Karl J. Lackner
A5075174977- Systemic Lupus Erythematosus Research
- Glaucoma and retinal disorders
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Retinal Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Atherosclerosis and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Ophthalmology and Visual Impairment Studies
- Platelet Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Corneal surgery and disorders
- Cardiovascular Health and Disease Prevention
- Adipokines, Inflammation, and Metabolic Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Nitric Oxide and Endothelin Effects
- Health disparities and outcomes
- Diabetes and associated disorders
- Cardiac electrophysiology and arrhythmias
- Monoclonal and Polyclonal Antibodies Research
University Medical Center of the Johannes Gutenberg University Mainz
2016-2025
Johannes Gutenberg University Mainz
2016-2025
German Centre for Cardiovascular Research
2016-2025
Institute of Molecular Biology
2023-2025
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2011-2024
German Medical Association
2024
Institute of Clinical Cancer Research
2014-2023
University Medical Center Hamburg-Eppendorf
2011-2023
Walter de Gruyter (Germany)
2022-2023
St Vincent's Hospital Sydney
2023
Cardiac troponin testing is central to the diagnosis of acute myocardial infarction. We evaluated a sensitive I assay for early and risk stratification infarction.In multicenter study, we determined levels as assessed by assay, T, traditional necrosis markers in 1818 consecutive patients with suspected infarction, on admission 3 hours 6 after admission.For samples obtained admission, diagnostic accuracy was highest (area under receiver-operating-characteristic curve [AUC], 0.96), compared T...
While loneliness has been regarded as a risk to mental and physical health, there is lack of current community data covering broad age range. This study used large representative German adult sample investigate loneliness. Baseline the Gutenberg Health Study (GHS) collected between April 2007 2012 (N = 15,010; 35–74 years), were analyzed. Recruitment for community-based, prospective, observational cohort was performed in equal strata gender, residence decades. Measures provided by...
Background Variability of gene expression in human may link sequence variability and phenotypes; however, non-genetic variations, alone or combination with genetics, also influence traits have a critical role physiological disease processes. Methodology/Principal Findings To get better insight into the overall expression, we assessed transcriptome circulating monocytes, key cell involved immunity-related diseases atherosclerosis, 1,490 unrelated individuals investigated its association...
Cellular antioxidant enzymes such as glutathione peroxidase 1 and superoxide dismutase have a central role in the control of reactive oxygen species. In vitro data studies animal models suggest that these may protect against atherosclerosis, but little is known about their relevance to human disease.
<h3>Context</h3>Introduction of highly sensitive troponin assays into clinical practice has substantially improved the evaluation patients with chest pain.<h3>Objective</h3>To evaluate diagnostic performance a I (hsTnI) assay compared contemporary (cTnI) and their serial changes in diagnosis acute myocardial infarction (AMI).<h3>Design, Setting, Patients</h3>A total 1818 suspected coronary syndrome were consecutively enrolled at pain units University Heart Center Hamburg, Medical Mainz,...
As a competitive inhibitor of endothelial nitric oxide synthase, asymmetric dimethylarginine (ADMA) has been related to atherosclerotic disease. Little is known about the prognostic impact baseline ADMA determination. In prospective cohort 1908 patients with coronary artery disease, we assessed serum concentration in 1874 consecutive One hundred fourteen individuals developed primary end point death from cardiovascular causes or nonfatal myocardial infarction during mean follow-up 2.6+/-1.2...
Cardiovascular risk estimation by novel biomarkers needs assessment in disease-free population cohorts, followed up for incident cardiovascular events, assaying the serum and plasma archived at baseline. We report results from 2 cohorts such a continuing study.Thirty different pathophysiological pathways were evaluated 7915 men women of FINRISK97 cohort with 538 events 10 years (fatal or nonfatal coronary stroke events), which biomarker score was developed then validated 2551 Belfast...
Data regarding high-sensitivity troponin concentrations in patients presenting to the emergency department with symptoms suggestive of myocardial infarction may be useful determining probability and subsequent 30-day outcomes.
