A5034887790- Health and Medical Studies
- Head and Neck Cancer Studies
- Heart Failure Treatment and Management
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- IL-33, ST2, and ILC Pathways
- GDF15 and Related Biomarkers
- Cerebrovascular and Carotid Artery Diseases
- Asthma and respiratory diseases
- Blood Pressure and Hypertension Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cervical Cancer and HPV Research
- Aortic Disease and Treatment Approaches
- Functional Brain Connectivity Studies
- Lymphoma Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Aortic aneurysm repair treatments
- Cardiac Imaging and Diagnostics
- Oral Health Pathology and Treatment
- Oral microbiology and periodontitis research
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Ischemic Stroke Management
- Health Promotion and Cardiovascular Prevention
- Advanced MRI Techniques and Applications
University Medical Center Hamburg-Eppendorf
2013-2022
Universität Hamburg
2012-2022
German Centre for Cardiovascular Research
2014-2021
Zimmer Biomet (Germany)
2020
Medizinisches Versorgungszentrum Prof. Mathey, Prof. Schofer
2020
Eppendorf (Germany)
2020
Klinik und Poliklinik für Neurologie
2018
Helmholtz Zentrum München
2017
Johannes Gutenberg University Mainz
2011
University Medical Center of the Johannes Gutenberg University Mainz
2011
The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and unique research platform network to obtain substantial knowledge about several important risk prognostic factors in major chronic diseases. A random sample of 45,000 participants between 45 74 years age from the general population Hamburg, Germany, are taking part an extensive baseline assessment at one dedicated center. Participants undergo 13 validated 5 novel examinations primarily...
The German National Cohort (NAKO) is an interdisciplinary health study aimed at elucidating causes for common chronic diseases and detecting their preclinical stages. This article provides overview of design, methods, participation in the examinations, quality assurance based on midterm baseline dataset (MBD) recruitment.More than 200,000 women men aged 20-69 years derived from random samples general population were recruited 18 centers (2014-2019). data collection comprised physical...
The use of β-receptor blockers in peripheral arterial disease is controversial for their impact on vasomotor tone. β-blocker nebivolol possesses vasodilating, endothelium-dependent, NO-releasing properties that might be beneficial disease. aim the study was to evaluate effects and tolerability comparison with metoprolol these patients. A total 128 patients intermittent claudication essential hypertension were included double-blind randomized receive 5 mg (N=65) or 95 (N=63) once daily. End...
Abstract Cerebral small vessel disease (CSVD) is a widespread condition associated to stroke, dementia and depression. To shed light on its opaque pathophysiology, we conducted neuroimaging study aiming assess the location of CSVD-induced damage in human brain network. Structural connectomes 930 subjects Hamburg City Health Study were reconstructed from diffusion weighted imaging. The connectome edges partitioned into groups according specific schemes: (1) connection grey matter regions, (2)...
Heart failure with preserved ejection fraction (HFpEF) is common in patients presenting dyspnoea. Recently, clinical tools were developed to facilitate the diagnosis of HFpEF. Here, we apply European Society Cardiology (ESC) 2016 heart guidelines and H2 FPEF HFA-PEFF scores a middle-aged sample general population compared different groups each other.This study included first 10 000 participants population-based Hamburg City Health Study. A total 5613 subjects, aged 62 ± 8.7 years (51.1%...
Cerebral small vessel disease (CSVD) is a common cause of morbidity and cognitive decline in the elderly population. However, characterizing pathophysiology its association with potential clinical sequelae early stages less well explored. We applied fixel-based analysis (FBA), novel framework investigating microstructural white matter integrity by diffusion-weighted imaging, to data 921 participants Hamburg City Health Study, comprising middle-aged individuals increased cerebrovascular risk...
<h3>Objectives</h3> We hypothesised that soluble ST2 (sST2) levels can identify people with elevated risk of subsequent cardiovascular disease (CVD) and add to existing prediction algorithms. <h3>Background</h3> is a receptor for the inflammatory cytokine IL33. Increased sST2 have been associated heart failure death in acute myocardial infarction patients general population. <h3>Methods</h3> measured high-sensitivity 8444 men women (25–74 years) from FINRISK97 prospective population cohort....
Low blood concentrations of the naturally occurring amino acid L-homoarginine (L-hArg) are related to impaired cardiovascular outcome and mortality in humans animals. L-hArg is a weak substrate nitric oxide synthase an inhibitor arginases vitro. The aim our study was obtain kinetic dynamic data after oral supplementation.In double-blind, randomized, placebo-controlled crossover study, 20 young volunteers received 125 mg once daily for 4 weeks. Kinetic parameters (Cmax , Tmax AUC0-24h ) were...
