A5091652874- Hormonal and reproductive studies
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Neuropeptides and Animal Physiology
- Iron Metabolism and Disorders
- Plant tissue culture and regeneration
- Cerebrovascular and Carotid Artery Diseases
- Attention Deficit Hyperactivity Disorder
- Health Systems, Economic Evaluations, Quality of Life
- Complementary and Alternative Medicine Studies
- Pharmacological Effects and Assays
- IL-33, ST2, and ILC Pathways
- Blood Pressure and Hypertension Studies
- Lipoproteins and Cardiovascular Health
- Toxin Mechanisms and Immunotoxins
- Hemoglobinopathies and Related Disorders
- MicroRNA in disease regulation
- Hypothalamic control of reproductive hormones
- Statistical Methods in Clinical Trials
- Drug-Induced Adverse Reactions
- Psychometric Methodologies and Testing
- Mental Health Research Topics
- Circular RNAs in diseases
- Cardiovascular Health and Disease Prevention
- Urban Green Space and Health
Witten/Herdecke University
2018-2023
University of Bamberg
2021-2022
Universität Hamburg
2013-2020
University Medical Center Hamburg-Eppendorf
2013-2020
German Centre for Cardiovascular Research
2014-2019
TU Dortmund University
2018
Stratification for subsequent coronary events among patients with artery disease (CAD) is of considerable interest because the potential to guide secondary preventive therapies. Recently, we identified eight microRNAs (miRNAs), which facilitated acute syndrome (ACS) diagnosis. In this study, aimed evaluate their role as prognostic biomarkers cardiovascular disease. The serum concentrations candidate miRNAs -miR-19a, miR-19b, miR-132, miR-140-3p, miR-142-5p, miR-150, miR-186, and miR-210 were...
Background Circulating microRNAs (miRNAs) have been described as potential diagnostic biomarkers in cardiovascular disease and particular, coronary artery (CAD). Few studies were undertaken to perform analyses with regard risk stratification of future events. miR-126, miR-197 miR-223 are involved endovascular inflammation platelet activation the diagnosis CAD. They identified a prospective study relation myocardial infarction. Objectives The aim our was further evaluate prognostic value...
Importance and Objective Besides their role in diagnosis of acute myocardial infarction (MI), troponins may be powerful biomarkers for risk stratification the general population. The objective our study was to compare performance three troponin assays cardiovascular disease (CVD) prediction a population-based cohort without history CVD events. Design, Setting Participants Troponin I concentrations were measured using contemporary-sensitivity, high-sensitivity, super-sensitivity assay 7,899...
Background Atrial fibrillation is the most common serious abnormal heart rhythm, and a frequent cause of ischaemic stroke. Recent experimental studies, mainly in orchiectomised rats, report relationship between sex hormones atrial electrophysiology electroanatomy. We aimed to evaluate whether low testosterone levels are predictive for and/or stroke men women. Design methods The serum total were measured at baseline population cohort 7892 subjects (3876 male, 4016 female), aged 25-74 years,...
<h3>Objectives</h3> We hypothesised that soluble ST2 (sST2) levels can identify people with elevated risk of subsequent cardiovascular disease (CVD) and add to existing prediction algorithms. <h3>Background</h3> is a receptor for the inflammatory cytokine IL33. Increased sST2 have been associated heart failure death in acute myocardial infarction patients general population. <h3>Methods</h3> measured high-sensitivity 8444 men women (25–74 years) from FINRISK97 prospective population cohort....
Background Coronary heart disease is a leading cause of mortality worldwide. Iron deficiency, frequent comorbidity coronary disease, causes an increased expression transferrin receptor and soluble levels (sTfR) levels, while iron repletion returns sTfR to the normal physiological range. Recently, were proposed as potential new marker metabolism in cardiovascular diseases. Therefore, we aimed evaluate prognostic value circulating large cohort patients with disease. Methods Results The...
Most studies reporting on the association of circulating testosterone levels with type 2 diabetes in men are cross-sectional design. Reports relevance altered women scarce. Here, we evaluate role low serum for incident and a population setting 7706 subjects (3896 females). During mean follow up time 13.8 years, 7.8% developed diabetes. Significant correlations high density lipoprotein (HDL)-cholesterol (R = 0.21, p < 0.001), body-mass-index −0.23, waist-to-hip-ratio −0.21, 0.001) were...
