A5047746080- Acute Ischemic Stroke Management
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Stroke Rehabilitation and Recovery
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Machine Learning in Healthcare
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Dementia and Cognitive Impairment Research
- Neurological Disorders and Treatments
- Peripheral Artery Disease Management
- Clinical practice guidelines implementation
- Cardiac, Anesthesia and Surgical Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Health and Risk Factors
- Advanced MRI Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Neurological and metabolic disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Circadian rhythm and melatonin
- Dental Health and Care Utilization
- Cardiac Health and Mental Health
- Health, Environment, Cognitive Aging
- Health Promotion and Cardiovascular Prevention
University Medical Center Hamburg-Eppendorf
2014-2025
Universität Hamburg
2014-2025
Luzerner Kantonsspital
2024-2025
Eppendorf (Germany)
2022
Klinik und Poliklinik für Neurologie
2017-2022
Long-term sequelae may occur after SARS-CoV-2 infection. We comprehensively assessed organ-specific functions in individuals mild to moderate infection compared with controls from the general population.Four hundred and forty-three mainly non-hospitalized were examined median 9.6 months first positive test matched for age, sex, education 1328 a population-based German cohort. pulmonary, cardiac, vascular, renal, neurological status, as well patient-related outcomes. Bodyplethysmography...
There is a paucity of current figures on the prevalence carotid and lower extremity peripheral arterial disease (PAD) abdominal aortic aneurysm (AAA) as well associated cardiovascular risk factors to support considerations screening programmes.In population based Hamburg City Health Study, participants between 45 74 years were randomly recruited. In cross sectional analysis first 10 000 enrolled February 2016 November 2018, artery (intima-media thickness ≥ 1 mm), PAD (ankle brachial index ≤...
Age-related cortical atrophy, approximated by thickness measurements from magnetic resonance imaging, follows a characteristic pattern over the lifespan. Although its determinants remain unknown, mounting evidence demonstrates correspondence between connectivity profiles of structural and functional brain networks atrophy in health neurological disease. Here, we performed cross-sectional multimodal neuroimaging analysis 2633 individuals large population-based cohort to characterize...
Abstract Background Implementation of interventions to improve follow-up stroke care is complex due the involvement various stakeholders and challenges health coordination. The aim this study was evaluate process implementing a cross-sectoral, coordinated for patients (the StroCare intervention). Methods As part multicenter interventional trial, qualitative performed in pre-post design with semi-structured interviews conducted employees. multicomponent intervention implemented eight...
We aimed to assess impairments on health-related quality of life, and mental health resulting from Retinal artery occlusion (RAO) with monocular visual field loss posterior circulation ischemic stroke (PCIS) full or partial hemianopia using patient-reported outcome measures (PROMs). In a prospective study, consecutive patients acute RAO fundoscopy PCIS imaging were recruited during their surveillance unit over period 15 months. Baseline characteristics determined medical records interviews....
Stroke survivors experience physical and psychological symptoms. However, long-term symptom prevalence associations have not been extensively studied. The current study aimed to assess the of symptoms across four years after stroke evaluate relationship between these We conducted a secondary analysis prospective, clinical, observational study. Physical (pain, fatigue, impairment) (loss interest, depressed mood, anxiety, worry) were assessed using International Consortium for Health Outcomes...
Abstract Background Previous epidemiological studies regarding the association between chronic periodontitis (CP) and carotid intima‐media thickness (cIMT) subclinical atherosclerosis have been inconclusive. Objective The aim of this study was to determine whether CP is associated with in a large population‐based cohort conducted northern Germany (the Hamburg City Health study). Methods Baseline data from 5781 participants Study complete oral health ultrasound (50.7% female, mean age: 62.1 ±...
Background and purpose Stroke has detrimental effects in multiple health domains not captured by routine scales. The International Consortium for Health Outcome Measurement developed a standardized set self‐reported assessment to overcome this limitation. aim was assess acute stroke care. Methods Consecutive patients with ischaemic stroke, transient attack or intracerebral hemorrhage were enrolled. Demographics, living situation cardiovascular risk factors collected from medical records...
Abstract Introduction The impact of stroke-related impairment on activities daily living may vary between patients, and can only be estimated by applying patient-reported outcome measures. International Consortium for Health Outcome Measurement has developed a standard set instruments that combine clinical longitudinal measures stroke. present study was designed (1) to implement evaluate the feasibility use it as consistent measure in routine at stroke center German university hospital, (2)...