Hypertension represents a major cardiovascular risk factor. The pathophysiology of increased blood pressure (BP) is not yet completely understood. Transcriptome profiling offers possibilities to uncover genetics effects on BP. Based 2 populations including 2549 individuals, meta-analyses monocytic transcriptome-wide profiles were performed identify transcripts associated with Replication was in independent studies whole-blood transcriptome data 1990 individuals. For identified candidate...
Abstract Cerebral small vessel disease is a common finding in the elderly and associated with various clinical sequelae. Previous studies suggest disturbances integration capabilities of structural brain networks as mediating link between imaging presentations. To what extent cerebral might interfere other measures global network topology not well understood. Connectomes were reconstructed via diffusion weighted sample 930 participants from population based epidemiologic study. Linear models...
We examined the relationship between white matter hyperintensities (WMH) and cortical neurodegeneration in cerebral small vessel disease (CSVD) by investigating whether thickness is a remote effect of WMH through structural fiber tract connectivity population at increased risk CSVD. measured on T1-weighted images segmented FLAIR 930 participants population-based cohort study baseline. DWI-derived whole-brain probabilistic tractography was used to define regions. Linear mixed-effects models...
The lack of detectable precancerous lesions poses challenges to the early detection human papillomavirus-driven oropharyngeal cancer (HPV-OPC). Antibodies against HPV16 proteins, especially E6, are uniquely sensitive and specific biomarkers years prior HPV-OPC diagnosis. Thus, protein serology warrants clinical investigation for screening.Using multiplex serology, we analyzed serum antibodies first 5000 participants (n=4,424 sera, recruited 2016-2017) Hamburg City Health Study, a...
High blood pressure (BP) is associated with an increased rate of cardiovascular events and mortality. Cardiovascular biomarkers are able to predict long-term risk in the general population, particularly diseased cohorts. We undertook investigation effect 2 different antihypertensive treatments on a randomized trial.The TEAMSTA study included 481 hypertensive patients. They were either 80-mg telmisartan + 5-mg amlodipine (TA) or 40-mg olmesartan 12.5-mg hydrochlorothiazide (OH). The trial was...
The purpose of this work is to describe the objectives and design cardiovascular magnetic resonance (CMR) imaging in single center, prospective, population-based Hamburg City Health study (HCHS). HCHS aims at improving risk stratification for coronary artery disease (CAD), atrial fibrillation (AF) heart failure (HF). will finally include 45,000 inhabitants city (Germany) between 45 74 years who undergo an extensive evaluation collection biomaterials. Risk-scores CAD, AF HF are used create...
Previous studies demonstrated an association between severe chronic periodontitis (CP) and metabolic syndrome (MetS). However, these mostly used the outdated National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP) III case definition of MetS. Additionally, CP was rarely diagnosed based on a full-mouth examination. Thus, aim current study to re-evaluate potential MetS in Hamburg City Health Study (HCHS), large population-based survey middle-aged elderly men women Germany, view...
Abstract Aim of this study was to investigate the association between periodontitis and arterial hypertension, both which show correlations with classical cardiovascular risk factors inflammatory activity. Materials methods A cross-sectional analysis data from a large population-based health survey (the Hamburg City Health Study, HCHS) including 5934 participants complete periodontal examination blood pressure data, whom 5735 had medical records regarding anti-hypertensive medication,...
Data on self-reported cardiovascular and metabolic diseases are available for the first 100,000 participants of population-based German National Cohort (GNC, NAKO Gesundheitsstudie).To describe assessment methods frequency in Cohort.Using a computer-based, standardized personal interview, 101,806 (20-75 years, 46% men) from 18 nationwide study centres were asked to use predefined list report medical conditions ever diagnosed by physician, including or diseases. For latter, we calculated...
Infectious diseases continue to play an important role for disease perception, health-economic considerations and public health in Germany. In recent years, infectious have been linked the development of non-communicable diseases. Analyses German National Cohort (GNC) may provide deeper insights into this issue pave way new targeted approaches prevention.The aim was describe tools used assess present initial data on frequencies, as well relate GNC assessment collection methods other studies...
This population-based cross-sectional cohort study investigated the association of Mediterranean and DASH (Dietary Approach to Stop Hypertension) diet as well supplement intake with gray-scale median (GSM) presence carotid plaques comparing women men. Low GSM is associated plaque vulnerability. Ten thousand participants Hamburg City Health Study aged 45–74 underwent ultrasound examination. We analyzed in all plus those having (n = 2163). Dietary patterns were assessed via a food frequency...