A5035257768- Thyroid Disorders and Treatments
- Ophthalmology and Eye Disorders
- Thyroid Cancer Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Birth, Development, and Health
- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Pregnancy and preeclampsia studies
- Monoclonal and Polyclonal Antibodies Research
- Glaucoma and retinal disorders
- Adipose Tissue and Metabolism
- Pharmacological Effects and Assays
- Biomarkers in Disease Mechanisms
- Salivary Gland Disorders and Functions
- Effects of Environmental Stressors on Livestock
- Diet, Metabolism, and Disease
- Estrogen and related hormone effects
- T-cell and B-cell Immunology
- Meat and Animal Product Quality
- Ocular Diseases and Behçet’s Syndrome
- Multiple Sclerosis Research Studies
- SARS-CoV-2 and COVID-19 Research
- Animal Nutrition and Health
- Dermatological and COVID-19 studies
- Diabetes and associated disorders
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2020-2024
University of Padua
2024
Istituto Nazionale Genetica Molecolare
2024
University of Milan
2020-2024
Cardiff University
2014-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Ospedale Maggiore
2022
University Medical Center of the Johannes Gutenberg University Mainz
2021
Johannes Gutenberg University Mainz
2021
University Hospital of Wales
2016-2018
Graves' orbitopathy (GO) is the main extrathyroidal manifestation of disease (GD). Choice treatment should be based on assessment clinical activity and severity GO. Early referral to specialized centers fundamental for most patients with Risk factors include smoking, thyroid dysfunction, high serum level thyrotropin receptor antibodies, radioactive iodine (RAI) treatment, hypercholesterolemia. In mild active GO, control risk factors, local treatments, selenium (selenium-deficient areas) are...
The Controlled Antenatal Thyroid Screening (CATS) study investigated treatment of suboptimal gestational thyroid function (SGTF) on childhood cognition and found no difference in intelligence quotient (IQ) at 3 years between children treated untreated SGTF mothers. We have measured IQ the same age 9.5 included from normal (normal-GTF) One examiner, blinded to participant group, assessed children's (Wechsler Intelligence Scale for Children, Fourth Edition UK), long-term memory, motor...
Graves' disease is one of the most common autoimmune conditions, but treatment remains imperfect. This study explores first-in-human use antigen-specific immunotherapy with a combination two thyrotropin receptor (TSHR) peptides (termed ATX-GD-59) in hyperthyroidism.
Abstract Context Gut bacteria can influence host immune responses but little is known about their role in tolerance-loss mechanisms Graves disease (GD; hyperthyroidism caused by autoantibodies, TRAb, to the thyrotropin receptor, TSHR) and its progression orbitopathy (GO). Objective This work aimed compare fecal microbiota GD patients, with GO of varying severity, healthy controls (HCs). Methods Patients were recruited from 4 European countries (105 41 HCs) for an observational study...
Alemtuzumab, a highly effective treatment for multiple sclerosis (MS), predisposes to Graves disease (GD), with reportedly indolent course. To determine the type, frequency, and course of thyroid dysfunction (TD) in cohort alemtuzumab-treated patients MS United Kingdom. Case records who developed TD were reviewed. A total 41.1% (102 out 248; 80 female 22 male) TD, principally GD (71.6%). Median onset was 17 months (range 2 107) following last dose, majority (89%) within 3 years. Follow-up...
Abstract Context & Objectives The Controlled Antenatal Thyroid Screening (CATS) study was the first randomized controlled trial to investigate effects of treating suboptimal gestational thyroid function (SGTF) on child cognition. Since observational studies indicated that SGTF may also increase symptoms autism and attention-deficit/hyperactivity disorder (ADHD), CATS cohort used whether treatment mothers affected their children’s behavior. Design Participants Mothers (N = 475) completed...
