-to-hip ratio, or fat mass, insulin resistance assessed by homeostasis model, lipid profile, leptin...
To elucidate the role of leptin in regulating neuroendocrine and metabolic function during an acute fast, six to eight healthy, lean men were studied under four separate conditions: a baseline fed state three 72-hour fasting studies with administration either placebo, low-dose recombinant-methionyl human (r-metHuLeptin), or replacement-dose r-metHuLeptin designed maintain serum at levels similar those state. Replacement-dose administered prevents starvation-induced changes...
Adiponectin, an adipocyte-secreted hormone, is closely and inversely associated with insulin resistance was recently found to be independently endometrial cancer. Because in the setting of obesity has also been development breast cancer, we have hypothesized that decreased adiponectin levels might underlie association between cancer obesity/insulin resistance. We evaluated occurrence a case-control study comprising 174 women newly diagnosed, histologically confirmed 167 controls. inverse,...
The impact of overall dietary patterns that reflect actual eating behaviors on mortality caused by cardiovascular or other chronic diseases is largely unknown.We prospectively evaluated the relation between and risk cardiovascular, cancer, all-cause among 72,113 women who were free myocardial infarction, angina, coronary artery surgery, stroke, diabetes mellitus, cancer followed up from 1984 to 2002. Dietary derived factor analysis based validated food frequency questionnaires administered...