Hyperglycemia associated with inflammation and oxidative stress is a major cause of vascular dysfunction cardiovascular disease in diabetes. Recent data reports that selective sodium-glucose co-transporter 2 inhibitor (SGLT2i), empagliflozin (Jardiance®), ameliorates glucotoxicity via excretion excess glucose urine (glucosuria) significantly improves mortality type diabetes mellitus (T2DM). The overarching hypothesis hyperglycemia are upstream all other complications seen aim this study was...
Our aims were to evaluate the distribution of troponin I concentrations in population cohorts across Europe, characterize association with cardiovascular outcomes, determine predictive value beyond variables used ESC SCORE, test a potentially clinically relevant cut-off value, and improved eligibility for statin therapy based on elevated retrospectively.Based Biomarkers Cardiovascular Risk Assessment Europe (BiomarCaRE) project, we analysed individual level data from 10 prospective...
BackgroundThe relevance of blood lipid concentrations to long-term incidence cardiovascular disease and the lipid-lowering therapy for outcomes is unclear. We investigated risk associated with full spectrum bloodstream non-HDL cholesterol concentrations. also created an easy-to-use tool estimate probabilities a event modelled its reduction by treatment.MethodsIn this risk-evaluation risk-modelling study, we used Multinational Cardiovascular Risk Consortium data from 19 countries across...
Background While noise annoyance has become recognized as an important environmental stressor, its association to mental health hardly been studied. We therefore determined the of anxiety and depression explored contribution diverse sources overall annoyance. Patients Methods investigated cross-sectional data n = 15.010 participants Gutenberg Health Study (GHS), a population-based, prospective, single-center cohort study in Mid-Germany (age 35 74 years). Noise was assessed separately for...
The inflammatory and immune systems are altered in type 2 diabetes. Here, the aim was to profile response subjects with prediabetes diabetes a large population-representative sample.In total, 15,010 individuals were analyzed from population-based Gutenberg Health Study. Glucose status classified according HbA1c concentration history of diagnosis. All samples for white blood cells (WBCs), granulocytes, lymphocytes, monocytes, platelets, C-reactive protein (CRP), albumin, fibrinogen,...
Background and Purpose— Strokes have especially devastating implications if they occur early in life; however, only limited information exists on the characteristics of acute cerebrovascular disease young adults. Although risk factors manifestation atherosclerosis are commonly associated with stroke elderly, recent data suggests different causes for young. We initiated prospective, multinational European study Stroke Young Fabry Patients (sifap) to characterize a cohort patients. Methods—...
Stratification for subsequent coronary events among patients with artery disease (CAD) is of considerable interest because the potential to guide secondary preventive therapies. Recently, we identified eight microRNAs (miRNAs), which facilitated acute syndrome (ACS) diagnosis. In this study, aimed evaluate their role as prognostic biomarkers cardiovascular disease. The serum concentrations candidate miRNAs -miR-19a, miR-19b, miR-132, miR-140-3p, miR-142-5p, miR-150, miR-186, and miR-210 were...
Background Circulating microRNAs (miRNAs) have been described as potential diagnostic biomarkers in cardiovascular disease and particular, coronary artery (CAD). Few studies were undertaken to perform analyses with regard risk stratification of future events. miR-126, miR-197 miR-223 are involved endovascular inflammation platelet activation the diagnosis CAD. They identified a prospective study relation myocardial infarction. Objectives The aim our was further evaluate prognostic value...
Summary Monocytes play a central role in the inflammatory disease atherosclerosis. CD14+CD16+ monocytes are considered proinflammatory monocytes, as they have an increased capacity to produce cytokines, such TNF-α, and elevated various diseases. We hypothesized that patients with coronary artery (CAD) levels of associated inflammation markers. investigated 247 CAD 61 control subjects using flow cytometry. In addition serum concentrations IL-6, Hs-CRP were assessed. Patients had higher than...
Venlafaxine (V) is a mixed serotonin and noradrenaline reuptake inhibitor used as first-line treatment of depressive disorders. It metabolized primarily by the highly polymorphic cytochrome P450 (CYP) enzyme CYP2D6 to yield pharmacologically active metabolite, O-desmethylvenlafaxine (ODV), lesser extent CYP3A4, N-desmethylvenlafaxine (NDV).The aim this study was assess whether O-demethylation phenotype V has an impact on pharmacokinetics clinical outcome.In 100 patients treated with V, serum...