A5011112541- Gut microbiota and health
- Microbial Community Ecology and Physiology
- Liver Disease Diagnosis and Treatment
- Polar Research and Ecology
- Mercury impact and mitigation studies
- Clostridium difficile and Clostridium perfringens research
- Nutritional Studies and Diet
- Climate change and permafrost
- Food Security and Health in Diverse Populations
- Genomics and Phylogenetic Studies
- Diabetes Management and Education
- Pharmaceutical and Antibiotic Environmental Impacts
- Diet and metabolism studies
- Environmental DNA in Biodiversity Studies
- Epigenetics and DNA Methylation
- Antibiotic Resistance in Bacteria
- Methane Hydrates and Related Phenomena
- Nutrition and Health in Aging
- Nutrition, Genetics, and Disease
- Health, Environment, Cognitive Aging
- Indoor Air Quality and Microbial Exposure
- Dermatology and Skin Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Heavy Metal Exposure and Toxicity
- Folate and B Vitamins Research
University of Turku
2020-2024
Finnish Institute for Health and Welfare
2020-2024
Turku University Hospital
2020-2021
University of Ottawa
2017-2020
University of Helsinki
2015
To examine the previously unknown long-term association between gut microbiome composition and incident type 2 diabetes in a representative population cohort.We collected fecal samples from 5,572 Finns (mean age 48.7 years; 54.1% women) 2002 who were followed up for until 31 December 2017. The sequenced using shotgun metagenomics. We examined associations multivariable-adjusted Cox regression models. first used eastern Finland subpopulation to obtain initial findings validated these western...
Diet has a major influence on the human gut microbiota, which been linked to health and disease. However, epidemiological studies associations of healthy diet with microbiota utilizing whole-diet approach are still scant.
Fatty liver disease is the most common in world. Its connection with gut microbiome has been known for at least 80 y, but this association remains mostly unstudied general population because of underdiagnosis and small sample sizes. To address knowledge gap, we studied link between Liver Index (FLI), a well-established proxy fatty disease, composition representative, ethnically homogeneous 6,269 Finnish participants. We based our models on biometric covariates compositions from shallow...
The gut microbiome has shown promise as a predictive biomarker for various diseases. However, the potential of microbiota prospective risk prediction liver disease not been assessed. Here, we utilized shallow shotgun metagenomic sequencing large population-based cohort (N > 7,000) with ∼15 years follow-up in combination machine learning to investigate capacity microbial predictors individually and conjunction conventional factors incident disease. Separately, showed comparable capacity....
The dissemination of antibiotic resistance genes to the environment is an important factor causing increased prevalence resistant pathogens. Manure fertilizer, but it contains diverse genes. Therefore, its application fields may lead abundance in environment. Farming environments exposed animal manure have not been studied extensively countries with comparably low use, such as Finland. effects storage and on were two dairy cattle farms swine southern Samples taken from during 2013 cropping...
The Arctic is undergoing rapid environmental change, potentially affecting the physicochemical constraints of microbial communities that play a large role in both carbon and nutrient cycling lacustrine environments. However, such environments have seldom been studied, drivers their composition are poorly characterized. To address these gaps, we surveyed biologically active surface sediments Lake Hazen, largest lake by volume north Circle, small shoreline pond its watershed. High-throughput...
Abstract Multiomics has shown promise in noninvasive risk profiling and early detection of various common diseases. In the present study, a prospective population-based cohort with ~18 years e-health record follow-up, we investigated incremental combined value genomic gut metagenomic assessment compared conventional factors for predicting incident coronary artery disease (CAD), type 2 diabetes (T2D), Alzheimer prostate cancer. We found that polygenic scores (PRSs) improved prediction over...
Mercury (Hg) bioavailability to bacteria in marine systems is the first step toward its bioamplification food webs. These exhibit high salinity and ionic strength that will both alter Hg speciation properties of cell walls. The role on has not been teased apart from wall properties, however. We developed optimized a whole-cell bioreporter capable functioning under aerobic anaerobic conditions exhibiting no physiological limitations signal production changes strength. show controls species,...
Dyslipidemia is treated effectively with statins, but treatment has the potential to induce new-onset type-2 diabetes. Gut microbiota may contribute this outcome variability. We assessed associations of gut diversity and composition statins. Bacterial statin-associated diabetes (T2D) risk were also prospectively evaluated.
