A5077262901- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Genetic Associations and Epidemiology
- Cancer-related gene regulation
- Oral microbiology and periodontitis research
- Diet and metabolism studies
- Gut microbiota and health
- Endometriosis Research and Treatment
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Lipoproteins and Cardiovascular Health
- Bioinformatics and Genomic Networks
- Diabetes Treatment and Management
- Nutritional Studies and Diet
- Reproductive System and Pregnancy
- Cardiovascular Health and Disease Prevention
- Infective Endocarditis Diagnosis and Management
- Cardiac Health and Mental Health
- Blood Pressure and Hypertension Studies
- S100 Proteins and Annexins
- Parkinson's Disease Mechanisms and Treatments
- Inflammatory mediators and NSAID effects
- Cardiac Fibrosis and Remodeling
University Medical Center Hamburg-Eppendorf
2018-2024
German Centre for Cardiovascular Research
2020-2024
Universität Hamburg
2018-2023
Martini-Klinik
2020
University Hospital Münster
2020
Atrial fibrillation (AF) is an important heart rhythm disorder in aging populations. The gut microbiome composition has been previously related to cardiovascular disease risk factors. Whether the microbial profile also associated with of AF remains unknown.We examined associations prevalent and incident microbiota FINRISK 2002 study, a random population sample 6763 individuals. We replicated our findings independent case-control cohort 138 individuals Hamburg, Germany.Multivariable-adjusted...
The aims of this study were to characterize the association high-sensitivity cardiac troponin I (hs-cTnI) with heart failure (HF), determine its predictive value beyond classical cardiovascular risk factors (CVRFs) and N-terminal pro-B-type natriuretic peptide, derive a relevant cutoff for potential clinical application.HF is an important contributor overall burden disease. Early identification individuals at could be beneficial preventive therapies.Based on Biomarker Cardiovascular Risk...
Abstract Genome-wide association studies (GWAS) for atrial fibrillation (AF) have uncovered numerous disease-associated variants. Their underlying molecular mechanisms, especially consequences mRNA and protein expression remain largely elusive. Thus, refined multi-omics approaches are needed deciphering the networks. Here, we integrate genomics, transcriptomics, proteomics of human tissue in a cross-sectional study to identify widespread effects genetic variants on both transcript ( cis...
To identify robust circulating predictors for incident atrial fibrillation (AF) using classical regressions and machine learning (ML) techniques within a broad spectrum of candidate variables.In pooled European community cohorts (n = 42 280 individuals), 14 routinely available biomarkers mirroring distinct pathophysiological pathways including lipids, inflammation, renal, myocardium-specific markers (N-terminal pro B-type natriuretic peptide [NT-proBNP], high-sensitivity troponin I [hsTnI])...
A relationship between lifestyle, diet, and atrial fibrillation (AF) remains unclear. Except for alcohol consumption, AF guidelines do not differentiate specific advice this rhythm disorder. The aim of study was to investigate the association adherence healthy dietary patterns presence AF, among 104 low risk participants from 1:1 matched case-control AFHRI (Atrial Fibrillation in High-Risk Individuals) study. Dietary data were obtained using a three-day food record. Adapted German versions...
Objective Atrial fibrillation (AF) has emerged as a common condition in older adults. Cardiovascular risk factors only explain about 50% of AF cases. Inflammatory biomarkers may help close this gap inflammation can alter atrial electrophysiology and structure. This study aimed to determine cytokine biomarker profile for the community using proteomics approach. Methods uses participants Finnish population-based FINRISK cohort studies 1997/2002. Risk models 46 cytokines were developed predict...
Abstract Aims Classical cardiovascular risk factors (CVRFs), biomarkers, and common genetic variation have been suggested for assessment of atrial fibrillation (AF). To evaluate their clinical potential, we analysed individual combined ability AF prediction. Methods results In N = 6945 individuals the FINRISK 1997 cohort, assessed predictive value CVRF, N-terminal pro B-type natriuretic peptide (NT-proBNP), 145 recently identified single-nucleotide polymorphisms (SNPs) in a developed...
Background Although myocardial infarction (MI) and atrial fibrillation (AF) are frequent comorbidities share common cardiovascular risk factors, the direction strength of association factors with disease onset, subsequent incidence, mortality not completely understood. Methods Results In pooled multivariable Cox regression analyses, we examined temporal relations onset identified predictors MI, AF, all-cause in 108 363 individuals (median age, 46.0 years; 48.2% men) free MI AF at baseline...
