Diabetic retinopathy (DR) represents a severe complication of diabetes mellitus, characterized by irreversible visual impairment resulting from microvascular abnormalities. Since the global prevalence continues to escalate, DR has emerged as prominent area research interest. The development and progression encompass complex interplay pathological physiological mechanisms, such high glucose-induced oxidative stress, immune responses, vascular endothelial dysfunction, well damage retinal...

Age-related macular degeneration (AMD) is a prevalent degenerative disorder of the central retina, which holds global significance as fourth leading cause blindness. The condition characterized by multifaceted pathophysiology that involves aging, oxidative stress, inflammation, vascular dysfunction, and complement activation. complex interplay these factors contributes to initiation progression AMD. Current treatments primarily address choroidal neovascularization (CNV) in neovascular...

While randomized controlled trials (RCTs) are based on strict inclusion/exclusion criteria, non-interventional studies (NISs) might provide additional information to guide management in patients more representative the real-world setting. The aim of this study was compare baseline characteristics receiving intravitreal treatment NIS OCEAN with those from published RCTs.The ongoing enrolled treated ranibizumab for neovascular age-related macular degeneration (nAMD), diabetic oedema (DME) or...

Purpose: To investigate tolerability and safety of a new diagnostic device for 24-hour intraocular pressure monitoring in healthy subjects age-matched glaucoma patients. Patients Methods: Twenty (group 1) 20 patients 2) were included this prospective, single-center, open, observational parallel group study. The SENSIMED Triggerfish Sensor is soft disposable contact lens embedding telemetry chip strain gauge sensor continuous monitoring. was placed 1 eye 24 hours. Tolerability evaluated using...

Abstract Purpose To compare standard‐of‐care grid laser photocoagulation versus intravitreal ranibizumab ( IVR ) a combination of both in the treatment chronic (>3 months) macular oedema secondary to branch retinal vein occlusion. Methods Prospective, randomized, multicentre clinical trial. Thirty patients with best‐corrected visual acuity BCVA between 20/320 and 20/40 were randomized 1:1:1 receive or three monthly injections 0.5 mg followed by 3 months observation. Results Mean change...

Although several risk factors for retinal vein occlusion (RVO) are known, what triggers RVO is unclear in many cases. We aimed to evaluate the relevance of multiple patients with RVO. The Gutenberg Study an observational case-control study that assessed thrombophilic, cardiovascular, ophthalmic, and drug-related participants same number matched controls. Conditional logistic regression analysis was chosen estimate due factors. Of 92 RVO, 46 (50%) had central 31 (33.7%) branch 15 (16.3)...

Objectives: In this study, we evaluated clinical outcomes following a therapy switch to Faricimab, in patient cohort affected by neovascular age-related macular degeneration (nAMD), having received prior intravitreal anti-VEGF therapy. Methods: A retrospective investigation, including 28 eyes of 23 patients, treated for nAMD at the University Medical Center Mainz, Germany was performed. Faricimab conducted, due an inadequate response previous treatment. Visual acuity (VA), central retinal...

Background/Objectives: In glaucoma patients, the fluctuation in intraocular pressure during day seems to have an influence on progression of disease. The contact lens sensor (CLS) Triggerfish® from company SENSIMED records ocular dimensional changes for 24 h. aim was determine amplitude measurements with a before and after trabeculectomy (TE) patients. Methods: Twelve patients were included this prospective, single-arm, single-center, interventional study. All received CLS measurement h 8 ±...

This study analyses whether prematurity, retinopathy of prematurity (ROP), and associated factors lead to altered foveal shape in adulthood these alterations are with visual acuity.The Gutenberg Prematurity Eye Study is a German cohort prospective ophthalmologic examination (participants aged 18-52 years) individuals born preterm full-term that were examined spectral domain optical coherence tomography. Participants grouped according gestational age (GA) postnatal ROP status. Multivariable...

Aims To determine the prevalence of myopic maculopathy in general population Germany and to analyse potential associations with ocular systemic factors. Design The Gutenberg Health Study is a population-based study, including 15 010 participants aged 35–74 years. Methods Myopic was graded phakic eyes spherical equivalent ≤−6 D by assessing fundus photographs according recent international photographic classification system (META-PM). 801 519 (mean age 51.0±0.77 years) met conditions had...

