A5048078193- Acute Myocardial Infarction Research
- Lipoproteins and Cardiovascular Health
- Migration, Health and Trauma
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Health and Medical Studies
- Birth, Development, and Health
- Health disparities and outcomes
- Diabetes Management and Research
- Cardiac Imaging and Diagnostics
- Diabetes Treatment and Management
- Pregnancy and preeclampsia studies
- Chronic Disease Management Strategies
- Cardiac electrophysiology and arrhythmias
- Child and Adolescent Health
- Behavioral Health and Interventions
- Maternal and Perinatal Health Interventions
- Health and Conflict Studies
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Pediatric health and respiratory diseases
- Health Systems, Economic Evaluations, Quality of Life
- Human Health and Disease
- Social and Demographic Issues in Germany
- Gestational Diabetes Research and Management
- Retirement, Disability, and Employment
Universität Hamburg
2016-2024
University Medical Center Hamburg-Eppendorf
2016-2024
German Centre for Cardiovascular Research
2016-2024
Leibniz Institute for Prevention Research and Epidemiology - BIPS
2012-2016
Leibniz Association
2015
University of Bremen
2012
Our aims were to evaluate the distribution of troponin I concentrations in population cohorts across Europe, characterize association with cardiovascular outcomes, determine predictive value beyond variables used ESC SCORE, test a potentially clinically relevant cut-off value, and improved eligibility for statin therapy based on elevated retrospectively.Based Biomarkers Cardiovascular Risk Assessment Europe (BiomarCaRE) project, we analysed individual level data from 10 prospective...
BackgroundThe relevance of blood lipid concentrations to long-term incidence cardiovascular disease and the lipid-lowering therapy for outcomes is unclear. We investigated risk associated with full spectrum bloodstream non-HDL cholesterol concentrations. also created an easy-to-use tool estimate probabilities a event modelled its reduction by treatment.MethodsIn this risk-evaluation risk-modelling study, we used Multinational Cardiovascular Risk Consortium data from 19 countries across...
Rapid and accurate diagnosis of acute myocardial infarction (AMI) currently constitutes an unmet need.To test a 1-hour diagnostic algorithm to diagnose AMI using high-sensitivity troponin I assay with new cutoff level 6 ng/L.The Biomarkers in Acute Cardiac Care study is prospective that investigated the application for 1040 patients presenting emergency department chest pain from July 19, 2013, December 31, 2014. Results were validated 2 independent cohorts 4009 patients. Final follow-up was...
As promising compounds to lower Lipoprotein(a) (Lp(a)) are emerging, the need for a precise characterization and comparability of Lp(a)-associated cardiovascular risk is increasing. Therefore, we aimed evaluate distribution Lp(a) concentrations across European population, characterize association with outcomes provide high by use centrally determined concentrations.
Abstract AIMS Serial measurements of high-sensitivity troponin are used to rule out acute myocardial infarction (AMI) with an assay specific cutoff at the 99th percentile. Here, we evaluated performance a single admission lower combined low risk electrocardiogram (ECG) AMI. METHODS Troponin I measured (hs-TnI) was determined in 1040 patients presenting suspected AMI (BACC study). To calculated negative predictive value (NPV) utilizing optimal hs-TnI ECG. The results were validated 3566 [2-h...
Abstract Background Biomarkers may contribute to improved cardiovascular risk estimation. Glycated hemoglobin A 1c (HbA ) is used monitor the quality of diabetes treatment. Its strength association with outcomes in general population remains uncertain. This study aims assess HbA population. Methods Data from six prospective population-based cohort studies across Europe comprising 36,180 participants were analyzed. was evaluated conjunction classical factors (CVRFs) for mortality, disease...
The aims of this study were to characterize the association high-sensitivity cardiac troponin I (hs-cTnI) with heart failure (HF), determine its predictive value beyond classical cardiovascular risk factors (CVRFs) and N-terminal pro-B-type natriuretic peptide, derive a relevant cutoff for potential clinical application.HF is an important contributor overall burden disease. Early identification individuals at could be beneficial preventive therapies.Based on Biomarker Cardiovascular Risk...
Abstract Background A healthy nutrition in pregnancy supports maternal health and fetal development, decreasing the risk for adverse outcomes. Guidance by prenatal care professionals can increase women’s awareness regarding importance of thereby contribute to a reduced The aim this study was assess needs, wishes preferences pregnant women interprofessional guidance on pregnancy. Methods Using qualitative approach purposive maximum variation sampling strategy, 25 were recruited participate...
