Importance and Objective Besides their role in diagnosis of acute myocardial infarction (MI), troponins may be powerful biomarkers for risk stratification the general population. The objective our study was to compare performance three troponin assays cardiovascular disease (CVD) prediction a population-based cohort without history CVD events. Design, Setting Participants Troponin I concentrations were measured using contemporary-sensitivity, high-sensitivity, super-sensitivity assay 7,899...

The higher oestrogen concentrations in women have been suggested as the reason for their slower development of atherosclerosis compared with men. Oestrogen receptors located on macrophages, smooth muscle cells, and endothelial cells men, but it is not known whether protective effect at level arterial wall mediated by these receptors. It has reported that premenopausal fewer α atherosclerotic than normal coronary arteries.1 gene human receptor contains a polymorphism regulatory (upstream)...

Background and Purpose— Elevated fibrinogen levels are suggested to increase the risk of myocardial infarction stroke. Carriers A allele −455G/A polymorphism have increased plasma levels. We studied association this with stroke subtype in Stroke Aging Memory (SAM) cohort. Methods— The SAM cohort comprises 486 consecutive patients 55 85 years age who, 3 months after ischemic stroke, completed a detailed assessment. subtypes were examined MRI. genotype was determined by polymerase chain...

Variation in the outcome after aneurysmal subarachnoid hemorrhage (SAH) is not fully explained by known prognostic factors. APOE genotype most important genetic determinant of susceptibility to Alzheimer's disease, and it also shown be associated with traumatic brain injury. We studied association apolipoprotein E polymorphism SAH.A total 160 consecutive patients were admitted SAH a neurosurgical unit. The clinical assessment was performed Hunt Hess grading scale. severity bleeding as...

Summary Objective Apolipoprotein E ( APOE ) genotype is a regulator of hepatic lipoprotein metabolisms and has been linked with longevity. The relationship between plasma C‐reactive protein (CRP), which produced by the liver during inflammation, not studied in nonagenarians. aim present study was to establish whether related concentrations CRP lipids, or longevity among Design patients This cross‐sectional consisted 291 Finnish nonagenarians three previously described genotyped control...

Background: The susceptibility to alcoholism can be explained partially by genetic factors. Neuropeptide Y (NPY) has emerged as one potential factor contributing the development of alcoholism. A recent study indicated that NPY gene variant producing a leucine‐to‐proline substitution (T C at position 1128) was associated with 34% higher average alcohol consumption. Methods: subjects consisted 122 alcoholics classified type 1 and 2 subtypes psychiatric evaluation. random sample 59 social...

Celiac disease (CD) is characterized by villous atrophy with crypt hyperplasia and inflammation of the small intestinal mucosa leading to disturbed epithelial transport. In untreated CD, fat malabsorption can occur. The aim this study was investigate profile serum fatty acids in newly detected CD before after treatment a gluten-free diet.Serum samples were obtained from 50 adults active showing small-bowel mucosal atrophy, same patients remission diet, 59 controls. Serum analyzed capillary...

Iron is essential for body homeostasis, but iron overload may lead to metabolic abnormalities and thus increase the risk atherosclerosis many other diseases. Major histocompatibility complex class I-like transmembrane protein (HFE) involved in metabolism. The gene coding HFE has 3 well-known polymorphic sites of which H63D (rs1799945, C > G) recently been associated with hypertension a genome-wide association study (GWAS) study. In present study, we wanted clarify whether genetic variant...

Avidin is a host acute defense protein induced by progestins and inflammation caused injurious factors such as microbes, viruses, toxic or tissue trauma. In the reproductive tract of egg-laying vertebrates avidin has evolved into progestin-dependent secretory involved in anti-microbial action through its biotin avidity. For "progestin-dependent avidin" production, cellular differentiation estrogen necessary. contrast, expression "progestin-independent inflammation-induced does not require...

Irritable bowel syndrome (IBS) is a fluctuating disorder of the gastrointestinal tract, characterized by abdominal pain and change in habit. We wanted to investigate subjects with IBS for signs disturbed intestinal absorption fatty acids, as reflected serum composition.Serum samples were obtained from 32 adults IBS, 59 controls. Serum acids analyzed capillary gas-liquid chromatography.Especially proportions arachidonic acid (20:4 n-6) long-chain polyunsaturated n-3 family docosapentaenoic...

The activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome by cellular stress leads to the inflammasome, and NLRP3 gene polymorphisms have been associated with autoinflammatory diseases. Inflammasomes also implicated in initiation or progression metabolic disorders such as atherosclerosis, type 2 diabetes obesity. association genetic variant rs7512998 blood pressure hypertension was studied a 50-year-old Finnish cohort subpopulation who had available data on measurements at...

Increased inducible nitric oxide synthase (iNOS) activity and expression has been associated with hypertension, but less is known whether the 2 functional polymorphic sites in iNOS gene (g.-1026 C/A (rs2779249), g.2087 G/A (rs2297518)) affect susceptibility to hypertension. The objective of this study was investigate association between genetic variants diagnosed hypertension a Finnish cohort.This included 320 hypertensive cases 439 healthy controls. All participants were 50-year-old men...

Oxidative stress is involved in the pathophysiology of many cardiovascular disorders, such as hypertension and atherosclerosis. NRF2 primary transcriptional regulator several antioxidant genes, including that sulfiredoxin (SRXN1). The association genotypes SRXN1 with conditions was studied a Finnish cohort 336 subjects diagnosed 480 normotensive controls from Tampere adult population risk study (TAMRISK). Samples were genotyped for four SNPs (rs1962142, rs2706110, rs6721961 rs6706649) gene...

Background. Human fatty acid transporter CD36 gene variations have previously been associated with fat preferences and obesity. These could thus cause overweight hypothetically lead to hypertension. The association of SNP rs1761667 body mass index (BMI) hypertension was therefore studied in a Finnish cohort adults. Methods. data were collected from the Tampere adult population cardiovascular risk study (TAMRISK). A total 314 cases diagnosed hypertension, 422 non-hypertensive healthy controls...