Background/Aim Atrial fibrillation (AF) is a major health problem and causes heart failure stroke. Pathophysiological mechanisms indicate link with oral including periodontitis (PD), but supporting data are scarce. The aim was to investigate the between features of prevalence AF. Methods This cross-sectional analysis Hamburg City Health Study included 5,634 participants complete on their PD AF status. assessed via self-reported questionnaire or medically diagnosed by standard 12-lead resting...
Natriuretic peptides are extensively studied biomarkers for atrial fibrillation (AF) and heart failure (HF). Their role in the pathogenesis of both diseases is not entirely understood previous studies several single-nucleotide polymorphisms (SNPs) at NPPA-NPPB locus associated with natriuretic have been identified. We investigated causal relationship between AF as well HF using a Mendelian randomization approach.N-terminal pro B-type peptide (NT-proBNP) (N = 6669), (BNP) 6674), mid-regional...
Background and Aims The relationship between postoperative atrial fibrillation (POAF) 25-hydroxyvitamin D [25(OH)D] concentration as well vitamin supplementation has been discussed controversially. relation of pre-operative status POAF remains unclear. Methods Results We analysed the risk in a prospective, observational cohort study n = 201 patients undergoing coronary artery bypass graft surgery (CABG) with 25(OH)D concentration. median age was 66.6 years, 15.4% were women. (25th/75th...
Downregulated microRNA-142-3p signaling contributes to the pathogenesis of endometriosis, an invasive disease where lining uterus grows at ectopic locations, by yet incompletely understood mechanisms. Using bioinformatics and in vitro assays, this study identifies cytoskeletal regulation integrin as two relevant categories miR-142-3p targets. qPCR revealed that upregulation St-T1b cells downregulates Rho-associated protein kinase 2 (ROCK2), cofilin (CFL2), Ras-related C3 botulinum toxin...
Arterial stiffness is a strong predictor of atrial fibrillation in the community. Whether noninvasively measured conduit artery function and peripheral vascular reactivity are related to remains unknown. In 15 010 individuals population-based Gutenberg Health Study, mean age 55 ± 11 years, 50.5% men, we determined noninvasive by flow-mediated dilation (FMD) arterial tonometry (PAT) relation manifest (N = 466). Patients with exhibited higher brachial diameter [4.81 mm (4.17, 5.33) vs. 4.31...
Stroke is a common cause of death and leading disability morbidity. risk assessment remains challenge, but circulating biomarkers may improve prediction. Controversial evidence available on the predictive ability troponin concentrations stroke in community. Furthermore, reports value for different subtypes are scarce.High-sensitivity cardiac I (hsTnI) were assessed 82 881 individuals (median age, 50.7 years; 49.7% men) free or myocardial infarction at baseline from 9 prospective European...
Abstract Aim of this study was to investigate the association between periodontitis and arterial hypertension, both which show correlations with classical cardiovascular risk factors inflammatory activity. Materials methods A cross-sectional analysis data from a large population-based health survey (the Hamburg City Health Study, HCHS) including 5934 participants complete periodontal examination blood pressure data, whom 5735 had medical records regarding anti-hypertensive medication,...
Abstract Background Atrial fibrillation is associated with cognitive dysfunction. cardiomyopathy has been correlated both entities. We aimed to characterize the association of echocardiographic parameters atrial function and cerebral changes. Methods Participants population-based Hamburg City Health Study underwent in-depth transthoracic echocardiography testing, Animal Naming Test (ANT), Trail Making A (TMT-A) B (TMT-B), 10-word learning test magnetic resonance imaging. Results After...
Downregulated microRNA-142-3p signaling contributes to the pathogenesis of endometriosis [1] [2], an invasive disease where lining uterus grows at ectopic locations, by yet incompletely understood mechanisms. Using bioinformatics and in vitro assays, this study identifies cytoskeletal regulation integrin as two relevant categories miR-142-3p targets. qPCR revealed that upregulation St-T1b cells downregulates ROCK2, CFL2, RAC1, WASL ITGAV. Western-blotting showed effect on ITGAV was...
Atrial fibrillation (AF) is becoming increasingly common. Traditional cardiovascular risk factors (CVRF) do not explain all AF cases. Blood-based biomarkers reflecting cardiac injury such as high-sensitivity troponin I (hsTnI) may help close this gap.
Abstract Genome-wide association studies (GWAS) for atrial fibrillation (AF) have uncovered numerous disease-associated variants. Their underlying molecular mechanisms, especially consequences mRNA and protein expression remain largely elusive. Thus, novel multiOMICs approaches are needed deciphering the networks. Here, we integrated genomics, transcriptomics, proteomics of human tissue which allowed identifying widespread effects genetic variants on both transcript (cis eQTL) pQTL)...