Graves' Disease (GD) is an autoimmune condition in which thyroid-stimulating antibodies (TRAB) mimic hormone function causing hyperthyroidism. 5% of GD patients develop inflammatory orbitopathy (GO) characterized by proptosis and attendant sight problems. A major challenge to identify are most likely GO has relied on TRAB measurement. We screened sera/plasma from 14 GD, 19 13 healthy controls using high-throughput proteomics miRNA sequencing (Illumina's HiSeq2000 Agilent-6550 Funnel...
Background: Rituximab (RTX), a chimeric human-murine anti-CD20 monoclonal antibody, has been used for treatment of active moderate-severe Graves' orbitopathy (GO) since 2004 as second-line therapy in patients unresponsive to intravenous steroids. We conducted an open-label prospective study (EUDRACT 2012-001980-53) which were treated with single infusion only 100 mg RTX analyze the efficacy and safety this low dose. Methods: Seventeen patients, whom nine had disease that was...
SARS-CoV-2 infection and Covid-19 vaccines have been associated with thyroid disorders.
Women with breast cancer (BC) and antithyroid peroxidase (TPO) autoantibodies (TPOAb) have a better prognosis than women lacking TPOAb. Sera from TPOAb displayed immunoreactivity to BC tissue by immunofluorescence that was not apparent in without We hypothesize BC/thyroid shared antigen provides target for humoral or cell-mediated immune activity; candidates include the sodium/iodide symporter (expressed thyroid BC), cross-reacting epitopes TPO lactoperoxidase (LPO) itself. As association is...
Abstract Purpose Patients with Graves’ orbitopathy can present asymmetric disease. The aim of this study was to identify clinical characteristics that distinguish from unilateral and symmetric orbitopathy. Methods This a multi-centre new referrals 13 European Group on Orbitopathy (EUGOGO) tertiary centres. New patients presenting over 4 month period diagnosis were included. Patient demographics collected examination performed based previously published protocol. categorized as having...
Background: Thyroid autoimmunity, especially Graves' disease or hypothyroidism with positive autoantibodies (TRAb) to the thyrotropin receptor (TSHR), occurs in 30–40% of patients relapsing multiple sclerosis following treatment alemtuzumab (ALTZ). ALTZ therapy therefore provides a unique opportunity study evolution TRAb prior clinical presentation. can stimulate (TSAb), block (TBAb), not affect ("neutral") TSHR function, causing hyperthyroidism, hypothyroidism, euthyroidism, respectively....
Background Immunosuppressive therapy of Graves’ orbitopathy (GO) is indicated during the active phase disease. Intravenous steroids (IVGC) are effective in about 70% patients, although unresponsiveness or relapse observed. In previous studies, rituximab (RTX) has been shown to be inactivating moderate-to-severe GO when used early disease, but its optimal dosage never studied randomized clinical trials. Aim this study was compare efficacy and safety different doses RTX, based on a post-hoc...
Objective We have previously observed thyroid dysfunction, i.e. atypical thyroiditis (painless thyrotoxicosis associated with non-thyroidal illness syndrome), in patients severe acute respiratory syndrome coronavirus 2 disease (Covid-19). This study aimed to analyse the evolution of dysfunction over time. Methods One hundred eighty-three consecutive hospitalised for Covid-19 without known history were studied at hospital admission (baseline). Survivors offered 12-month longitudinal follow-up...
Children whose mothers had low thyroid hormone levels during pregnancy have been reported to decreased cognitive function. The research is part of the follow-on study Controlled Antenatal Thyroid Screening Study (CATS I), a randomised controlled trial which investigated impact treated vs. untreated level in women with primary outcome being child's IQ at age 3. No significant differences were found between and groups. These children are now aged 7 10 years aspects their functioning including...
Background: Small-scale studies correlated the presence of thyroid autoimmunity with both improved or worsened breast cancer outcome. Objectives: We aimed to clarify this association in a large cohort using phase III, randomized, controlled Taxotere as Adjuvant Chemotherapy Trial (TACT, CRUK01/001). Methods: TACT women >18 years old node-positive high-risk node-negative early (pT1–3a, pN0–1, M0), stored plasma (n = 1,974), taken 15.5 (median; IQR 7.0–24.0) months after surgery were studied....