Background Determining the discharge destination after acute stroke care is important to prevent long-term disabilities and improve cost efficiency. Objective The aim of this study was investigate where patients are discharged treatment identify personal, social, stroke-related, clinical predictors destination. Methods present included a secondary exploratory analysis prospective observational study. Patients with ischemic stroke, transient attack, or intracerebral hemorrhage were recruited...
Background and Purpose- Tractography by diffusion tensor imaging has extended our knowledge on the contribution of damage to different pathways residual motor function after stroke. Integrity corticospinal tract (CST), for example, been identified characterize predict its course. Yet there is only scarce data that allow a judgment impact extrapyramidal between basal ganglia poststroke. We aimed at studying their association with performance in fine skills Methods- performed probabilistic...
Abstract Introduction Stroke has a long-term impact on functional status and quality of life in multiple health domains. A well-coordinated managed care program for stroke patients is crucial ameliorating patients’ cost-efficient use resources. The aim this study the implementation evaluation an optimised cross-sectoral, coordinated bridging secondary tertiary care. Methods In multi-center mixed method sequentially controlled intervention study, with ischemic (I63), transient attack related...
Abstract Purpose Comorbidities and polypharmacy are risk factors for worse outcome in stroke. However, comorbidities mostly studied separately with various approaches to assess them. We aimed analyze the impact of comorbidity burden on functional acute ischemic stroke (AIS) patients undergoing mechanical thrombectomy (MT). Methods Acute large vessel occlusion (LVO) treated MT from a prospective observational study were analyzed. Relevant was defined as Charlson Comorbidity Index (CCI) score...
Acute ischaemic stroke (AIS) after percutaneous coronary intervention (PCI) is a rare, but debilitating, complication. However, contemporary data from real-world unselected patients are scarce.
Abstract Background We aimed to identify groups of patients with similar health status after stroke, assessed by patient reported outcome measures (PROMs), improve initial risk stratification. Methods In a prospective study, inpatients were recruited during acute stroke treatment. Demographics, history, and cardio-vascular factors at baseline. Self-reported functional status, physical mental as well anxiety depressive symptoms 3 12 months used latent classes. The association characteristics...
Abstract Background Patient-reported outcome measures (PROMs) assess patient-relevant effects of medical treatments. We aimed to evaluate the implementation International Consortium for Health Outcomes Measurement Standard Set Stroke (ICHOM-SSS) into routine inpatient care a stroke unit. Methods The ICHOM-SSS was administered in certified unit during and after care. Semi-structured interviews with staff ( n = 5) patients or their proxies 19) about experience were audio-recorded analysed...
It is uncertain whether there an association of carotid plaques (CPs) and flow velocities with peak width mean diffusivity (PSMD) white matter hyperintensities (WMH) independent shared risk factors. We aimed to study this controlling for biomarkers inflammation cardiac dysfunction typical cardiovascular factors spatial distribution.We included participants from the population-based Hamburg City Health Study, recruiting citizens between 45 74 years age. Medical history was obtained structured...
Abstract The inflammatory burden as measured by high-sensitivity C-reactive Protein (hsCRP) is recognized a cardiovascular risk factor, which can however be affected lifestyle-related factors (LRF). Up-to-date the interplay between hsCRP, LRF and presence extent of atherosclerotic disease still largely unknown, we therefore sought to investigate in contemporary population-based cohort. We included participants from cross-sectional Hamburg City Health Study. Affected vascular beds were...
To describe our experience with consensus-based decision-making for treatment of internal carotid artery (ICA) stenosis by neurologists, interventional neuroradiologists, vascular surgeons, and neurosurgeons in a multidisciplinary neurovascular board to study adherence recommendations the context uncertainty respect best option.We established meeting twice week structured documentation consensus decisions. Over time period 53 months, 614 cases ICA were discussed, 285 (46%) symptomatic 279...
This population-based cross-sectional cohort study investigated the association of Mediterranean and DASH (Dietary Approach to Stop Hypertension) diet as well supplement intake with gray-scale median (GSM) presence carotid plaques comparing women men. Low GSM is associated plaque vulnerability. Ten thousand participants Hamburg City Health Study aged 45–74 underwent ultrasound examination. We analyzed in all plus those having (n = 2163). Dietary patterns were assessed via a food frequency...