A5032736429- Adipose Tissue and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Vitamin D Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Thyroid Disorders and Treatments
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Vitamin C and Antioxidants Research
- Muscle metabolism and nutrition
- Growth Hormone and Insulin-like Growth Factors
- Metabolism, Diabetes, and Cancer
- TGF-β signaling in diseases
- Metabolism and Genetic Disorders
- Clusterin in disease pathology
- Mitochondrial Function and Pathology
- Cell Adhesion Molecules Research
- Cellular transport and secretion
- Exercise and Physiological Responses
- Neuroscience of respiration and sleep
- Ophthalmology and Eye Disorders
- High Altitude and Hypoxia
- Cardiovascular Disease and Adiposity
- Child Abuse and Related Trauma
- Cancer Risks and Factors
- Biomarkers in Disease Mechanisms
MRC Epidemiology Unit
2024
University of Cambridge
2024
Prince Philip Hospital
2022
Beth Israel Deaconess Medical Center
2012-2021
Harvard University
2012-2021
Newcastle upon Tyne Hospitals NHS Foundation Trust
2021
Aristotle University of Thessaloniki
2018-2021
Royal Victoria Infirmary
2020
London North West Healthcare NHS Trust
2020
Northwick Park Hospital
2020
Irisin has been proposed to be a myokine mediating the effect of exercise on adipocyte browning. The physiology irisin in humans is not completely understood.To study healthy individuals with different age and fitness levels explore direct effects muscle metabolism.Treadmill studies were conducted measure circulating at baseline response among old young, physically active sedentary individuals. Also, high- moderate-intensity swimming was performed adolescent men women intensity time course...
The myokine irisin may increase energy expenditure and affect metabolism.The objective of the study was to elucidate predictors whether circulating have day-night rhythm in humans.This an observational, cross-sectional with additional 24-hour prospective observational arm (day-night substudy) two interventional arms (mixed meal substudy exercise substudy).The conducted at Hellenic Military School Medicine (Thessaloniki, Greece).One hundred twenty-two healthy, young individuals were subjected...
Objective Exercise improves weight status and metabolism. Irisin, a novel myokine, may be involved in the regulation of metabolic function. The effect an exercise dietary lifestyle intervention for 1‐year on irisin, adipokines (leptin, adiponectin, resistin) inflammatory markers (C‐reactive protein (CRP), soluble tumor necrosis factor receptor II (sTNFR‐II) was evaluated, predictors irisin levels were characterized obese children. Methods Parameters assessed at baseline follow‐up 65 children...
Skeletal muscle is considered to be an endocrine organ that secretes a number of myokines including follistatin (FST), myostatin (MSTN), activin A, and the newly identified irisin. Irisin's biology function exhibit similarities with functions FST-MSTN-activin A axis. It remains unknown whether there any interplay among these molecules. The aim this study examine potential associations irisin FST, MSTN, axis.Two observational studies were performed evaluate other three peptides. Study...
We assessed glucose uptake in different tissues type 2 diabetes (T2D), prediabetes, and control subjects to elucidate its impact the development of whole-body insulin resistance T2D. Thirteen T2D, 12 10 subjects, matched for age BMI, underwent OGTT abdominal subcutaneous adipose tissue (SAT) biopsies. Integrated 18F-FDG PET MRI were performed during a hyperinsulinemic euglycemic clamp asses rate (MRglu) several tissues. MRglu skeletal muscle, SAT, visceral (VAT), liver was significantly...
Abstract Purpose Patients with Graves’ orbitopathy can present asymmetric disease. The aim of this study was to identify clinical characteristics that distinguish from unilateral and symmetric orbitopathy. Methods This a multi-centre new referrals 13 European Group on Orbitopathy (EUGOGO) tertiary centres. New patients presenting over 4 month period diagnosis were included. Patient demographics collected examination performed based previously published protocol. categorized as having...
Mitochondrial diseases are a group of common inherited causing disruption oxidative phosphorylation. Some patients with mitochondrial disease have endocrine manifestations, diabetes being predominant but also include hypogonadism, hypoadrenalism and hypoparathyroidism. There been major developments in over the last decade that implications for all patients. The collection large cohorts has better defined phenotype majority abnormalities involvement several other systems. This means...
The association between chronic lymphocytic thyroiditis (CLT) and thyroid cancer is an interesting topic. aim of the present study was to evaluate if demographic histological characteristics as well long-term outcome different in children adolescents with without CLT.The medical records (≤21 years old) were reviewed. following data recorded: gender, year age at diagnosis, family history cancer, external radiation therapy, type (papillary variants, follicular variants), tumour size,...
Abstract Objectives To audit implementation of a local protocol for the treatment vitamin D deficiency (VDD) among patients hospitalized Coronavirus Disease 2019 (COVID-19), including an assessment prevalence VDD in these patients, and potential associations with disease severity fatality. Design This was not study or clinical trial, but rather retrospective interim (Newcastle-upon-Tyne Hospitals Registration No. 10075) care pathway COVID-19-related illness. The Information (Caldicott)...
Breast cancer is associated with obesity, possibly due to direct effects of adipokines and myokines, such as omentin-1 irisin. In this study, we aimed evaluate irisin levels in women benign and/or malignant breast neoplasms vs. healthy controls. Disease-free individuals (N = 56) patients histologically proven 61) or tumor 96; subdivided into recently diagnosed/treatment-naïve 72) chemotherapy-treated 24) subgroups) were enrolled study. Demographic, biochemical, histological characteristics...
Breast cancer is the most common malignancy in women. Noninvasive biomarkers are needed for its early diagnosis and/or prognosis. The aim of this case-control study was comparison serum activins, follistatins, and members IGF family levels women with benign vs malignant breast neoplasms apparently healthy controls. Women (n = 100) or tumors 145) disease-free controls were recruited. subsequently subdivided into recently diagnosed/treatment-naive 112) chemotherapy-treated 33). Anthropometric,...
Both thyroid hormones and irisin increase energy expenditure induce browning of adipose tissue. However, physiology regulation remain largely unknown, existing data are mainly derived from observational studies. In this study, we aimed to elucidate whether changes in thyroid-axis alter circulating levels humans, thereby exerting a direct downstream effect on serum irisin.Samples cross-sectional evaluation two interventions were utilized, including patients who had previously undergone...
Background: Tissue factor (TF) combined with its ligand FVII initiates blood coagulation and intracellular signaling. Obese type 2 diabetic subjects have increased TF expression in their adipose tissue an risk for thrombotic complications. Here we address the role of TF/FVII on adipocyte functions. Materials methods: Subcutaneous fat was obtained by means needle aspiration from healthy volunteers, adipocytes were isolated after collagenase digestion. 3T3-L1 fibroblasts kept culture...
Abstract Context Obesity and classical growth factors are associated with thyroid cancer (TC). However, less is known regarding novel hormones such as follistatins activins. We hypothesized that serum follistatin but not activins would be increased in TC. Objective This work aimed to assess circulating levels of follistatins, activins, patients a history TC vs nonmalignant diseases. Methods A hospital-based, unmatched case-control study was conducted 170 thyroidectomized due...
Correction to: Altered Glucose Uptake in Muscle, Visceral Adipose Tissue, and Brain Predict Whole-Body Insulin Resistance may Contribute to the Development of Type 2 Diabetes: A Combined PET/MR StudyHorm Metab Res 2018; 50(08): 627-639DOI: 10.1055/a-0643-4739