Abstract The Arctic is currently warming at an unprecedented rate, which may affect environmental constraints on the freshwater microbial communities found there. Yet, our knowledge of community structure and functional potential High microbes remains poor, even though they play key roles in nutrient cycling other ecosystem services. Here, using high‐throughput metagenomic sequencing genome assembly, we show that sediment Arctic's largest lake by volume, Lake Hazen, are phylogenetically...
Temperatures in the Arctic are expected to increase dramatically over next century, and transform high latitude watersheds. However, little is known about how microbial communities their underlying metabolic processes will be affected by these environmental changes freshwater sedimentary systems. To address this knowledge gap, we analyzed sediments from Lake Hazen, NU Canada. Here, exploit spatial heterogeneity created varying runoff regimes across watershed of uniquely large high-latitude...
Abstract Anthropogenic mercury remobilization has considerably increased since the Industrial Revolution in late 1700s. The Minamata Convention on Mercury is a United Nations treaty (2017) aiming at curbing emissions. Unfortunately, evaluating effectiveness of such global hampered by our inability to determine lag aquatic ecosystem responses change atmospheric deposition. Whereas past metal concentrations are obtained from core samples, there currently no means tracking historical...
ABSTRACT Gut microbiome sequencing has shown promise as a predictive biomarker for wide range of diseases, including classification liver disease and severity grading. However, the potential gut microbiota prospective risk prediction not been assessed. Here, we utilise shallow metagenomic data large population-based cohort (N=>7,115) ∼15 years electronic health register follow-up together with machine-learning to investigate capacity microbial predictors, individually in conjunction...
Previous studies on the association between metabolic biomarkers and hypertension have been limited by small sample sizes, low number of studied biomarkers, cross-sectional study design. In largest to date, we assess longitudinal associations high-abundance serum blood pressure (BP).We (N = 36 985; age 50.5 ± 14.2; 53.1% women) 4197; 49.4 11.8, 55.3% population samples Finnish individuals. We included 53 other detailed lipoprotein subclass measures in our analyses. BP using both conventional...
SUMMARY The spread of antibiotic-resistance genes in bacteria has severely reduced the efficacy antibiotics, now contributing to 1.3 million deaths annually. Despite far-reaching epidemiological implications this trend, extent which antimicrobial resistance load varies within human populations and drivers that contribute most variation remain unclear. Here, we demonstrate a representative cohort 7,095 Finnish adults 1 socio-demographic factors, lifestyle, gut microbial community composition...
Abstract Temperatures in the Arctic are expected to increase dramatically over next century, yet little is known about how microbial communities and their underlying metabolic processes will be affected by these environmental changes freshwater sedimentary systems. To address this knowledge gap, we analyzed sediments from Lake Hazen, NU Canada. Here, exploit spatial heterogeneity created varying runoff regimes across watershed of uniquely large lake at latitudes test a transition low high...
Abstract The Arctic is currently warming at an unprecedented rate, which may affect environmental constraints on the freshwater microbial communities found there. Yet, our knowledge of community structure and functional potential High microbes remains poor, even though they play key roles in nutrient cycling other ecosystem services. Here, using high-throughput metagenomic sequencing genome assembly, we show that sediment Arctic’s largest lake by volume, Lake Hazen, are phylogenetically...
Abstract Fatty liver disease is the most common in world. It characterized by a buildup of excess fat that can lead to cirrhosis and failure. The link between fatty gut microbiome has been known for at least 80 years. However, this association remains mostly unstudied general population because underdiagnosis small sample sizes. To address knowledge gap, we studied Liver Index (FLI), well-established proxy disease, composition representative, ethnically homogeneous Finland. We based our...
<b>OBJECTIVE:</b> To examine the previously unknown long-term association between gut microbiome composition and incident type 2 diabetes in a representative population cohort. <p><b>RESEARCH DESIGN AND METHODS:</b> We collected fecal samples of 5 572 Finns (mean age 48.7 years, 54.1% women) 2002 who were followed up for until Dec 31<sup>st</sup>, 2017. The sequenced using shotgun metagenomics. examined associations compositions...
Abstract OBJECTIVE To examine the previously unknown long-term association between gut microbiome composition and incident type 2 diabetes in a representative population cohort. RESEARCH DESIGN AND METHODS We collected fecal samples of 5 572 Finns (mean age 48.7 years, 54.1% women) 2002 who were followed up for until Dec 31 st , 2017. The sequenced using shotgun metagenomics. examined associations compositions multivariable-adjusted Cox regression models. first used Eastern Finland...