A5049965593- Ophthalmology and Eye Disorders
- Pituitary Gland Disorders and Treatments
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Thyroid Disorders and Treatments
- Retinal Imaging and Analysis
- Corneal surgery and disorders
- Retinal and Optic Conditions
- Ophthalmology and Visual Impairment Studies
- Cerebral Venous Sinus Thrombosis
- Meningioma and schwannoma management
- Sympathectomy and Hyperhidrosis Treatments
- Intraocular Surgery and Lenses
- Ophthalmology and Visual Health Research
- Ocular Oncology and Treatments
- Vestibular and auditory disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Retinopathy of Prematurity Studies
- Spinal Fractures and Fixation Techniques
- Migraine and Headache Studies
- Leprosy Research and Treatment
- Health and Medical Studies
- S100 Proteins and Annexins
- Growth Hormone and Insulin-like Growth Factors
Johannes Gutenberg University Mainz
2015-2024
University Medical Center of the Johannes Gutenberg University Mainz
2015-2024
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2020-2021
Augenklinik Universitätsklinikum Würzburg
2021
GTx (United States)
2017-2019
Moorfields Eye Hospital NHS Foundation Trust
2016
University College London
2016
Philipps University of Marburg
2016
Ophthalmology Associates (United States)
2012
Berufsgenossenschaft Rohstoffe und chemische Industrie
2011
Graves' orbitopathy (GO) is the main extrathyroidal manifestation of disease (GD). Choice treatment should be based on assessment clinical activity and severity GO. Early referral to specialized centers fundamental for most patients with Risk factors include smoking, thyroid dysfunction, high serum level thyrotropin receptor antibodies, radioactive iodine (RAI) treatment, hypercholesterolemia. In mild active GO, control risk factors, local treatments, selenium (selenium-deficient areas) are...
To evaluate teprotumumab safety/efficacy in patients with thyroid eye disease (TED) who were nonresponsive or experienced a flare.The Treatment of Graves' Orbitopathy to Reduce Proptosis Teprotumumab Infusions an Open-Label Clinical Extension Study (OPTIC-X) is treatment and re-treatment trial following the placebo-controlled Phase 3 (Thyroid Eye Disease) Randomized, Placebo-Controlled, (OPTIC) trial.Patients previously received placebo (n = 37) 14) OPTIC.OPTIC nonresponders those flared...
Immunoglobulins stimulating the TSH receptor (TSI) influence thyroid function and likely mediate extrathyroidal manifestations of Graves' disease (GD).The aim this study was to assess clinical relevance TSI in GD patients with or without orbitopathy (GO), correlate levels activity/severity GO, compare sensitivity/specificity a novel bioassay (TSH-R) binding methods (TRAb).TSI were tested two reporter cell lines designed measure Igs TSH-R transmitting signals for cAMP/CREB/cAMP regulatory...
Disfiguring proptosis and functional impairment in patients with Graves' orbitopathy (GO) may lead to impaired earning capacity considerable indirect/direct costs.The aim of the study was investigate public health relevance GO.This cross-sectional performed between 2005 2009 at a multidisciplinary university orbital center.A total 310 unselected GO various degrees severity activity participated study.We conducted an observational measured work disability sick leave as well resulting costs...
Background: At the onset of thyroid-associated orbitopathy (TAO), most patients are hyperthyroid, while scarce data available on euthyroid/hypothyroid TAO. The aim this study was to assess prevalence, phenotype, and psychosocial burden with initially Methods: medical records 461 consecutive unselected TAO followed at a specialized joint thyroid–eye clinic were analyzed within retrospective cross-sectional study. Main outcome measures prevalence eu- or hypothyroid as well ophthalmic signs...
In patients with thyroid-associated orbitopathy (TAO), the dry eye syndrome occurs frequently, and symptoms signs of both disorders overlap making early accurate differential diagnosis difficult. A differentiation via specific markers is warranted.Tear fluid samples 120 subjects TAO, TAO + eye, controls were collected. The measured using matrix-assisted laser desorption ionization mass spectrometry. identified proteins tested antibody microarrays.Proteomics deregulated in eye. Compared...
Background Graves’ orbitopathy (GO) is subject to epidemiological and care-related changes. Aim of the survey was identify trends in presentation GO European Group On Orbitopathy (EUGOGO) tertiary referral centres initial management over time. Methods Prospective observational multicentre study. All new referrals with diagnosis within September–December 2019 were included. Clinical demographic characteristics, timelines therapeutic decisions recorded. Data compared a similar EUGOGO performed...
Diabetic retinopathy (DR) is the leading cause of blindness in people working age. The purpose this paper to report prevalence and cardiovascular associations diabetic maculopathy (DMac) Germany.The Gutenberg Health Study (GHS) a population-based study with 15,010 participants aged between 35 at 74 years from city Mainz district Mainz-Bingen. We determined weighted DR DMac by assessing fundus photographs persons diabetes GHS data base. Diabetes was defined as HbA1c ≥ 6.5%, known diagnosis...
Although several risk factors for retinal vein occlusion (RVO) are known, what triggers RVO is unclear in many cases. We aimed to evaluate the relevance of multiple patients with RVO. The Gutenberg Study an observational case-control study that assessed thrombophilic, cardiovascular, ophthalmic, and drug-related participants same number matched controls. Conditional logistic regression analysis was chosen estimate due factors. Of 92 RVO, 46 (50%) had central 31 (33.7%) branch 15 (16.3)...
In endocrine orbitopathy (EO), disfiguring proptosis and diplopia impair patients' quality of life both at home work.From late 2006 to the beginning 2008, 250 outpatients in an interdisciplinary thyroid eye clinic filled out a questionnaire about their life, occupational disability, use psychotherapy. 400 physicians who referred EO patients also participated survey on these issues.45% complained restrictions daily activities, 38% reported impaired self-perception. 36% were sick leave because...
Common autoimmune disorders tend to co-exist in the same subjects and cluster families. The objective of this study was determine prevalence co-morbidity patients with thyroid disease (AITD) without thyroid-associated orbitopathy (TAO). This a cross-sectional conducted at an academic tertiary referral centre. Of 1310 AITD [n = 777 or 59% Graves' (GD) n 533, 41% Hashimoto's thyroiditis (HT)] followed specialized joint thyroid-eye out-patient clinic, 176 (13·4%) had adult type polyglandular...
Purpose of review: In-vivo measurement retinal vascular calibers may be used as a tool to study the pathophysiology and clinical status microvasculature retina. The aim this was generate normative data for vessel parameters, evaluate relevance in systemic hypertension. Methods: Fundus photographs from 4309 participants Gutenberg Health Study were assessed using 'retinal analyzer' software (IMEDOS). We generated age sex-specific nomograms disease-free subpopulation 890 determining central...
A potentially altered protein expression profile in orbital tissue from patients with thyroid-associated orbitopathy (TAO) is suspected. To detect for the first time changes proteomic patterns of connective TAO and compare these control using mass spectrometry. Proteomics cross-sectional, comparative study. Two academic endocrine institutions. total 64 peripheral adipose samples were collected 39 25 subjects. Samples analyzed identified matrix-assisted laser desorption/ionization...