A relationship between lifestyle, diet, and atrial fibrillation (AF) remains unclear. Except for alcohol consumption, AF guidelines do not differentiate specific advice this rhythm disorder. The aim of study was to investigate the association adherence healthy dietary patterns presence AF, among 104 low risk participants from 1:1 matched case-control AFHRI (Atrial Fibrillation in High-Risk Individuals) study. Dietary data were obtained using a three-day food record. Adapted German versions...
Midwifery services play an important role in healthcare provision, birth preparation and prevention.Knowledge on women's expectations, preferences needs regarding midwifery care is crucial not only for clinical during preconception pregnancy research, but also educational purposes. This descriptive qualitative study aimed to investigate the of women concerning Germany.Experienced researcher team conducted interviews with who have desire get pregnant online focus groups early late pregnancy....
In 2009, 19.6% of the population Germany either had migrated themselves or were offspring people with migration experience. Migrants differ from autochthonous German in terms health status, awareness and behaviour. To further investigate situation migrants Germany, epidemiological studies are needed. Such can employ existing databases which provide detailed information on status. Otherwise, onomastic toponomastic procedures be applied to identify background. If have recruited into an study,...
Dietary and social behaviour are non-medical factors that influence health outcomes. Non-communicable diseases related to dietary patterns. To date, little is known about how associated with health-related patterns, and, in particular, we lack information the role of sex within this possible relation. Our cross-sectional study investigated associations between patterns including personality traits (self-control, risk taking), political preferences (conservative, liberal, ecological, social)...
High-sensitivity troponin has proven to be a promising biomarker for the prediction of future adverse cardiovascular events. We aimed assess prognostic value high-sensitivity I (hs-TnI) on admission in patients with suspected acute myocardial infarction (AMI) analyzed by novel (Singulex Clarity cTnI) and established hs-TnI assay (ARCHITECT STAT hs-TnI, Abbott). Hs-TnI was measured total 2332 from two prospective cohort studies presenting emergency department AMI. The impact overall mortality...
The main goals of our study were (I) the investigation expectations and preferences as well (II) determination needs women in regard to midwifery care. Descriptive phenomenology was used investigate ways which experienced childbirth early parenthood. A descriptive qualitative research design chosen, using focus groups. ix online groups carried out with 19 for this part Midwifery Care (MiCa) study, mainly from north Germany. Women shortly after birth, puerperium first year recruited...
Abstract Background Prostate cancer (PCa) is the most frequently diagnosed malignant tumor in men. The potential benefit of a healthy lifestyle contrasts sharply with observed poor adherence to current international guidelines. Thus, well‐designed sustainable interventions aftercare that can be translated into routine practice are highly recommended. present pilot study aimed evaluate feasibility and acceptability multimodal intervention program PCa patients after radical prostatectomy (RP)....
Objectives The main objective of this study was to explore differences in mortality patterns among two large immigrant groups Germany: one from Turkey and the other former Soviet Union (FSU). To end, we investigated indicators premature mortality. Design This conducted as a retrospective population-based based on register linkage. Using data for period 2004–2010, calculated age-standardised death rates (SDR) standardised ratios (SMR) deaths (<age 65 years). We computed years potential...
Abstract European populations are changing fast (Rechel B, Mladovsky P, Ingleby D, Mackenbach JP, McKee M. Migration and health in an increasingly diverse Europe. Lancet 2013;381:1235–45). Social categories such as ethnicity, migration background, country of origin, socio-economic status gender exist alongside each other but need to be considered jointly order better capture the ever increasing complexity communities their inhabitants. In last decade, concept “superdiversity” (Vertovec S....
This population-based cross-sectional cohort study investigated the association of Mediterranean and DASH (Dietary Approach to Stop Hypertension) diet as well supplement intake with gray-scale median (GSM) presence carotid plaques comparing women men. Low GSM is associated plaque vulnerability. Ten thousand participants Hamburg City Health Study aged 45–74 underwent ultrasound examination. We analyzed in all plus those having (n = 2163). Dietary patterns were assessed via a food frequency...
Abstract Background Poor oral and dental health due to dysbiosis during pregnancy increases the risk for negative outcomes. Communicating importance of is therefore essential in reducing adverse Professional guidance could substantially support women’s positive perception their own competence. Information on should be provided by healthcare professionals such as midwives, obstetricians dentists. The aim this study was assess needs, wishes preferences pregnant women Germany, regarding...