Tanja Zeller
A5046127730- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Genetic Associations and Epidemiology
- Cardiac electrophysiology and arrhythmias
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Blood Pressure and Hypertension Studies
- GDF15 and Related Biomarkers
- Cardiovascular Health and Disease Prevention
- Coronary Interventions and Diagnostics
- Bioinformatics and Genomic Networks
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Fibrosis and Remodeling
- RNA modifications and cancer
- MicroRNA in disease regulation
- Health Systems, Economic Evaluations, Quality of Life
- Diet and metabolism studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Peripheral Artery Disease Management
- Chronic Kidney Disease and Diabetes
Universität Hamburg
2016-2025
University Medical Center Hamburg-Eppendorf
2016-2025
German Centre for Cardiovascular Research
2016-2025
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2009-2025
University of Lübeck
2025
University Hospital Schleswig-Holstein
2025
University of Freiburg
2010-2024
Cardiovascular Research Center
2023-2024
University Medical Center Freiburg
2024
University Cancer Center Hamburg
2019-2024
Cardiac troponin testing is central to the diagnosis of acute myocardial infarction. We evaluated a sensitive I assay for early and risk stratification infarction.In multicenter study, we determined levels as assessed by assay, T, traditional necrosis markers in 1818 consecutive patients with suspected infarction, on admission 3 hours 6 after admission.For samples obtained admission, diagnostic accuracy was highest (area under receiver-operating-characteristic curve [AUC], 0.96), compared T...
Genome-wide association studies have identified numerous loci linked with complex diseases, for which the molecular mechanisms remain largely unclear. Comprehensive profiling of circulating metabolites captures highly heritable traits, can help to uncover metabolic pathophysiology underlying established disease variants. We conduct an extended genome-wide study genetic influences on 123 traits quantified by nuclear magnetic resonance metabolomics from up 24,925 individuals and identify eight...
Background Variability of gene expression in human may link sequence variability and phenotypes; however, non-genetic variations, alone or combination with genetics, also influence traits have a critical role physiological disease processes. Methodology/Principal Findings To get better insight into the overall expression, we assessed transcriptome circulating monocytes, key cell involved immunity-related diseases atherosclerosis, 1,490 unrelated individuals investigated its association...
<h3>Context</h3>Introduction of highly sensitive troponin assays into clinical practice has substantially improved the evaluation patients with chest pain.<h3>Objective</h3>To evaluate diagnostic performance a I (hsTnI) assay compared contemporary (cTnI) and their serial changes in diagnosis acute myocardial infarction (AMI).<h3>Design, Setting, Patients</h3>A total 1818 suspected coronary syndrome were consecutively enrolled at pain units University Heart Center Hamburg, Medical Mainz,...
Exome sequencing studies in complex diseases are challenged by the allelic heterogeneity, large number and modest effect sizes of associated variants on disease risk presence numbers neutral variants, even phenotypically relevant genes. Isolated populations with recent bottlenecks offer advantages for studying rare as they have deleterious that present at higher frequencies well a substantial reduction variation. To explore potential Finnish founder population low-frequency (0.5–5%)...
Atrial fibrillation (AF) is a common cardiac disease in aging populations with high comorbidity and mortality. Sex differences AF epidemiology are insufficiently understood.In N=79 793 individuals without diagnosis at baseline (median age, 49.6 years; age range, 24.1-97.6 51.7% women) from 4 community-based European studies (FINRISK, DanMONICA, Moli-sani Northern Sweden) of the BiomarCaRE consortium (Biomarker for Cardiovascular Risk Assessment Europe), we examined incidence, its association...
Cardiovascular risk estimation by novel biomarkers needs assessment in disease-free population cohorts, followed up for incident cardiovascular events, assaying the serum and plasma archived at baseline. We report results from 2 cohorts such a continuing study.Thirty different pathophysiological pathways were evaluated 7915 men women of FINRISK97 cohort with 538 events 10 years (fatal or nonfatal coronary stroke events), which biomarker score was developed then validated 2551 Belfast...
Dilated cardiomyopathy (DCM) is a major cause of heart failure with high familial recurrence risk. So far, the genetics DCM remains largely unresolved. We conducted first genome-wide association study (GWAS) to identify loci contributing sporadic DCM. One thousand one hundred and seventy-nine patients 1108 controls contributed discovery phase. Pools DNA stratified on disease status, population, age, gender were constituted used for testing 517 382 single nucleotide polymorphisms (SNPs)....
Oxidative stress is causally linked to the progression of heart failure, and mitochondria are critical sources reactive oxygen species in failing myocardium. We previously observed that elevated cytosolic Na(+) ([Na(+)](i)) reduces mitochondrial Ca(2+) ([Ca(2+)](m)) by accelerating efflux via Na(+)/Ca(2+) exchanger. Because regeneration antioxidative enzymes requires NADPH, which indirectly regenerated Krebs cycle, cycle dehydrogenases activated [Ca(2+)](m), we speculated myocytes,...
Background Increased adiposity is linked with higher risk for cardiometabolic diseases. We aimed to determine what extent elevated body mass index (BMI) within the normal weight range has causal effects on detailed systemic metabolite profile in early adulthood. Methods and Findings used Mendelian randomization estimate of BMI 82 metabolic measures 12,664 adolescents young adults from four population-based cohorts Finland (mean age 26 y, 16–39 y; 51% women; mean ± standard deviation 24±4...
Data regarding high-sensitivity troponin concentrations in patients presenting to the emergency department with symptoms suggestive of myocardial infarction may be useful determining probability and subsequent 30-day outcomes.
Our aims were to evaluate the distribution of troponin I concentrations in population cohorts across Europe, characterize association with cardiovascular outcomes, determine predictive value beyond variables used ESC SCORE, test a potentially clinically relevant cut-off value, and improved eligibility for statin therapy based on elevated retrospectively.Based Biomarkers Cardiovascular Risk Assessment Europe (BiomarCaRE) project, we analysed individual level data from 10 prospective...