Background: With this study, we investigate the short-term clinical outcomes of patients affected by diabetic macular edema (DME) after switching to intravitreal Faricimab (IVF) in a real-world setting. Methods: We conducted retrospective chart review on all treated for DME with IVF who showed insufficient responses prior anti-VEGF therapy. Data collected included baseline patient demographics, medical history, best-corrected visual acuity (BCVA), central retinal thickness (CRT) and volume...

To assess the serum autoantibody profile in patients with dry and exudative age-related macular degeneration compared healthy volunteers to detect potential biomarkers, e.g., markers for progression of disease.IgG Immunoreactivities were suffering from (AMD) (n = 20), treatment-naive AMD 29) 21). Serum was analysed by customized antigen microarrays containing 61 antigens. The statistical analysis performed univariate multivariate variance, predictive data-mining methods artificial neuronal...

To investigate the prevalence and new onset of depression anxiety among subjects with age-related macular degeneration (AMD) its association AMD in a large European cohort relatively good visual acuity. 11,834 participants enrolled German population-based Gutenberg Health Study were studied. was diagnosed by grading fundus photographs. Depression assessed Patient Questionnaire Generalized Anxiety Disorder-2 Scale, respectively. Logistic regression analyses performed adjusted for several...

Purpose We report visual and anatomical outcomes of chronic postoperative macular edema treated with a fluocinolone acetonide intravitreal implant. Method Retrospective study chronic, post-surgical CME Best registered acuity (BRVA), central retinal thickness (CRT), Goldmann tonometry intraocular pressure (IOP) were assessed over 24 months. The need for IOP lowering treatment, top-up therapy during follow-up, complications also assessed. Results analyzed 16 consecutive eyes patients Surgical...

Purpose: This study analyzed whether low birth weight is linked to prevalence and incidence of age-related maculopathy (AMD) in adulthood. Methods: The Gutenberg Health Study (GHS) a population-based, observational cohort Germany. GHS participants at an age from 35 74 years were included. An ophthalmologic examination with fundus photography was carried out. Fundus photographs graded according the Rotterdam Grading Scheme for AMD baseline 5-year follow-up examination. Participants divided...

Abstract Purpose We aimed to determine the prevalence of characteristics and pathologies vitreo‐macular interface within general population. Methods The Gutenberg Health Study is a population‐based study in Germany, including an ophthalmological examination with refraction, biometry optical coherence tomography ( OCT ) imaging. Characteristics were graded on volume scans visibility epiretinal membrane, full‐thickness macular hole, lamellar hole pseudohole. Overall age‐specific prevalences...

Abstract Purpose Anti-retinal autoantibodies are assumed to be associated with age-related macular degeneration (AMD). To our knowledge, this is the first evaluation of in human sera participants different stages AMD a large population-based, observational cohort study Germany. Methods The Gutenberg Health Study (GHS) Germany, including 15,010 aged between 35 and 74. Amongst others, non-mydriatic fundus photography (Visucam PRO NM™, Carl Zeiss Meditec AG, Jena, Germany) was performed. Fundus...

To identify risk factors for being a "reduced responder" to ranibizumab treatment in clinical setting patients with neovascular age-related macular degeneration.This retrospective study included 165 eyes of consecutive choroidal neovascularisation secondary neovascular, degeneration. Eyes were treated three intravitreal injections ranibizumab, followed by PRN (pro re nata) dosing thereafter. All reevaluated every four weeks and then six months. Reduced responders defined as loss visual...

Abstract Purpose Age-related macular degeneration (AMD) is a major cause of visual impairment and blindness. This study evaluates the incidence progression AMD in large German cohort. Methods The Gutenberg Health Study (GHS) population-based, prospective, observational cohort Germany that includes 15,010 participants between 35 74 years age. baseline examination, including fundus photography, was conducted 2007 2012, 5-year follow-up examination performed 2012 2017. grading photographs...

To report visual and anatomical outcomes of chronic/refractory diabetic macular edema (DME) treated with intravitreal fluocinolone acetonide implant.Retrospective, one arm, multicentric study.Between 2013 2018, 27 consecutive eyes 25 patients DME were a implant. Best registered acuity (BRVA), central retinal thickness (CRT), Goldmann tonometry intraocular pressure (IOP) assessed at 12 24 months. The need for IOP lowering treatment as well top-up therapy during the follow-up also assessed.The...