Introduction. To examine whether midregional pro-adrenomedullin (MR-proADM) plasma concentrations predict incident cardiovascular outcomes in the general population. Natriuretic peptides (N-terminal pro-brain natriuretic peptide (NT-proBNP), B-type (BNP), and pro-atrial (MR-proANP)) were analyzed for comparison.Material methods. MR-proADM those of determined 8444 individuals FINRISK 1997 cohort. Patients followed 14 years (median). Cox regression analyses, discrimination, reclassification...
Abstract Background: Low circulating homoarginine has been associated with adverse cardiovascular (CV) outcome and mortality in patients at risk the general population. The present study aimed to define plasma reference intervals from a representative population sample improve stratification between healthy individuals risk. Methods: We determined age- sex-specific for subgroup of 786 participants (no CV disease or factors) Gutenberg Health Study. Homoarginine concentrations were measured...
Abstract In this single-center observational study with 1,206 participants, we prospectively evaluated SARS-CoV-2-antibodies (anti-S RBD) and vaccine-related adverse drug reactions (ADR) after basic booster immunization BNT162b2- ChAdOx1-S-vaccines in four vaccination protocols: Homologous BNT162b2-schedule second at either three or six weeks, homologous ChAdOx1-S-vaccination heterologous ChAdOx1-S/BNT162b2-schedule, each 12 weeks. All participants received a BNT162b2 booster. Blood samples...
Iron is essential in terms of oxygen utilization and mitochondrial function. The liver-derived peptide hepcidin has been recognized as a key regulator iron homeostasis. Since metabolism crucially linked to cardiovascular health, low was proposed potential new marker metabolism, we aimed evaluate the prognostic value large cohort patients with coronary heart disease (CHD). Serum levels were determined at baseline angiographically documented CHD. main outcome measure non-fatal myocardial...
Background Risk stratification among patients with coronary artery disease (CAD) is of considerable interest due to the potential guide secondary preventive therapies. Thus, we evaluated predictive value soluble urokinase-type plasminogen activator receptor (suPAR) levels for cardiovascular mortality and nonfatal myocardial infarction in CAD. Methods Results Plasma suPAR were measured a cohort 1703 documented CAD as evidenced by angiography-including 626 acute syndrome 1077 stable angina...
Analyses emphasizing gender-related differences in acute and long-term outcomes following MitraClip therapy for significant mitral regurgitation (MR) are rare.592 consecutive patients (75 ± 8.7 years, 362 men, 230 women) underwent clinical echocardiographic follow-up a median of 2.13 (0.99-4.02) years.Significantly higher prevalence cardiovascular comorbidities, renal failure, adverse parameters men resulted longer device time (p = 0.007) numbers implanted clips 0.0075), with equal...
The relevance of low testosterone concentrations for incident coronary heart disease (CHD) and mortality has been discussed in various studies. Here, we evaluate the predictive value baseline levels a large population-based cohort.We measured serum 7671 subjects (3710 male, 3961 female) FINRISK97 study.The median follow-up (FU) was 13.8 years. During FU, total 779 deaths from any cause, 395 CHD events were recorded. age-adjusted similar suffering during FU those without (men: 15.80 vs. 17.01...
Abstract Aims The increased incidence of heart failure in men suggests that endogenous sex hormones might play a role the development failure, but epidemiological data remain sparse. Here, we evaluated predictive value low testosterone levels on future large population‐based FINRISK97 study. Methods and results Baseline serum concentrations were measured 7855 subjects (3865 3990 women) During median follow‐up (FU) 13.8 years, total 564 events recorded. age‐adjusted baseline did not differ...
Meta-analytic evidence showed robust associations between the alliance in psychotherapeutic dyads and treatment outcomes. Recent studies have indicated that facets of positive mental health are additionally relevant predictors both success psychotherapy. However, impact patients' pre-therapy strengths on at beginning during has been scarcely examined.428 patients (62.4% female, Mage = 40.79), treated by 41 therapists, underwent cognitive behavioral therapy a German outpatient training...
Type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD) are two chronic diseases that cause a tremendous burden. To reduce this burden, several programmes for optimising the care these have been developed. In Germany, so-called management (DMPs), which combine components of Disease Management Chronic Care Model, applied. These DMPs proven effective. Nevertheless, there opportunities improvement. Current rarely address self-management disease, make no use peer support, provide...