A5057417339- Diet and metabolism studies
- Gut microbiota and health
- Nutritional Studies and Diet
- Eicosanoids and Hypertension Pharmacology
- Liver Disease Diagnosis and Treatment
- Cardiac Health and Mental Health
- Fatty Acid Research and Health
- Hormonal Regulation and Hypertension
- Food Security and Health in Diverse Populations
- Cardiac, Anesthesia and Surgical Outcomes
- Genetic Associations and Epidemiology
- Diet, Metabolism, and Disease
- Acute Myocardial Infarction Research
- Nonlinear Photonic Systems
- Heart Failure Treatment and Management
- Alcohol Consumption and Health Effects
- Cardiac Imaging and Diagnostics
- Topological Materials and Phenomena
- Cardiovascular Disease and Adiposity
- Nutrition, Genetics, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Parkinson's Disease Mechanisms and Treatments
- Lipoproteins and Cardiovascular Health
- Health, Environment, Cognitive Aging
- Diabetes, Cardiovascular Risks, and Lipoproteins
University of Turku
2012-2024
Finnish Institute for Health and Welfare
2019-2023
Turku University Hospital
2019-2023
University of Leeds
2011
Background Several small-scale animal studies have suggested that gut microbiota and blood pressure (BP) are linked. However, results from human remain scarce conflicting. We wanted to elucidate the multivariable-adjusted association between metagenome BP in a large, representative, well-phenotyped population sample. performed focused analysis examine previously reported inverse associations sodium intake Lactobacillus abundance BP. Methods Results studied sample of 6953 Finns aged 25 74...
Diet has a major influence on the human gut microbiota, which been linked to health and disease. However, epidemiological studies associations of healthy diet with microbiota utilizing whole-diet approach are still scant.
Atrial fibrillation (AF) is an important heart rhythm disorder in aging populations. The gut microbiome composition has been previously related to cardiovascular disease risk factors. Whether the microbial profile also associated with of AF remains unknown.We examined associations prevalent and incident microbiota FINRISK 2002 study, a random population sample 6763 individuals. We replicated our findings independent case-control cohort 138 individuals Hamburg, Germany.Multivariable-adjusted...
Background Epidemiological and animal studies have associated systemic inflammation with blood pressure (BP). However, the mechanistic factors linking BP remain unknown. Fatty acid-derived eicosanoids serve as mediators of been suggested to regulate renal vascular tone, peripheral resistance, renin-angiotensin system, endothelial function. We hypothesize that specific proinflammatory anti-inflammatory are linked BP. Methods Results studied a population sample 8099 FINRISK 2002 participants...
Previous studies on the association between metabolic biomarkers and hypertension have been limited by small sample sizes, low number of studied biomarkers, cross-sectional study design. In largest to date, we assess longitudinal associations high-abundance serum blood pressure (BP).We (N = 36 985; age 50.5 ± 14.2; 53.1% women) 4197; 49.4 11.8, 55.3% population samples Finnish individuals. We included 53 other detailed lipoprotein subclass measures in our analyses. BP using both conventional...
Several materials, such as ferromagnets, spinor Bose-Einstein condensates, and some topological insulators, are now believed to support knotted structures. One of the most successful base-models having stable knots is Faddeev-Skyrme model it expected be contained in these experimentally relevant models. The taxonomy solitons (Hopfions) this known. In paper we describe aspects dynamics Hopfions show that they do indeed behave like particles: during scattering Hopf charge conserved bound...
Abstract The primary cellular substrates of atrial fibrillation (AF) and the mechanisms underlying AF onset remain poorly characterized therefore, its risk assessment lacks precision. While use omics may enable discovery novel factors narrow down pathways involved in pathogenesis, work is far from complete. Large-scale genome-wide association studies transcriptomic analyses that allow an unbiased, non-candidate-gene-based delineation molecular changes associated with humans have identified...
Background and Objective: Our goal was to examine the previously unknown long-term association between gut microbiome composition incident hypertension in a representative population cohort. Methods: We collected fecal samples from sample of 3,055 non-hypertensive Finns (mean age 43.1 years; 60.8% women) 2002. These individuals were followed up for until 31 December 2021 using nationwide register data. The sequenced shotgun metagenomics. examined associations Cox regression (alpha diversity...
Coronary artery bypass grafting (CABG) is associated with both cardiovascular disease (CVD) and non-CVD traits. In addition, women's prognosis after coronary events revascularizations worse than in men. As the course of CVD women differs from that men, we performed a phenome-wide analysis on sex differences CABG -related morbidity mortality.We an untargeted predictors outcomes CABG. We studied sample 176,680 FinnGen participants, including 5,950 individuals who underwent (4,988 men 962...
Abstract Background Parkinson’s disease (PD) is a neurodegenerative movement disorder with mainly unknown etiology. Constipation common symptom, and changes in gut microbiota may play role PD pathogenesis. Previous studies exploring microbial associations to have been mostly cross-sectional, the of microorganisms etiology remains unclear. Thus, we examined association between features incident prospective cohort design. Methods In FINRISK 2002 Study, 7231 participants gave stool sample that...
To perform an untargeted data-driven analysis on the correlates and outcomes of coronary artery bypass grafting (CABG).FinnGen cohort study.The authors collected information up to 1,327 disease traits before after CABG from nationwide healthcare registers.A mixed population patient sample 127,911 individuals including 3,784 patients.The assessed association between (1) incident (2) using multivariate-adjusted Cox models.Patients who underwent were in fourth quartile a risk score based top...
ABSTRACT Aim Peptide markers of inflammation have been associated with the development type 2 diabetes. The role upstream, lipid-derived mediators such as eicosanoids, remains less clear. aim was to examine whether eicosanoids are incident Methods In FINRISK 2002 study, a population-based sample Finnish men and women aged 25-74 years, we used directed, non-targeted liquid chromatography – mass spectrometry identify 545 related oxylipins in participants’ plasma samples (n=8,292). We...
We study a modified version of the Ginzburg-Landau model suggested by Ward and show that Hopfions exist in it as stable static solutions, for values Hopf invariant up to at least 7. also find their properties closely follow those counterparts Faddeev-Skyrme model. Finally, we lend support Babaev's conjecture longer core lengths yield more solitons propose possible mechanism constructing pure
Abstract Epidemiological and animal studies have associated systemic inflammation with blood pressure (BP). However, the mechanistic factors linking BP remain unknown. Fatty acid derived eicosanoids serve as mediators of been suggested to also regulate renal vascular tone, peripheral resistance, renin-angiotensin system, endothelial function. We therefore hypothesize that specific pro- anti-inflammatory are linked BP. studied a population sample 8099 FINRISK 2002 participants randomly drawn...